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| 1 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 2 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 3 | A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。 | Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo | 2017 | Cell Research2017，27，7： | 2 |
| 4 | COI1:An Arabidopsis gene required for jasmonate-regulated defense and fertility显示文摘 | Xie D X Feys B F James S | 1998 | Science1998，280，： | 2 |
| 5 | Effect of green tea polyphenols on dopamine uptake and on MPP ^+ -induced dopamine neuron injury显示文摘 | Pan T H Fei J Zhou X B | 2003 | Life Sci2003，72，： | 1 |
| 6 | Large-aperture YCOB Crystal Growth for Frequency Conversion in the High Average Power Laser System显示文摘 | Yifing Fei Chaia B H T Ebbers C A | 2006 | Journal of Crystal Growth2006，290，： | 1 |
| 7 | BambooGDB:a bamboo genome database with functional annotation and an analysis platform显示文摘 | Zhao H S Peng Z H Fei B H | 2014 | Database2014，，： | 1 |
| 8 | Synthesis and crystal structure of a luminescent infinite 2D brick-wall network with two- and three-coordinate silver (I) atoms and ligand-unsupported silver - silver interactions显示文摘 | Fei B L Sun W Y Okamura T | 2001 | New J Chem2001，25，： | 1 |
| 9 | Fault diagnosis of power transformer based on support vector machine with genetic algorithm 显示文摘 | Fei S W Zhang X B | 2009 | Expert Systems with Applications2009，36，11： | 1 |
| 10 | High electric conduction property of composite copper-clad steelwire显示文摘 | Fei B J Fei M B Chen Z H | 2001 | IEEE2001，15，6： | 1 |
| 11 | Automatic MR volume registration and its evaluation for the pelvis and prostate 显示文摘 | Fei B Wheaton A Lee Z | 2002 | Physics in Medicine and Biology2002，47，5： | 1 |
| 12 | COIl: an arabidopsis gene re?quired forJasmonate - regulated defense and fertility显示文摘 | Xie D X Feys B F James S | 1998 | Science1998，280，5366： | 1 |
| 13 | Coating Carbon Nanotubes by Spontaneous Oxidative Polymerization of Dopamine显示文摘 | Fei B Qian B Yang Z | 2008 | Carbon2008，46，10： | 1 |
| 14 | Non-rigid Multi-modal Image Registration Using Cross-cumulative Residual Entropy显示文摘 | Wang Fei Vemuri B C | 2007 | International Journal of Computer Vision2007，74，2： | 1 |
| 15 | Interplay of signaling pathways in plant disease resistance 显示文摘 | FEYS B J PARKER J E | 2000 | Trends Genet2000，16，10： | 1 |
| 16 | A new report of a mosaic dwarf viroid-like disease on mulberry trees in China显示文摘 | Wang W B Fei J M Wu Y | 2010 | Polish journal of microbiology2010，59，1： | 1 |
| 17 | Coating carbonnanotubes by spontaneous oxidative polymerization ofdopamine显示文摘 | FEI B QIAN B T YANG Z Y | 2008 | Carbon2008，46，13： | 1 |
| 18 | Preparation and Properties of Castor Oil/Pentaerythritol Triacy- late-based UV Curable Waterborne Polyurethane Ac- rylate 显示文摘 | LI K B SHEN Y D FEI G Q | 2015 | Prog in Org Coatings''2015，78，： | 1 |
| 19 | 3D ultrasound image segmentation using wavelet support vector machines显示文摘 | Akbari H Fei B | 2012 | Med Phys2012，39，6： | 1 |
| 20 | MicroRNA-638 inhibits cell prolifera- tion,invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma 显示文摘 | Zhang J Fei B Wang Q | 2014 | Oncotarget2014，23，12： | 1 |
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