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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Serotonin and gastrin ceils in rat gastrointestinal tract after thyroarathyroidectomy and induced hyperthyroidism 显示文摘 | Portela-Gomes GM Albuquerque JP Ferra MA | 2000 | Diq Dis Sci2000，45，4： | 1 |
| 4 | Sevoflurane in airway management using fibrobronchoscopy:apropos of 2 difficult orotracheal intubation cases显示文摘 | FERRA M VILA P ESCUDERO A | 1999 | Rev Esp Anestesiol Reanim1999，46，6： | 1 |
| 5 | The role of VEGF in normal and neoplastic hematopoiesis显示文摘 | Gerber HP Ferra ra N | 2003 | J Mol Med2003，81，1： | 1 |
| 6 | Molecular and biological properties of the vascular endothelial growth factor family of proteins显示文摘 | Ferra N Houck K Jakeman L | 1992 | Endocr Rev1992，13，1： | 1 |
| 7 | Study of influence of synthesis con- ditions on properties of melamine-urea formaldehyde resins显示文摘 | Paiva N T Pereira J Ferra J M | 2012 | In- ternational Wood Products Journal2012，3，1： | 1 |
| 8 | Crystallization of Na2O-MgO-CaO-Al2O3-SiO2 Glassy Systems Formulated from Wasted Products显示文摘 | Luisa Barbieri Anna Maria Ferra | 2000 | Journal of the AmericanCeramic Society2000，83，10： | 1 |
| 9 | Alternative splicing account for the four forms of myelin basic protein显示文摘 | Ferra F Engh H Hudson L | 1985 | Cell1985，43，3： | 1 |
| 10 | Salvage treatment with infliximab of steroid-resistant graft-versus-host disease in allogeneic transplanted patients 显示文摘 | Motllo C Ferra C Lopez L | 2011 | Med Clin (Barc)2011，137，3： | 1 |
| 11 | Serum gastrin and gastrin - inmmnoreactive cells in the antral mucosa of patients with alcoholic liver disease显示文摘 | Cortez- Pinto H Ferra MA Baptista A etal | 2000 | APMIS2000，108，1： | 1 |
| 12 | Adaptive changes of the enteroch - romaffin and gastrin cells in the rat gastrointestinal tract following subtotal colectomy显示文摘 | Albuquerque JF Ferra MA Portela - Gomes GM | 2006 | Scand J Gastroenterol2006，41，8： | 1 |
| 13 | Mechanical study of PLA-PCL fibers during in vitro degradation 显示文摘 | Vieira AC Vieira JC Ferra JM | 2011 | J Mech Behav Biomed Mater2011，4，3： | 1 |
| 14 | Modeling of vi- bration damping in composite structures 显示文摘 | Ahmed Maher Fawkia Ramad-m Mohmed Ferra | 1999 | Composite Struc- tures1999，，46： | 1 |
| 15 | Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies显示文摘 | Gerber HP Ferra N | 2005 | Cancer Res2005，65，3： | 1 |
| 16 | Pentoxifylline, ciprofloxacin and predisone failed to prevention transplant related toxicities in bone marrow transplantation recipients and were associated with an increased incidence of infection complication 显示文摘 | FERRA C SANJOSE S LASTRA C F | 1997 | Bone Marrow Transplant1997，20，： | 1 |
| 17 | Prepara- tive transformation of natural phospholipids catalysed by phospholipase D from Streptomyces 显示文摘 | ARRIGO P D FERRA L PIERGIANNI V | 1996 | J Chem Soc Per- kin Trans1996，，21： | 1 |
| 18 | Immunotherapy in bladder cancer with keyholelimpet hemocyanin: a randomized study显示文摘 | Jurinic CD Ferra N Fuggles H | 1988 | J Urol1988，139，： | 1 |
| 19 | Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHF ) gene fn patients with homocystinuria显示文摘 | Sibani S Ohristensen B O'Ferra]l E | 2012 | um Murat2012，15，： | 1 |
| 20 | Application of Multilinear Regression Analysis to the Evaluation of Standard pH Values for Potassium Hydrogen Phthalate Reference Value Standard Solutions at Temperatures up to 498K显示文摘 | Covington A K Ferra M I A Zou Z Y | 1985 | Electrochim Acta1985，30，6： | 1 |
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