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| 1 | Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy显示文摘Biliary lithiasis is an endemic condition in both Western and Eastern countries, in some studies affecting 20% of the general population. In up to 20% of cases, gallbladder stones are associated with common bile duct stones(CBDS), which are asymptomatic in up to one half of cases. Despite the wide variety of examinations and techniques available nowadays, two main open issues remain without a clear answer: how to cost-effectively diagnose CBDS and, when they are finally found, how to deal with them. CBDS diagnosis and management has radically changed over the last 30 years, following the dramatic diffusion of imaging, including endoscopic ultrasound(EUS) and magnetic resonance cholangiography(MRC), endoscopy and laparoscopy. Since accuracy, invasiveness, potential therapeutic use and costeffectiveness of imaging techniques used to identifyCBDS increase together in a parallel way, the concept of 'risk of carrying CBDS' has become pivotal to identifying the most appropriate management of a specific patient in order to avoid the risk of 'under-studying' by poor diagnostic work up or 'over-studying' by excessively invasive examinations. The risk of carrying CBDS is deduced by symptoms, liver/pancreas serology and ultrasound. 'Low risk' patients do not require further examination before laparoscopic cholecystectomy. Two main 'philosophical approaches' face each other for patients with an 'intermediate to high risk' of carrying CBDS: on one hand, the 'laparoscopy-first' approach, which mainly relies on intraoperative cholangiography for diagnosis and laparoscopic common bile duct exploration for treatment, and, on the other hand, the 'endoscopy-first' attitude, variously referring to MRC, EUS and/or endoscopic retrograde cholangiography for diagnosis and endoscopic sphincterotomy for management. Concerning CBDS diagnosis, intraoperative cholangiography, EUS and MRC are reported to have similar results. Regarding management, the recent literature seems to show better short and long term outcome of surgery in terms of retained stones and need for further procedures. Nevertheless, open surgery is invasive, whereas the laparoscopic common bile duct clearance is time consuming, technically demanding and involves dedicated instruments. Thus, although no consensus has been achieved and CBDS management seems more conditioned by the availability of instrumentation, personnel and skills than cost-effectiveness, endoscopic treatment is largely preferred worldwide. | Renato Costi Alessandro Gnocchi Francesco Di Mario Leopoldo Sarli | 2014 | World Journal of Gastroenterology2014，20，37： | 48 |
| 2 | Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation(Part Ⅱ:Treatment)显示文摘The second part of the Consensus Statement of the Italian Association of Hospital Gastroenterologists and Italian Society of Colo-Rectal Surgery reports on the treatment of chronic constipation and obstructed defecation.There is no evidence that increasing fluid intake and physical activity can relieve the symptoms of chronic constipation.Patients with normal-transit constipation should increase their fibre intake through their diet or with commercial fibre.Osmotic laxatives may be effective in patients who do not respond to fibre supplements.Stimulant laxatives should be reserved for patients who do not respond to osmotic laxatives.Controlled trials have shown that serotoninergic enterokinetic agents,such as prucalopride,and prosecretory agents,such as lubiprostone,are effective in the treatment of patients with chronic constipation.Surgery is sometimes necessary.Total colectomy with ileorectostomy may be considered in patients with slow-transit constipation and inertia coli who are resistant to medical therapy and who do not have defecatory disorders,generalised motility disorders or psychological disorders.Randomised controlled trials have established the efficacy of rehabilitative treatment in dys-synergic defecation.Many surgical procedures may be used to treat obstructed defecation in patients with acquired anatomical defects,but none is considered to be the gold standard.Surgery should be reserved for selected patients with an impaired quality of life.Obstructed defecation is often associated with pelvic organ prolapse.Surgery with the placement of prostheses is replacing fascial surgery in the treatment of pelvic organ prolapse,but the efficacy and safety of such procedures have not yet been established. | Antonio Bove Massimo Bellini Edda Battaglia Renato Bocchini Dario Gambaccini Vincenzo Bove Filippo Pucciani Donato Francesco Altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni | 2012 | World Journal of Gastroenterology2012，18，36： | 33 |
| 3 | Laparoscopic liver resection:Experience based guidelines显示文摘Laparoscopic liver resection(LLR) has been progressively developed along the past two decades. Despite initial skepticism, improved operative results made laparoscopic approach incorporated to surgical practice and operations increased in frequency and complexity. Evidence supporting LLR comes from case-series, comparative studies and meta-analysis. Despite lack of level 1 evidence, the body of literature is stronger and existing data confirms the safety, feasibility and benefits of laparoscopic approach when compared to open resection. Indications for LLR do not differ from those for open surgery. They include benign and malignant(both primary and metastatic) tumors and living donor liver harvesting. Currently, resection of lesions located on anterolateral segments and left lateral sectionectomy are performed systematically by laparoscopy in hepatobiliary specialized centers. Resection of lesions located on posterosuperior segments(1, 4a, 7, 8) and major liver resections were shown to be feasible but remain technically demanding procedures, which should be reserved to experienced surgeons. Hand-assisted and laparoscopy-assisted procedures appeared to increase the indications of minimally invasive liver surgery and are useful strategies applied to difficult and major resections. LLR proved to be safe for malignant lesions and offers some short-term advantages over open resection. Oncological results including resection margin status and long-term survival were not inferior to open resection. At present, surgical community expects high quality studies to base the already perceived better outcomes achieved by laparoscopy in major centers' practice. Continuous surgical training, as well as new technologies should augment the application of lap-aroscopic liver surgery. Future applicability of new technologies such as robot assistance and image-guided surgery is still under investigation. | fabricio ferreira coelho jaime arthur pirola kruger gilton marques fonseca raphael leonardo cunha araújo vagner birk jeismann marcos vinícius perini renato micelli lupinacci ivan cecconello paulo herman | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 22 |
| 4 | 食道的有鳞的房间癌 - 先锋损害和早诊断显示文摘 Squamous cell carcinoma of the esophagus (SCCE) carries a poor prognosis due to late diagnosis.Early detection is highly desirable,since surgical and endoscopic resection offers the only possible cure for esophageal cancer.Population screening should be undertaken in high risk areas,and in low or moderate risk areas for people with risk factors (alcoholics,smokers,mate drinkers,history of head and neck cancer,achalasia and lye stricture of the esophagus).Esophageal balloon cytology is an easy and inexpensive sampling technique,but the current methods are insufficient for primary screening due to sampling errors.Conventional endoscopy with biopsy remains the standard procedure for the identification of pre-malignant and early malignant changes in esophageal mucosa and endoscopic detection.It may be enhanced by several techniques such as dye and optic chromoendoscopy,magnifying endoscopy,and optical-based spectroscopic and imaging modalities.Since more than 80% of SCCE deaths occur in developing countries,where expensive techniques such as narrow band imaging (NBI) and autofluorescence imaging are unavailable,the most cost-effective tool for targeting biopsies may be Lugol dye chromoendoscopy,since it is easy,accurate,inexpensive and available worldwide.In ideal conditions,or in developed countries,is it reasonable to think that optimal detection will require a combination of techniques,such as the combination of Lugol’s chromoendoscopy and NBI to identify esophageal areas that require further characterization by a high resolution technique.The efficacy and cost-effectiveness will determine whether these modalities will become part of standard endoscopy practice. | Antonio Barros Lopes Renato Borges Fagundes | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 20 |
| 5 | Consensus statement AIGO/SICCR:Diagnosis and treatment of chronic constipation and obstructed defecation(partⅠ:Diagnosis)显示文摘Chronic constipation is a common and extremely troublesome disorder that significantly reduces the quality of life,and this fact is consistent with the high rate at which health care is sought for this condition.The aim of this project was to develop a consensus for the diagnosis and treatment of chronic constipation and obstructed defecation.The commission presents its results in a 'Question-Answer' format,including a set of graded recommendations based on a systematic review of the literature and evidence-based medicine.This section represents the consensus for the diagnosis.The history includes information relating to the onset and duration of symptoms and may reveal secondary causes of constipation.The presence of alarm symptoms and risk factors requires investigation.The physical examination should assess the presence of lesions in the anal and perianal region.The evidence does not support the routine use of blood testing and colonoscopy or barium enema for constipation.Various scoring systems are available to quantify the severity of constipation;the Constipation Severity Instrument for constipation and the obstructed defecation syndrome score for obstructed defecation are the most reliable.The Constipation-Related Quality of Life is an excellent tool for evaluating the patient's quality of life.No single test provides a pathophysiological basis for constipation.Colonic transit and anorectal manometry define the pathophysiologic subtypes.Balloon expulsion is a simple screening test for defecatory disorders,but it does not define the mechanisms.Defecography detects structural abnormalities and assesses functional parameters.Magnetic resonance imaging and/or pelvic floor sonography can further complement defecography by providing information on the movement of the pelvic floor and the organs that it supports.All these investigations are indicated to differentiate between slow transit constipation and obstructed defecation because the treatments differ between these conditions. | Antonio Bove Filippo Pucciani Massimo Bellini Edda Battaglia Renato Bocchini Donato Francesco Altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni Dario Gambaccini Vincenzo Bove | 2012 | World Journal of Gastroenterology2012，18，14： | 20 |
| 6 | 几株解纤维素生防芽孢杆菌的分子鉴定及其抗逆促生特性分析显示文摘【目的】探究青藏高原解纤维素生防芽孢杆菌资源。【方法】采用BOX-PCR指纹图谱分析、gyr B基因及16S r RNA基因序列分析,对分离自青海互助北山桦树根围的5株芽孢杆菌进行分子鉴定;通过CMC法检测菌株降解纤维素活性;平板对峙法检测菌株拮抗病原真菌及病原细菌活性;检测菌株的耐盐性、低温适生性;测定菌株促种子萌发及幼苗生长特性。【结果】5株菌均鉴定为解淀粉芽孢杆菌Bacillus amyloliquefaciens;具有显著降解纤维素的特性,在CMC平板上形成纤维素降解透明圈直径≥20 mm;对油菜菌核病菌(Sclerotinia sclerotiorum)、瓜类枯萎病菌(Fusarium oxysporum)、水稻白叶枯病菌(Xanthomonas oryzae pv.oryzae)及植物梨火疫病菌(Erwinia amylovora)均有显著拮抗活性;菌株可在含Na Cl浓度为11%的LB平板上正常生长,在10°C低温条件下生长良好;菌株BS11、BS12菌悬液(细胞浓度106 CFU/m L)可促进水稻种子萌发及幼苗生长。【结论】5株B.amyloliquefaciens菌株为抗逆性强的、具有降解纤维素活性的生防芽孢杆菌,在青藏高原生态农业及畜牧产业中具有应用潜力。 | 谢永丽 Renato D’Ovidio Stefania Masci 范晶 李云龙 | 2017 | 微生物学通报2017，44，2： | 18 |
| 7 | Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention显示文摘Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic growth.Several environmental risk factors,mainly changes in diet and life style,have been suggested to underlie the rise of CRC in these populations.Diet and lifestyle impinge on nuclear receptors,on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis.In this respect,the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations.The data from these studies may have important implications for the global prevention and treatment of CRC. | Faraz Bishehsari Mahboobeh Mahdavinia Michele Vacca Reza Malekzadeh Renato Mariani-Costantini | 2014 | World Journal of Gastroenterology2014，20，20： | 18 |
| 8 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 9 | HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays显示文摘AIM:To compare the performance of three commercially available anti-human epidermalgrowth factor receptor 2(HER2)antibodies in whole-tissue sections and tissue microarrays(TMAs)of a series of gastric tumors.METHODS:We present a comparative analysis of three anti-HER2 antibodies(HercepTest,4B5 and SP3)using TMA and whole-tissue sections prepared from the same paraffin blocks of 199 gastric adenocarcinomas operated upon between January 2004 and December2008 at a Brazilian cancer hospital.The data on the patients’age,sex,the anatomical location of the tumor and the Lauren’s histological classification were collected from clinical and pathological records.The immunohistochemical(IHC)results were examined by two pathologists and the cases were classified as positive(3+),equivocal(2+)and negative(0 or 1+),according to the criteria of the IHC scoring system of gastric cancer.TMAs and whole-tissue sections were evaluated separately and independently.All cases yielding discordant IHC results and/or scored as 2+were subjected to dual-color in situ hybridization in order to determine the final HER2 status.Besides determining the sensitivity and predictive value for HER2-positive status,we measured the accuracy of each antibody by calculating the area under the receiver operating characteristic(ROC)curve.The agreement between the results obtained using the TMAs and those obtained using the whole-tissue sections was assessed by means of Kappa coefficient.RESULTS:Intratumoral heterogeneity of HER2 expression was observed with all antibodies.HER2-positive expression(3+)in the whole-tissue sections was observed in 23 cases(11.6%)using the 4B5 antibody,in 18 cases(9.1%)using the SP3 antibody and in 10 cases(5.1%)using the HercepTest antibody.In the TMAs,11 positive cases(5.6%)were identified using SP3 antibody,9(4.6%)using the 4B5 antibody and 6(3%)using the HercepTest antibody.The sensitivity using whole-tissue sections and TMA,respectively,was 95.2%and 42.9%with 4B5,90.5%and 66.7%with SP3 and 47.6%and42.9%with HercepTest.The accuracy,calculated from the area under the ROC curve,using whole-tissue sections and TMA,respectively,was 0.91 and 0.79 by 4B5,0.86 and 0.80 by SP3 and 0.73 and 0.71 by HercepTest.The concordance of the results obtained using wholetissue sections and TMA was 97.4%(Kappa 0.75)using HercepTest,85.6%(Kappa 0.56)using SP3 and 84.1%(Kappa 0.38)using 4B5.CONCLUSION:The use of the 4B5 antibody on wholetissue sections was the most accurate IHC method for evaluating HER2 expression in gastric adenocarcinoma. | Lucas Faria Abraho-Machado Alexandre Andrade dos Anjos Jácome Durval Renato Wohnrath José Sebastio dos Santos Estela Cristina Carneseca José Humberto Tavares Guerreiro Fregnani Cristovam Scapulatempo-Neto | 2013 | World Journal of Gastroenterology2013，19，38： | 12 |
| 10 | Targeting of Pollen Tubes to Ovules Is Dependent on Nitric Oxide (NO) Signaling显示文摘指导在雌蕊内表明那次驱动器花粉试管航行,在很大程度上,珠孔指向仍然是未知的。在 vitro 的以前的研究显示出那氮的氧化物(没有) 在百合(Lilium longiflorum ) 为花粉试管生长作为否定向化性的暗示工作。而且, Arabidopsis thaliana Atnos1 变异的工厂,给有缺陷者看没有生产,减少了富饶。这里,我们集中在角色不在 pollenpistil 通讯的过程,用 Arabidopsis in-vivo 和百合 semi-vivo 试金。在之间跨授粉野类型并且 Atnos1 种变化影响的表演以与反常花粉试管指导兼容的一个方法的雌蕊纸巾。而且,染色为的 DAF-2DA 不,在 kanadi,花的异种显示出存在不在在珠孔附近的一个不对称的限制区域。pollenpistil 相互作用 transcriptome 显示 AtNOS1 和二硝酸盐 Reductases (nr1 和 nr2 ) 的抄本的 time-course-specific 调整,它一起被认为触发一条通常认为的没有发信号小径。有孤立的小卵和百合花粉的 Semi-vivo 试金进一步证明那不为珠孔指向发生是必要的。这条证据被 CPTIO 处理在面对小卵的花粉试管与汽球尖端的随后的形成支持。在花粉试管的钙流入的激活部分救了正常花粉试管形态学,建议这条小径也依赖于 Ca2+ 发信号。一个角色不在 modulating Ca2+ 发信号被直接成像进一步证实 cytosolic 免费 Ca2+ 集中在不导致的重取向期间 Ca2+ occurone 的二座山峰在减速 / 站反应期间,第二在重取向和生长恢复期间。一起拿,这些结果在 pollenpistil 期间为没有发信号的事件的参予提供证据相互作用。特殊关联,不似乎直接影响由 modulating 指向花粉试管到小卵的珠孔它的可散开的因素的行动。 | Ana Margarida Prado Renato Colaco Nuno Moreno Ana Catarina Silva Jose A. Feijo | 2008 | Molecular Plant2008，1，4： | 12 |
| 11 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 12 | Hepatocellular carcinoma: Where are we?显示文摘Hepatocellular carcinoma(HCC) is the second cause of death due to malignancy in the world, following lung cancer. The geographic distribution of this disease accompanies its principal risk factors: Chronic hepatitis B virus and hepatitis C virus infection, alcoholism, aflatoxin B1 intoxication, liver cirrhosis, and some genetic attributes. Recently, type Ⅱ diabetes has been shown to be a risk factor for HCC together with obesity and metabolic syndrome. Although the risk factors are quite well known and it is possible to diagnose HCC when the tumor is less than 1 cm diameter, it remains elusive at the beginning and treatment is often unsuccessful. Liver transplantation is thus far considered the best treatment for HCC as it cures HCC and the underlying liver disease. Using the Milan criteria, overall survival after liver transplantation for HCC is about 70% after 5 years. Many attempts have been made to go beyond the Milan Criteria and according to recent works reasonably good results have been achieved by using a histochemical marker such as cytokeratine 19 and the so-called 'up to seven criteria' to divide patients into categories according to their risk of relapse. In addition to liver transplantation other therapies have been proposed such as resection, tumor ablation by different means, embolization and chemotherapy. An important step in the treatment of advanced HCC has been the introduction of sorafenib, the first oral, systemic drug that has provided significant improvement in survival. Treatment of HCC patients must be multidisciplinary and by using the different approaches discussed in this review it is possible to offer prolonged survival and quite good and sometimes even excellent quality of life to many patients. | Roberto Mazzanti Umberto Arena Renato Tassi | 2016 | World Journal of Experimental Medicine2016，6，1： | 10 |
| 13 | A Hybrid Immigrants Scheme for Genetic Algorithms in Dynamic Environments显示文摘动态优化问题是随着时间的过去包含变化的一种优化问题。自从球门不再是寻找一个固定问题的最佳的答案,但是随着时间的过去追踪动人的最佳,他们提出严肃的挑战到传统的优化方法以及常规基因算法。动态优化问题在最近的年里从基因算法社区吸引了成长兴趣。几条途径被开发了在动态环境提高基因算法的表演。一条途径是经由随机的移民维持人口的差异。这篇论文建议联合精英统治,两重性和随机的移民的概念让基因算法处理动态优化问题的一个混合移民计划。在这个混合计划,最好的个人,即,精英,作为底从以前的产生和它的双个人被检索经由传统的变化计划创造移民。和一些随机的移民的这些基于精英统治、基于两重性的移民被代替进当前的人口,代替在人口的最糟的个人。这些三种移民试图分别地探讨细微、中等、重要的度的环境变化并且高效地因此使基因算法适应服从于变化的不同严厉的动态环境。基于一系列系统地构造的动态测试问题,实验被执行与混合移民计划和传统的随机的移民计划调查基因算法的表演。试验性的结果为在动态环境改进基因算法的表演验证建议混合移民计划的效率。关键词基因算法 - 随机的移民 - 基于精英统治的移民 - 两重性 - 动态优化问题这个工作被英国 EPSRC 支持(没有。EP/E060722/01 ) 并且巴西 FAPESP (Proc。04/04289-6 ) 。杨胜祥收到了 B.Sc。并且 M.Sc。在自动控制的学位和在从东北大学设计的系统的博士学位, P. R。在 1993, 1996 和 1999 的中国分别地。他是在计算机科学系的一个博士后的研究伙伴,从 1999 年 10 月的国王鈥檚 学院伦敦到 2000 年 10 月。他当前是在在累斯特的大学的计算机科学系的一个讲师,英国。他在书,杂志和会议出版了超过 50 篇论文。他有 co-guest-edited 为基因编程和可发展的机器的杂志的一期特刊并且共同编辑一本书在动态、不明确的环境的进化计算,在 2007 年 3 月出版了。他的当前的研究兴趣包括进化、基因的算法,为组合优化问题的人工的神经网络,安排问题,动态优化问题,和网络流动问题和算法。杨博士担任区域编辑,伙伴编辑和三本国际杂志的编委的成员。他是在动态、不明确的环境的进化计算上的工作组的一个成员,进化计算技术委员会, IEEE 计算智力社会(CIS ) 。他是 IEEE 和 ACM SIGEVO 的一个成员。Renato 听贸 s 收到了 B.Sc。在从 S 的州立大学的电力工程的度 ? o Paulo (UNESP ) ,在 1994 的巴西,和 M.Sc。并且在来自 S 的大学的电力工程的博士学位 ? 在 S 的 o Paulo (USP )? o 卡洛斯,在 1999 和 2003 的巴西分别地。他然后在 S 加入了 USP 的计算机科学系 ? o 卡洛斯作为一个研究科学家。他当前是在物理的系和在 Ribeir 的 USP 的数学的一个助教 ? o Preto。他的研究兴趣包括进化算法,动态优化,机器人学,容错,和神经网络。 | Shengxiang Yang Renato Tinós | 2007 | International Journal of Automation and computing2007，4，3： | 9 |
| 14 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 15 | Immune checkpoint inhibitors in cancer therapy显示文摘In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4(CTLA-4) and programmed cell death protein 1(PD-1) which have been shown to have potent immunomodulatory effects through their function as negative regulators of T cell activation. CTLA-4, through engagement with its ligands B7-1(CD80) and B7-2(CD86), plays a pivotal role in attenuating the activation of naive and memory T cells. In contrast, PD-1 is primarily involved in modulating T cell activity in peripheral tissues via its interaction with PD-L1 and PD-L2. The discovery of these negative regulators of the immune response was crucial in the development of checkpoint inhibitors. This shifted the focus from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses. | Eika S.Webb Peng Liu Renato Baleeiro Nicholas R.Lemoine Ming Yuan Yaohe Wang | 2018 | The Journal of Biomedical Research2018，32，5： | 8 |
| 16 | 有关正畸初始弓丝就位后的疼痛感——热激活弓丝和超弹弓丝的随机对照研究显示文摘目的:正畸热激活弓丝能够产生比超弹弓丝更轻、更符合生物学的力量.从而能够降低正畸初次就诊所产生的疼痛感。然而.该说法的证据却较少。本研究的目的即比较使用热激活弓丝(HANT)和超弹弓丝(SE)作为正畸初始弓丝就位后患者的疼痛感的差别。方法和材料:共纳入30例患者(男11例,女19例,年龄11~26岁)。上颌或下颌粘接金属托槽.随机使用0.016英寸热激活弓丝和0016英寸超弹弓丝,橡皮圈结扎入槽。要求患者使用视觉模拟量表(VAS)记录7d内不同时刻(8:00.12:00.16:00,2000.2400)的疼痛指数。结果:两组结果均显示疼痛程度最重的为第2天,疼痛程度最轻的为第7天:热激活弓丝组第2.3,4天的VAS评分均显著低于超弹弓丝组(P〈0.005)。针对服用止痛药、体育锻炼、合并其他来源的疼痛和伴随压力性事件等情况做出调整后.结果仍然相同。超弹弓丝组在第3天服用止痛药的频率明显高于热激活组(P〈0.05)。不同时间点间疼痛感未发现明显差异,牙列拥挤与疼痛程度未发现相关性.上下颔的疼痛感也无明显差异。结论:使用热激活弓丝能够降低正畸初诊疼痛感。 | Iacopo Cioffi Antonclla Piccolo Renato Tagliaferri Sergio Paduano Angela Galeotti Roberto Martina 邓金荣 高雪梅 | 2012 | 中国口腔医学继续教育杂志2012，15，6： | 8 |
| 17 | Enamel microabrasion: An overview of clinical and scientific considerations显示文摘Superficial stains and irregularities of the enamelare generally what prompt patients to seek dental intervention to improve their smile. These stains or defects may be due to hypoplasia, amelogenesis imperfecta, mineralized white spots, or fluorosis, for which enamel microabrasion is primarily indicated. Enamel microabrasion involves the use of acidic and abrasive agents, such as with 37% phosphoric acid and pumice or 6% hydrochloric acid and silica, applied to the altered enamel surface with mechanical pressure from a rubber cup coupled to a rotatory mandrel of a lowrotation micromotor. If necessary, this treatment can be safely combined with bleaching for better esthetic results. Recent studies show that microabrasion is a conservative treatment when the enamel wear is minimal and clinically imperceptible. The most important factor contributing to the success of enamel microabrasion is the depth of the defect, as deeper, opaque stains, such as those resulting from hypoplasia, cannot be resolved with microabrasion, and require a restorative approach. Surface enamel alterations that result from microabrasion, such as roughness and microhardness, are easily restored by saliva. Clinical studies support the efficacy and longevity of this safe and minimally invasive treatment. The present article presents the clinical and scientific aspects concerning the microabrasion technique, and discusses the indications for and effects of the treatment, including recent works describing microscopic and clinical evaluations. | Núbia Inocencya Pavesi Pini Daniel Sundfeld-Neto Flavio Henrique Baggio Aguiar Renato Herman Sundfeld Luis Roberto Marcondes Martins José Roberto Lovadino Débora Alves Nunes Leite Lima | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 18 | palliative care and end-stage colorectal cancer management:The surgeon meets the oncologist显示文摘Colorectal cancer(CRC)is a common neoplasia in the Western countries,with considerable morbidity and mortality.Every fifth patient with CRC presents with metastatic disease,which is not curable with radical intent in roughly 80%of cases.Traditionally approached surgically,by resection of the primitive tumor or stoma,the management to incurable stageⅣCRC patients has significantly changed over the last three decades and is nowadays multidisciplinary,with a pivotal role played by chemotherapy(CHT).This latter have allowed for a dramatic increase in survival,whereas the role of colonic and liver surgery is nowadays matter of debate.Although any generalization is difficult,two main situations are considered,asymptomatic(or minimally symptomatic)and severely symptomatic patients needing aggressive management,including emergency cases.In asymptomatic patients,new CHT regimens allow today long survival in selected patients,also exceeding two years.The role of colonic resection in this group has been challenged in recent years,as it is not clear whether the resection of primary CRC may imply a further increase in survival,thus justifying surgeryrelated morbidity/mortality in such a class of shortliving patients.Secondary surgery of liver metastasis is gaining acceptance since,under new generation CHT regimens,an increasing amount of patients with distant metastasis initially considered non resectable become resectable,with a significant increase in long term survival.The management of CRC emergency patients still represents a major issue in Western countries,and is associated to high morbidity/mortality.Obstruction is traditionally approached surgically by colonic resection,stoma or internal by-pass,although nowadays CRC stenting is a feasible option.Nevertheless,CRC stent has peculiar contraindications and complications,and its long-term cost-effectiveness is questionable,especially in the light of recently increased survival.Perforation is associated with the highest mortality and remains mostly matter for surgeons,by abdominal lavage/drainage,colonic resection and/or stoma.Bleeding and other CRC-related symptoms(pain,tenesmus,etc.)may be managed by several mini-invasive approaches,including radiotherapy,laser therapy and other transanal procedures. | Renato Costi Francesco Leonardi Daniele Zanoni Vincenzo Violi Luigi Roncoroni | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 19 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 20 | Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review显示文摘Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk patients.Pre-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse events.Several studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage time.This review was designed to provide an update on the current scientific evidence regarding PEP available in the literature. | Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo Lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
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