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| 1 | 新型重组腺病毒载体埃博拉疫苗完成1期临床试验显示文摘一种新型的重组5型腺病毒载体埃博拉疫苗完成了1期临床试验。研究结果显示了疫苗的安全性和免疫原型良好,特别是高剂量组在14d就可以产生高水平的特异性抗体和T细胞反应。此前的埃博拉疫苗毒株均来自1976年的扎伊尔(Zaire)埃博拉暴发疫情。来自中国的研究者首次评价了这种利用2014年埃博拉疫情流行毒株和重组5型腺病毒载体方法研制的新型埃博拉疫苗。 | Zhu FC Hou LH Li JX 索罗丹 | 2015 | 中华预防医学杂志2015，49，6： | 36 |
| 2 | Expression of the CagA gene of H.pylori and application of its product显示文摘INTRODUCTION Helicobaeter PYlori(HP)Plays an important role inthe uPPer digestive traet diseases.It can be dividedinto two main groups(toxie and non一toxieHP)aeeording to the | Han FC Yan XJ Su CZ | 2000 | World Journal of Gastroenterology2000，6，1： | 22 |
| 3 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 11 |
| 4 | FREDDY激光器的碎石效率的体外分析显示文摘背景和目的 双频双脉冲Nd :Yag(FREDDY)激光 (德国W .O .M .公司生产 )是一个短脉冲 ,双频率 ( 5 3 2nm和 10 64nm)的固体激光器。该激光器功率小 ,成本低 ,目前已在腔内碎石术中得到应用。我们设计了一个试验 ,以测试在不同能量和不同频率下的碎石效率。材料和方法 40个预先称过重量的硫酸钙石头被分成 4组 ,在 5Hz和 10Hz情况下 ,分别碎石 2min和 4min。一个水下的试验装置包括一个支架和一个容器 ,使得石英玻璃光纤可以直接抵住石头 ,发射激光。光纤被剥离成直径为 2 80 μm的裸露光纤 ,以保证最佳的能量传输。碎石完成后 ,所有的残余颗粒都落在容器内 ,晾干 48小时后 ,再重新称重 ,根据重量缺失的百分比来测试碎石效果。结果 5Hz时 ,碎石 2min的重量缺失为 2 4%;碎石 4min的重量缺失为 5 4%。 10Hz时 ,碎石 2min的情况与 5Hz时碎石 4min的结果相似 ,重量缺失为 5 1%;碎石 4min的重量缺失为 64 %,原先估计这么高的能量设置 ,重量缺失应该更大些。在高能量发射时 ,可以观察到光纤有损耗 ,这可能是导致碎石效率下降的原因。结论 FREDDY激光器在 5Hz时碎石 4min ,和在 10Hz时碎石 2min的效率是同等的 ,提示传输到结石的能量与碎石效率的相关性很好。而 10Hz、4min组的碎石效率比预期的略有下降 ,? | Delvecchio FC Auge BK Brizuela RM Weizer AZ Zhong P Preminger GM | 2004 | 国外医学(泌尿系统分册)2004，24，4： | 10 |
| 5 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 9 |
| 6 | Pattern response of dendritic cells in the tumor microenvironment and breast cancer显示文摘Breast cancer(BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development, including malignancy grade and patient prognosis, is influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological response. Among the immune response cells, dendritic cells(DCs) play a key role in the induction and maintenance of anti-tumor responses owing to their unique abilities for antigen cross-presentation and promotion of the activation of specific lymphocytes that target neoplasic cells. However, the tumor microenvironment can polarize DCs, transforming them into immunosuppressive regulatory DCs, a tolerogenicphenotype which limits the activity of effector T cells and supports tumor growth and progression. Various factors and signaling pathways have been implicated in the immunosuppressive functioning of DCs in cancer, and researchers are working on resolving processes that can circumvent tumor escape and developing viable therapeutic interventions to prevent or reverse the expression of immunosuppressive DCs in the tumor microenvironment. A better understanding of the pattern of DC response in patients with BC is fundamental to the development of specific therapeutic approaches to enable DCs to function properly. Various studies examining DCs immunotherapy have demonstrated its great potential for inducing immune responses to specific antigens and thereby reversing immunosuppression and related to clinical response in patients with BC. DCbased immunotherapy research has led to immense scientific advances, both in our understanding of the antitumor immune response and for the treatment of these patients. | Alessandra da Cunha Marcia A Michelin Eddie FC Murta | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 7 | Dot immunogold filtration assay for rapid detection of anti-HAV IgM in Chinese显示文摘INTRODUCTION The hepatitis A virus specific immunoglobulin M(IgM)antibody is a specific serological marker forearly diagnosis of hepatitis A..At present,themethods used at home or abroad for detecting anti-HAV IgM are RIA,ELISA and SPHAI.The dotimmunogold combination assay that has beendeveloped since 1989 is a new technique with theproperty of simple and rapid immunologicaldetection,by using the red colloidal gold particles tolabel the antibodies as indicator,and the | Han FC Hou Y Yan XJ Xiao LY Guo YH | 2000 | World Journal of Gastroenterology2000，6，3： | 5 |
| 8 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 9 | Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement显示文摘 | EM Horwitz K Le Blanc M Dominici I Mueller I Slaper-Cortenbach FC Marini RJ Deans DS Krause A Keating | 2005 | Cytotherapy2005，，5： | 2 |
| 10 | 盐敏感人群的血流动力学、水盐平衡与钠储存、血管功能障碍相关显示文摘该研究对8名盐敏感和13名盐抵抗正常血压受试者的盐负荷和损耗引起的24h血流动力学变化进行评估。盐负荷后,与盐抵抗组人群比较,盐敏感组受试者由于总外周血管阻力[(1791±148)比(1549±66)dyn/(cm·s),P=0.05]较高,从而平均动脉压[(96.5±2.8)比(84.2±2.7)mm Hg,1 mm Hg=0.133kPa,P〈0.01]也增高;而两组人群心输出量差异无统计学意义[盐敏感(4.5±0.3)比盐抵抗(4.4±0.2)L/min]。 | 刘莉 叶鹏 Laffer CL Scott RC 3rd Titze JM Luft FC Elijovich F | 2016 | 中华高血压杂志2016，24，5： | 2 |
| 11 | Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats显示文摘 | Wang X Barone FC | 1997 | Stroke1997，28，： | 2 |
| 12 | Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain显示文摘 | Liu D Smith CL Barone FC | 1999 | Mol Brain Res1999，68，： | 2 |
| 13 | Left ventricular diastolic function parameters after PTCA and stent implantation显示文摘 | Schannwell CM Schoebel FC Schmitz M | 2001 | Z Kardiol2001，90，9： | 2 |
| 14 | Mechanistic Aspects of the Selective Reduction of NO By Propene Over Alumina and Silver-Alumina Catalysts显示文摘 | Meunier FC Breen JP Zuzaniuk V | 1999 | Journal of Catalysis1999，187，： | 2 |
| 15 | Effect of the silver loading and some other experimental parameters on the selective reduction of NO with C3H6 over Al2O3 and ZrO2-based catalysts 显示文摘 | Meunier FC Ukropec R Stapleton C | 2001 | Applied Catalysis B: Environmental2001，30，： | 2 |
| 16 | On the nature of the silver phases of Ag/Al2O3 catalysts for reactions involving nitric oxide 显示文摘 | Bogdanchikova N Meunier FC Avalos-Borja M | 2002 | Applied Catalysis B: Environmental2002，36，4： | 2 |
| 17 | Cytochrome P-4503A1 catalyzes the formation of MA1 from territrem a in liver microsomes of 7-week-old female Wistar rats显示文摘 | Lin SW Jean WC Peng FC | 2003 | J Toxicol Environ Health A2003，66，： | 2 |
| 18 | Perineal repair of posterior urethral stricture and clefect: experience in 79 cases in the last 5-year显示文摘 | Flynn BJ Delvecchio FC Webster GD | 2002 | J Urol2002，，： | 2 |
| 19 | Cytokines,inflammation and brain injury:role of tumor necrosis factor-α显示文摘 | Feuerstein GZ Liu T Barone FC | 1994 | Cerebrovasc Brain Metab Rev1994，6，： | 2 |
| 20 | Human hepatopoietin and its relationship with liver regeneration显示文摘IT is nothing.new to see the regeneration of affiliated organs or limbs in the lower living beings. However, the regeneration ability in higher mammals is extremely limited. Therefore,the regeneration ability possessed peculiarly by mammal liver attracts great attention. That solely high regeneration ability has been discovered for thousands of years and yet the studies on the mechanism were initiated only a hundred years ago. The key breakthrough happened in 1931 when Higgins and Anderson established the hepatic regeneration model by partial hepatectomy in rats. Since then, the successive studies on liver regeneration mechanism have been focused on analysis and identification of the events initiating the regenerative process. | He, FC Wu, ZZ | 1997 | Chinese Science Bulletin1997，42，18： | 2 |
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