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| 1 | Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration显示文摘Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses.Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials.However,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory.Currently,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling pathways.Properties of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal system.Based on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune reprogramming.Here,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune environment.Such strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application. | Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai Yulei Huang Xiaodan Chen Lijia Huang Jiali Tan | 2020 | Regenerative Biomaterials2020，7，3： | 22 |
| 2 | Prussian blue nanoparticle-loaded microbubbles for photothermally enhanced gene delivery through ultrasound-targeted microbubble destruction显示文摘By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy. | Xiaoda Li Xiuli Yue Jinrui Wang Xiaolong Liang Lijia Jing Li Lin Yongbo Yang Shanshan Feng Yajun Qian Zhifei Dai | 2016 | Science Bulletin2016，61，2： | 4 |
| 3 | Low-cycle fatigue behavior of permanent mold cast and die-cast Al-Si-Cu-Mg alloys显示文摘Fatigue failure is one of the main failure forms of Al-Si-Cu-Mg aluminum alloys.To feature their mechanical aspect of fatigue behavior,the low-cycle fatigue behavior of permanent mold cast and die-cast Al-Si-Cu-Mg alloys at room temperature was investigated.The experimental results show that both permanent mold cast and die-cast Al-Si-Cu-Mg alloys mainly exhibit cyclic strain hardening.At the same total strain amplitude,the die-cast Al-Si-Cu-Mg alloy shows higher cyclic deformation resistance and longer fatigue life than does the permanent mold cast Al-Si-Cu-Mg alloy.The relationship between both elastic and plastic strain amplitudes with reversals to failure shows a monotonic linear behavior,and can be described by the Basquin and Coffin-Manson equations,respectively. | Chen Lijia Wang Di Che Xin Li Feng | 2012 | China Foundry2012，9，1： | 2 |
| 4 | Osteoinduction of hydroxyapatite/β-tricalcium phosphate bioceramics in mice with a fractured fibula显示文摘 | Lijia Cheng Feng Ye Ruina Yang | 2010 | Acta Biomaterialia2010，6，： | 1 |
| 5 | Intensity image denoising for laser active imaging system u- sing nonsubsampled contourlet transform and SURE ap- proach 显示文摘 | Xiao feng Li Jun Xu Jijun Luo Lijia Cao Shengxiu Zhang | 2012 | Optik-International Journal for Light and Elec- tron Optics2012，9，123： | 1 |
| 6 | Colorless WDM-PON Using Single Side Band Carrier Suppressed Signals Mitigating Carrier Rayleigh Backscattering显示文摘A new scheme is offered for minimizing carrier Rayleigh backscattering(CRB) in single feeder fiber based wavelength division multiplexed passive optical network(WDM-PON). The proposed scheme is based on single side band carrier suppressed(SSBCS) signal, both at network and receiver sides, used for the first time at optical line terminal(OLT) and optical network unit(ONU) sides. We use dual-drive Mach-zehnder modulator(DD-MZM) for generating SSB-CS signals, which decreases the expense per bit in full transmission. SSB-CS mitigates CRB, both at OLT and ONU sides, because of having no chance of reflections from the carrier. Since no extra dedicated RF or laser source is used at ONU side, we thus achieve cost effective colorless WDM-PON system. Suppressed signals from four channels, each of 10 Gbps, are multiplexed before injecting into the fiber span of 25 km at OLT. At ONU side, half of the downlink power is used for re-modulating the data signal. The simulation results show an errorfree transmission. Moreover, the detailed power budget calculations show that the proposed scheme can be sought out for splitting ratio up to 128. Hence it offers enough system's margin for unseen losses. | Rahat Ullah Bo Liu Qi Zhang Yousaf Khan Amjad Ali Qinghua Tian Feng Tian M.Saad Khan Tabinda Salam Sibghat Ullah Lijia Zhang Xiangjun Xin | 2016 | China Communications2016，13，12： | 0 |
| 7 | Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration显示文摘The seek of bioactive materials for promoting bone regeneration is a challenging and longterm task.Functionalization with inorganic metal ions or drug molecules is considered effective strategies to improve the bioactivity of various existing biomaterials.Herein,amorphous calcium magnesium phosphate(ACMP)nanoparticles and simvastatin(SIM)-loaded ACMP(ACMP/SIM)nanocomposites were developed via a simple co-precipitation strategy.The physiochemical property of ACMP/SIM was explored using transmission electron microscope(TEM),Fourier transform infrared spectroscopy(FTIR),powder X-ray diffraction(XRD)and highperformance liquid chromatograph(HPLC),and the role of Mg^(2+) in the formation of ACMP/SIM was revealed using X-ray absorption near-edge structure(XANES).After that,the transformation process of ACMP/SIM in simulated body fluid(SBF)was also tracked to simulate and explore the in vivo mineralization performance of materials.We find that ACMP/SIM releases ions of Ca^(2+),Mg^(2+)and PO_(4)^(3),when it is immersed in SBF at 37℃,and a phase transformation occurred during which the initially amorphous ACMP turns into self-assembled hydroxyapatite(HAP).Furthermore,ACMP/SIM displays high cytocompatibility and promotes the proliferation and osteogenic differentiation of MC3T3-E1 cells.For the in vivo studies,lamellar ACMP/SIM/Collagen scaffolds with aligned pore structures were prepared and used to repair a rat defect model in calvaria.ACMP/SIM/Collagen scaffolds show a positive effect in promoting the regeneration of calvaria defect after 12weeks.The bioactive ACMP/SIM nanocomposites are promising as bone repair materials.Considering the facile preparation process and superior in vitro/vivo bioactivity,the as-prepared ACMP/SIM would be a potential candidate for bone related biomedical applications. | Yingying Jiang Shuo Tan Jianping Hu Xin Chen Feng Chen Qianting Yao Zhi Zhou Xiansong Wang Zifei Zhou Yunshan Fan Junjian Liu Yize Lin Lijia Liu Shisheng He | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 8 | NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos显示文摘Zygotic genome activation(ZGA)marks the beginning of the embryonic program for a totipotent embryo,which gives rise to the inner cell mass(ICM)where pluripotent epiblast arises,and extraembryonic trophectoderm.However,how ZGA is connected to the first lineage segregation in mammalian embryos remains elusive.Here,we investigated the role of nuclear receptor(NR)transcription factors(TFs),whose motifs are highly enriched and accessible from the 2-cell(2C)to 8-cell(8C)stages in mouse embryos.We found that NR5A2,an NR TF strongly induced upon ZGA,was required for this connection.Upon Nr5a2 knockdown or knockout,embryos developed beyond 2C normally with the zygotic genome largely activated.However,4–8C-specific gene activation was substantially impaired and Nr5a2-deficient embryos subsequently arrested at the morula stage.Genome-wide chromatin binding analysis showed that NR5A2-bound cis-regulatory elements in both 2C and 8C embryos are strongly enriched for B1 elements where its binding motif is embedded.NR5A2 was not required for the global opening of its binding sites in 2C embryos but was essential to the opening of its 8C-specific binding sites.These 8C-specific,but not 2C-specific,binding sites are enriched near genes involved in blastocyst and stem cell regulation,and are often bound by master pluripotency TFs in blastocysts and embryonic stem cells(ESCs).Importantly,NR5A2 regulated key pluripotency genes Nanog and Pou5f1/Oct4,and primitive endoderm regulatory genes including Gata6 among many early ICM genes,as well as key trophectoderm regulatory genes including Tead4 and Gata3 at the 8C stage.By contrast,master pluripotency TFs NANOG,SOX2,and OCT4 targeted both early and late ICM genes in mouse ESCs.Taken together,these data identify NR5A2 as a key regulator in totipotent embryos that bridges ZGA to the first lineage segregation during mouse early development. | Fangnong Lai Lijia Li Xiaoyu Hu Bofeng Liu Ziqi Zhu Ling Liu Qiang Fan Huabin Tian Kai Xu Xukun Lu Qing Li Kong Feng Lijuan Wang Zili Lin Hongyu Deng Jinsong Li Wei Xie | 2023 | Cell Research2023，33，12： | 0 |
| 9 | Enhanced design of hourglass truss sandwich structures for compressive resistance显示文摘In this article,the design of the hourglass truss sandwich structure is improved by optimizing the number of layers to enhance the compressive strength of both the core and the face sheet and then its mechanical performance. The hourglass truss structures characterized by three different numbers of layers are manufactured using an interlocking and vacuum brazing method. The effect of the layer number of the hourglass core panels on their out-of-plane compression and in-plane compression performance is investigated,and the results from calculations and experiments are in reasonable agreement. The results show that as the layer number of the hourglass core increases,the out-of-plane compressive strengths show little change,but their energy absorption properties are effectively increased. The in-plane compressive failure mechanism maps are constructed,and the specimens are designed to examine the local elastic and inelastic buckling failure modes of the face sheets. The results suggest that as the number of layers of the hourglass core increases,its maximum in-plane compressive load increases. The maximum in-plane compressive loads of the two-layer hourglass truss panels are 57%–70% higher than those of the single-layer panels. It can also be concluded that the out-of-plane and in-plane compression mechanical properties of the multilayer hourglass truss outperform those of the pyramidal truss. Furthermore,the number of layers of the hourglass core is optimized in consideration of both mechanical properties and fabrication cost. | FENG LiJia YU GuoCai MA Li WU LinZhi ZHANG AMan | 2020 | Science China(Technological Sciences)2020，63，12： | 0 |
| 10 | Multi‐vital on‐skin optoelectronic biosensor for assessing regional tissue hemodynamics显示文摘Evaluation of the oxygen‐mediated effects of clinical and daily activities demands an on‐skin device that can track multi‐vital regional tissue hemodynamics simultaneously.For example,peripheral arterial disease(PAD)is the third most prevalent cardiovascular disease,but the means of diagnosing and monitoring this disease are limited because the affected area is usually in the non‐pulsatile area away from the heart.Herein,we report on an ultrathin and ultralight multi‐vital near‐infrared optoelectronic biosensor for the diagnosis and rehabilitation monitoring of regional tissue hemodynamics,which is suitable for mounting on the skin for long‐term measurement.The device can simultaneously detect tissue oxygen saturation,heart rate,arterial blood oxygen,and tissue perfusion and shows potential for various hypoxia monitoring applications.Moreover,the tissue hemodynamics detected by this device showed a highly accordance with the ankle‐brachial index and CT angiography obtained by traditional clinical methods.Therefore,our design was able to accurately diagnose and effectively evaluate PAD patients before and after surgery.The on‐skin optoelectronic biosensor shows potential in biological oxygen‐mediated behavior evaluation,injury‐state monitoring,PAD clinical diagnosis optimization,and after surgery care. | Ming Xin Tong Yu Yongchang Jiang Ruowen Tao Jiean Li Feng Ran Tangsong Zhu Jinrong Huang Jing Zhang Jia‐Han Zhang Nan Hu Wei Wang Qiuhong Zhang Zhao Liu Xinran Wang Yi Shi Lijia Pan | 2023 | SmartMat2023，4，3： | 0 |
| 11 | Cost Effective Scheme for OLT in Next Generation Passive Optical Access Network Based on Noise Free Optical Multi Carrier显示文摘We propos e a cos t-effective multi-carrier generation technique which minimizes the passive optical access network(PON) costs. In this study replacement of laser array with multi-carrier source at optical line terminal(OLT) side in PON is addressed. With 25-GHz frequency spacing, the generated optical multi-carriers exhibit good tone to noise ratio(TNR) i. e. above 20 d B, and least amplitude difference i. e. 1.5d B. At the OLT, multi-carriers signal based multiplexed differential phase shift keying(DPSK) data from all the channels each having 10 Gbps for downlink is transmitted through 25 km single mode fiber. While the transmitted information is retrieved at optical network unit(ONU), part of the downlink signal is re-modulated using intensity modulated(IM) on-off keying(OOK) for upstream transmission at 10-Gbps. Simulation results are in good agreement with the theoretical analysis, showing error free transmission in downlink and uplink with 10 Gbps symmetric data rate at each channel. The receivedpower, both for uplink and downlink transmission, is adequate for all channels at BER of 10-9 with minimum power penalties. Power budget is calculated for different splitting ratios showing excellent system margins for any unseen losses. The proposed setup provides a cost-effective way minimizing transmission losses, and providing greater system's margin in PON architecture. | Rahat Ullah Bo Liu Qi Zhang Qinghua Tian Amjad Ali Yousaf Khan Feng Tian M.Azam Zia Haseeb Ahmad Lijia Zhang Xiangjun Xin | 2016 | China Communications2016，13，6： | 0 |
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