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| 1 | Treatment of early gastric cancer in the Western World显示文摘The incidence rate of gastric cancer is much higher in Asia than in the Western industrial nations.According to the different screening programs in Japan and Korea about fifty percent of treated patients had an early tumor stage.In contrast,European and American patients with gastric cancer had an advanced tumor stage.Therefore,the experience for the various therapeutic options for gastric cancer may be different between these regions.In this review we tried to point out the treatment modalities in Western industrial countries for early gastric cancer. | Elfriede Bollschweiler Felix Berlth Christoph Baltin Stefan Mnig Arnulf H Hlscher | 2014 | World Journal of Gastroenterology2014，20，19： | 8 |
| 2 | Pathohistological classification systems in gastric cancer:Diagnostic relevance and prognostic value显示文摘Several pathohistological classification systems exist for the diagnosis of gastric cancer.Many studies have investigated the correlation between the pathohistological characteristics in gastric cancer and patient characteristics,disease specific criteria and overall outcome.It is still controversial as to which classification system imparts the most reliable information,and therefore,the choice of system may vary in clinical routine.In addition to the most common classification systems,such as the Laurén and the World Health Organization(WHO)classifications,other authors have tried to characterize and classify gastric cancer based on the microscopic morphology and in reference to the clinical outcome of the patients.In more than 50 years of systematic classification of the pathohistological characteristics of gastric cancer,there is no sole classification system that is consistently used worldwide in diagnostics and research.However,several national guidelines for the treatment of gastric cancer refer to the Laurén or the WHO classifications regarding therapeutic decision-making,which underlines the importance of a reliable classification system for gastric cancer.The latest results from gastric cancer studies indicate that it might be useful to integrate DNA-and RNA-based features of gastric cancer into the classification systems to establish prognostic relevance.This article reviews the diagnostic relevance and the prognostic value of different pathohistological classification systems in gastric cancer. | Felix Berlth Elfriede Bollschweiler Uta Drebber Arnulf H Hoelscher Stefan Moenig | 2014 | World Journal of Gastroenterology2014，20，19： | 6 |
| 3 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 4 | Balancing cell adhesion and Wnt signaling, the key role of β-catenin显示文摘 | Felix H Brembeck Marta Rosário Walter Birchmeier | 2006 | Current Opinion in Genetics & Development2006，，1： | 2 |
| 5 | The antagonism of glueoeortieoid inhibition of wound healing in rats by growth hormone-releasing factor显示文摘 | Kelley S F Felix A M Ehrlieh H P | 1990 | Proe Soe Exp Biol Med1990，194，4： | 1 |
| 6 | Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derives macrophages显示文摘 | Cecchini MG Felix R Fleisch H | 1987 | J Bone Miner Res1987，2，2： | 1 |
| 7 | The in vitro effects of antithrombin Ⅲ on the activated coagulation time in patients on heparin therapy显示文摘 | Jerrold H Levy Felix Montes Fania Szlam | 2000 | Anesln Analg2000，90，： | 1 |
| 8 | Successful bronchoscopie placement of tracheobronchial stents without fluoroscopy显示文摘 | Felix H Heinrieh D Beeker | 2001 | Chest2001，119，6： | 1 |
| 9 | On the pathogenesis of Bell′s palsy显示文摘 | 1,Fish U Felix H | 1983 | Acta Otolaryngol1983，95，： | 1 |
| 10 | Prediction of metabolic syndrome by low serum testosterone levels in men:results from the study of health in Pomerania显示文摘 | Haring R Volzke H Felix SB | 2009 | Diabetes2009，58，9： | 1 |
| 11 | In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes 显示文摘 | Lachmann H J Lowe P Felix SD | 2009 | J Exp Med2009，206，： | 1 |
| 12 | Effectiveness of the Swiss Agri-Environment Scheme in Promoting Biodiversity显示文摘 | EVA K DAVID K FELIX H | 2006 | Journal of Applied Ecology2006，43，1： | 1 |
| 13 | Panhandle PCR:a technical advance to amplify MLL genomic translocation breakpoints显示文摘 | FELIX C A JONES D H | 1998 | Leukemia1998，12，6： | 1 |
| 14 | Fluorine containing beta-cyclodextrin:a new class of amphiphilic carriers显示文摘 | Granger C E Felix C P Parrot-Lopez H P | 2000 | Tetrahedron Letters2000，41，48： | 1 |
| 15 | Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle - stimulating hormone in controlled ovarian hypers- timulation : a prospective randomized blinded clinical tyial 显示文摘 | Barroso G Menocal G Felix H | 2006 | Fertil Steril2006，86，5： | 1 |
| 16 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 17 | Competitive anxiety and cortisol awakening response in the week leading up to a competition显示文摘 | Katharina S Felix E Moritz H | 2010 | Psychology of Sport and Exercise2010，11，2： | 1 |
| 18 | Multicriterion genetic optimization for due date assigned distribution network problems显示文摘 | FELIX T S CHAN S H CHUNG | 2005 | Decision Support Systems2005，39，： | 1 |
| 19 | Reversible polymers formed from self-complementary monomers using quadruple hydrogen bonding 显示文摘 | Rint P Sijbesma Felix H Berjer Luc Brunsveld | 1997 | Science1997，278，： | 1 |
| 20 | Design of a PCB plant with expert system and simulation approaeh 显示文摘 | Felix T S C Chan H K | 2008 | Expert Systems with Applieations2008，28，3： | 1 |
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