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| 1 | Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation显示文摘AIM To investigate the prognostic value of the radiological response after transarterial chemoembolization(TACE)and inflammatory markers in patients affected by hepatocellular carcinoma(HCC)awaiting liver transplantation(LT).METHODS We retrospectively evaluated the preoperative pre dictors of HCC recurrence in 70 patients treated with conventional(n=16)or doxorubicin-eluting bead TACE(n=54)before LT.The patient and tumour characteristics,including the static and dynamic alpha-fetoprotein,neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio( LR)measurements,were recorded.Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours(m RECIST)and the European Association for the Study of the Liver(EASL)criteria as complete response(CR),partial response( R),stable disease o progressive disease.After examination of the explanted livers,histological necrosis was classified as complete(100%of the cumulative tumour area),partia(50%-99%)or minimal(<50%)and was correlated with the preoperative radiological findings.RESULTS According to the pre-TACE radiological evaluation,22/70(31.4%)and 12/70(17.1%)patients were beyond Milan and University of San Francisco(UCSF)criteria,respectively.After TACE procedures,the objective response(CR+ R)rates were 71.4%and 70.0%according to m RECIST and EASL criteria,respectively.The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response(weighted k-value:0.98 and 0.93,respectively).Complete and partial histological necrosis were achieved in 14/70(20.0%)and 28/70(40.0%)patients,respectively.Using histopathology as the reference standard,m RECIST criteria correctly classified necrosis in 72.9%(51/70)of patients and EASL criteria in 68.6%(48/70)of cases.The m RECIST non-response to TACE[Exp(b)=9.2, =0.012],exceeding UCSF criteria before TACE[Exp(b)=4.7, =0.033]and a preoperative LR>150[Exp(b)=5.9, =0.046]were independent predictors of tumour recurrence.CONCLUSION The radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT. | Daniele Nicolini Andrea Agostini Roberto Montalti Federico Mocchegiani Cinzia Mincarelli Alessandra Mandolesi Nicola L Robertson Roberto Candelari Andrea Giovagnoni Marco Vivarelli | 2017 | World Journal of Gastroenterology2017，23，20： | 4 |
| 2 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 3 | The magnitude of eopigmentation in the colour of aged red wines made in the Canary Islands 显示文摘 | Jacinto D M Marta C L Jose Federico E G | 2007 | Eur Food Res Techno12007，224，5： | 1 |
| 4 | Spatial and temporal divergence of expression in duplicatio barley Germin-like protein-encoding genes显示文摘 | Maria L Federico Ronald W Skadsen | 2006 | Genetics2006，174，： | 1 |
| 5 | Modal Acoustic Transfer Vector Approach in a FEMBEM Vibro-acoustic Analysis显示文摘 | CITARELLA R FEDERICO L CICATIELLO A | 2007 | Engineering Analysis with Boundary Elements2007，31，11： | 1 |
| 6 | Cloning of the promoter for a novel barley gene,Lem 1,and its organ-specific promotion of Gfp expression in lemma and palea 显示文摘 | Skadsen Ronald W Sathish Puthigae Federico Maria L | 2002 | Plant Molecular Biology2002，49，： | 1 |
| 7 | Genomic and transcriptomic analysis of the AP2/ERF superfamily in Vitis vinifera显示文摘 | FRANCESCO L FEDERICO G SARA Z | 2010 | BMC Genomics2010，11，： | 1 |
| 8 | Waste glass as a supplementary cementitious material in concrete -Criti- cal review of treatment methods显示文摘 | FEDERICO L M CHIDIAC S E | 2009 | Cement and Con- crete Composites2009，31，8： | 1 |
| 9 | Modal acoustic transfer vector approach in a FEM-BEM vibro-acoustic analysis 显示文摘 | CITARELLA R FEDERICO L CICATIELLO A | 2007 | Engineering Analysis with Boundary Elements2007，31，3： | 1 |
| 10 | Towards personalized recommendation by two-step modified apriori data mining algo- rithm 显示文摘 | Enrique L Federico B Antonio F C | 2008 | Expert System with Application2008，35，3： | 1 |
| 11 | Prognostic value of proton magnetic resonance spectroscopy in ischemic stroke显示文摘 | FEDERICO F SIMONE I L LUCIVERO V | 1999 | Arch Neurol1999，55，4： | 1 |
| 12 | Distribution of Notch protein members in normal and preeclampsia-complicated placentas显示文摘 | Cobellis L Mastrogiacomo A Federico E | 2007 | Cell Tissue Res2007，330，3： | 1 |
| 13 | Endoscopic endonasal approaches for repair of eerebrospinal fluid leaks : nine-year experience显示文摘 | Davide L Federico R Maurizio B | 2006 | Neurosurgery2006，58，2： | 1 |
| 14 | BRCA1 mutations and clinicopathological features in a sample of Italian women with early-onset breast cancer显示文摘 | Turchetti D Cortesi L Federico M | 2000 | Eur J Cancer2000，36，16： | 1 |
| 15 | Polymorphism in the α1-antichymotrypsin (ACT) gen promoter effect on expression in transfected glial and liver cell line and plasma ACT concentrations显示文摘 | Kevin M Federico L Louise T | 2001 | Hum Genet2001，109，： | 1 |
| 16 | Socio-economic inequalities in physical activity practice among Italian children and adolescents:a cross-sectional study显示文摘 | Federico B Falese L Capelli G | 2009 | Z Gesundh Wiss2009，17，6： | 1 |
| 17 | Distribution of Notch protein members in normal and preeclampsia-complicated placentas显示文摘 | Cobellis L Mastrogiacomo A Federico E | 2007 | Cell Tissue Res2007，330，3： | 1 |
| 18 | Heterogeneous alkene epoxidation: past, present and future显示文摘 | Richard M Iambert Federico J Williams Rachael L Cropley | 2005 | Journal of Molecular Catalysis A: Chemical2005，228，： | 1 |
| 19 | Modal acoustictransfer vector approach in a FEM-BEM vibro-acoustic analysis显示文摘 | Citarella R Federico L Cicatiello A | 2007 | Engineering Analysis with Boundary Ele- ments2007，31，3： | 1 |
| 20 | The least square prenueleolus and the least square nucleolus, two values for TU games based on the excess vector显示文摘 | Ruiz L M Federico Vahenciano Zarzue| J M | 1996 | In- ternational Journal of Game Theory1996，25，1： | 1 |
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