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| 1 | Systematic review of ablative therapy for the treatment of renal allograft neoplasms显示文摘BACKGROUND To date,there are no guidelines on the treatment of solid neoplasms in the transplanted kidney.Historically,allograft nephrectomy has been considered the only reasonable option.More recently,nephron-sparing surgery (NSS) and ablative therapy (AT) have been proposed as alternative procedures in selected cases.AIM To review outcomes of AT for the treatment of renal allograft tumours.METHODS We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 Checklist.PubMed was searched in March 2019 without time restrictions for all papers reporting on radiofrequency ablation (RFA),cryoablation (CA),microwave ablation (MWA),high-intensity focused ultrasound (HIFU),and irreversible electroporation (IRE) of solid tumours of the kidney allograft.Only original manuscripts describing actual cases and edited in English were considered.All relevant articles were accessed in full text.Additional searches included all pertinent references.Selected studies were also assessed for methodological quality using a tool based on a modification of the Newcastle Ottawa scale.Data on recipient characteristics,transplant characteristics,disease characteristics,treatment protocols,and treatment outcomes were extracted and analysed.Given the nature and the quality of the studies available (mostly retrospective case reports and small retrospective uncontrolled case series),a descriptive summary was provided.RESULTS Twenty-eight relevant studies were selected describing a total of 100 AT procedures in 92 patients.Recipient age at diagnosis ranged from 21 to 71 years whereas time from transplant to diagnosis ranged from 0.1 to 312 mo.Most of the neoplasms were asymptomatic and diagnosed incidentally during imaging carried out for screening purposes or for other clinical reasons.Preferred diagnostic modality was Doppler-ultrasound scan followed by computed tomography scan,and magnetic resonance imaging.Main tumour types were: papillary renal cell carcinoma (RCC) and clear cell RCC.Maximal tumour diameter ranged from 5 to 55 mm.The vast majority of neoplasms were T1a N0 M0 with only 2 lesions staged T1b N0 M0.Neoplasms were managed by RFA (n = 78),CA (n = 15),MWA (n = 3),HIFU (n = 3),and IRE (n = 1).Overall,3 episodes of primary treatment failure were reported.A single case of recurrence was identified.Follow-up ranged from 1 to 81 mo.No cancer-related deaths were observed.Complication rate was extremely low (mostly < 10%).Graft function remained stable in the majority of recipients.Due to the limited sample size,no clear benefit of a single procedure over the other ones could be demonstrated.CONCLUSION AT for renal allograft neoplasms represents a promising alternative to radical nephrectomy and NSS in carefully selected patients.Properly designed clinical trials are needed to validate this therapeutic approach. | Evaldo Favi Nicholas Raison Federico Ambrogi Serena Delbue Maria Chiara Clementi Luca Lamperti Marta Perego Matteo Bischeri Mariano Ferraresso | 2019 | World Journal of Clinical Cases2019，7，17： | 2 |
| 2 | Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient显示文摘 | Sara Maria Viganò Alberto Edefonti Mariano Ferraresso Maria Luisa Ranzi Paolo Grossi Andrea Righini Roberto Rusconi Luigi Santambrogio Luciana Ghio | 2005 | Pediatric Nephrology2005，，8： | 1 |
| 3 | Influence of framework design on fracture strength of mandibular anterior all-ceramic resinbonded fixed partial dentures显示文摘 | Koutayas SO Kern M Ferraresso F | 2002 | Int J Prosthodont2002，15，3： | 1 |
| 4 | Comparison of pig,human and rat hepatocytes as a source of liver specific metabolic functions in culture systems-implications for use in bioartificial liver devices显示文摘 | Vilei MT Granato A Ferraresso C | 2001 | Int J Artif Organs2001，24，6： | 1 |
| 5 | Influence of the CYP3A5 genotype on tacrolimus pharmacokinetics and pharmacodynamics in young kidney transplant recipients 显示文摘 | Ferraresso M Tirelli A Ghio L | 2007 | Pediatr Transplant2007，11，3： | 1 |
| 6 | Comparision of pig,human and rat hepatocytes as a source of liver specific metabolic functions in culture systems implication for use in bioartificial liver divices显示文摘 | Vilei MT Granato A Ferraresso C | 2001 | J Artif Organs2001，24，： | 1 |
| 7 | Development and characterization of an overtraining animal model显示文摘 | HOHL R FERRARESSO R L DE OLIVEIRA R B | 2009 | Med Sci Sports Exe2009，41，5： | 1 |
| 8 | C2 is an age-independent parameter for optimal cyclosporine exposure in long-term kidney transplant recipients 显示文摘 | FERRARESSO M CITTERIO F GHIO L | 2004 | Transplant Proc2004，36，9： | 1 |
| 9 | Comparison of pig,human and rat hepatocytes as a source of liver specific metabolic functions in culture systems:implication for use in bioartificial liver devices显示文摘 | VILEI MT GRANATO A FERRARESSO C | 2001 | Int J Artif Organs2001，24，6： | 1 |
| 10 | Influence of framework design on fracture strength of mandibular anterior all-ceramic resin- bonded fixed partial dentures 显示文摘 | Koutayas S D Kern M Ferraresso F | 2002 | lnt J Prosthodont2002，15，3： | 1 |
| 11 | Conversion from cyclosporine to tacrolimus in pediatric kidney transplant recipients显示文摘 | Ferraresso M Ghio L Edefonti A | 2002 | Pediatr Nephrol2002，17，8： | 1 |
| 12 | Development and Characterization of an Overtraining Animal Model显示文摘 | RODRIGO HOHL RODRIGO LUíZ PERRONI FERRARESSO RENATO BUSCARIOLLI DE OLIVEIRA REJANE LUCCO RENé BRENZIKOFER DENISE VAZ DE MACEDO | 2009 | Medicine & Science in Sports & Exercise2009，，5： | 1 |
| 13 | Comparison of pig,human and rat hepatocytes as a source of liver specific metabolic functions in culture systems-implications for use in bioartificial liver devices 显示文摘 | Vilei MT Granato A Ferraresso C | 2001 | Int J Artif Organs2001，24，6： | 1 |
| 14 | The effect of CYP3A5 polymorphisms on the pharrnacokinetics of tacrolimus in adolescent kidney transplant recipients 显示文摘 | TIRELLI S FERRARESSO M GHIO L | 2008 | Med Sci Monit2008，14，5： | 1 |
| 15 | Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient 显示文摘 | Vigano S M Edefonti A Ferraresso M | 2005 | Pediatr Nephrol2005，20，8： | 1 |
| 16 | Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat显示文摘 | MURACA M FERRARESSO C VILEI M T | 2007 | Gut2007，56，12： | 1 |
| 17 | Frequencies and roles of CYP3AS, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation显示文摘 | Turolo S Tirelli A S Ferraresso M | 2010 | Pharmacol Rep2010，62，6： | 1 |
| 18 | Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat显示文摘 | Muraca M Ferraresso C Vilei MT | | Gut0，，： | 1 |
| 19 | Epigenetic silencing of TFPI-2 in canine diffuse large B-cell lymphoma显示文摘 | Ferraresso S Bresolin S AricòA | 2014 | PLo S One2014，9，92： | 1 |
| 20 | Intrasplenic transplantation of encapsulated cells, a novel approach to cell therapy显示文摘 | Aoki T Umehara Y Ferraresso C | 2002 | Cell Transplant2002，11，： | 1 |
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