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3篇 您的检索式：作者名="Bobby Mathew"

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		题名	作者	年代	出处	被引量
	1	Rickettsial seroepidemiology among farm workers, Tianjin, People' s Republic of China 显示文摘	Zhang LZ Ailan Shan Bobby Mathew	2008	Emerg Infect Dis2008，14，6：	1
	2	Model for tracing the path of microparticles in continuous flow microfluidic devices for 2D focusing via standing acous- tic waves 显示文摘	Bobby Mathew Anas Alazzam Bashar E1-Khasawneh	2015	Separation and Purification Technology2015，153，16：	1
	3	Microfluidic Immunoprecipitation for Post-Translational Modified Protein Purification显示文摘In this paper, we report an antibody functionalized microimmunopreci- pitation(μIP) method used for enrich lowabundant post-translational modified(PTM) proteins. The device is fabricated by inert, nontoxic and disposable polydimethylsiloxane(PDMS) using a silane-based chemical modification protocol, which yield antibody-terminated PDMS surfaces. In this study, the μIP device is specifically designed for the purification of carbonylated protein, a representative example here to illustrate the potential applications for any other PTMs, which could be immuno-tagged by specific antibodies. The test model in vitro oxidized bovine serum albumin(BSA) was first derivitized by dinitrophenylhydrazide(DNPH) and then captured by the anti-DNP immobilized on this μIP device. The surface functional group mapping was systematically analyzed and validated by fluorescence microscopy. Quantitative study of DNP-derivatized carbonylated protein capture recovery and elution efficiency of the device was also studied. We also envision that this proteome enrichment μIP device can be assembled with other lab-on-a-chip components, such as microelectrophoresis or micro-chromatographic devices for follow-up protein analysis. This selective enrichment of modified proteins greatly facilitates the study of low abundant protein biomarkers discovery.	XIA Hu Bobby Mathew Tom John Hisham Hegab June Feng	2012	Chinese Journal of Biomedical Engineering(English Edition)2012，21，2：	0

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