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| 1 | Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells显示文摘Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenininduced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (ADP-ribose) polymerase cleavage. Diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied. | Cecile CORBIERE Bertrand LIAGRE Faraj TERRO Jean-Louis BENEYTOUT | 2004 | Cell Research2004，14，3： | 29 |
| 2 | Clinical features and treatment of sump syndrome following hepaticojejunostomy显示文摘BACKGROUND:Cholangitis after Roux-en-Y hepaticojejunostomy is usually caused by anastomotic stricture.A small number of cases present without evidence of obstruction and are ascribed to reflux of gastro-intestinal content into the biliary tree above the anastomosis (sump syndrome).Despite prophylactic rotating antibiotic therapy,the cholangitic episode may be severe and life-threatening.METHODS:From 2001 to 2006,six patients who had undergone an end-to-side hepaticojejunostomy presented to our institution with recurrent episodes of biliary sepsis.Anastomotic stricture was excluded by liver MRI/MRCP and percutaneous transhepatic cholangiogram (PTC).Barium meal showed reflux of contrast into the biliary tree in all patients.Three patients had a short jejunal Roux limb (less than 50 cm) on pre-operative imaging.RESULTS:Five patients underwent surgery and two of them had two operations.One patient had a Tsuchida antireflux valve and subsequently underwent lengthening of the Roux loop.Three patients had lengthening of the Roux loop;one underwent re-do hepaticojejunostomy and one had concomitant revision of the hepaticojejunostomy and lengthening of the Roux loop.The latter underwent further lengthening of the Roux loop.Three patients are cholangitis-free 6,36 and 60 months after surgery;two still experience mild episodes of cholangitis.CONCLUSIONS:An adequate length of the Roux loop is important to prevent reflux.However,Roux loop lengthening to 70 cm or more does not always resolve the problem and cholangitis,although generally less frequent and severe,may recur despite appropriate reconstructive or antireflux surgery.In these cases,life-long rotating antibiotics is the only available measure. | Gabriele Marangoni Amir Ali Walid Faraj Nigel Heaton Mohamed Rela | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 3 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 4 | LDL,LDL receptors,and PCSK9 as modulators of the risk for type 2 diabetes:a focus on white adipose tissue显示文摘Type 2 diabetes(T2D) and cardiovascular disease(CVD) share many risk factors such as obesity,unhealthy lifestyle,and metabolic syndrome,whose accumulation over years leads to disease onset.However,while lowering plasma low-density lipoprotein cholesterol(LDLC) is cardio-protective,novel evidence have recognised a role for common LDLC-lowering variants(e.g.in HMGCR,PCSK9,and LDLR) and widely used hypocholesterolemic drugs that mimic the effects of some of these variants(statins) in higher risk for T2D.As these conditions decrease plasma LDLC by increasing tissue-uptake of LDL,a role for LDL receptor(LDLR)pathway was proposed.While underlying mechanisms remain to be fully elucidated,work from our lab reported that native LDL directly provoke the dysfunction of human white adipose tissue(WAT) and the activation of WAT NLRP3(Nucleotide-binding domain and Leucine-rich repeat Receptor,containing a Pyrin domain 3)inflammasome,which play a major role in the etiology of T2D.However,while elevated plasma numbers of apolipoprotein B(apoB)-containing lipoproteins(measured as apoB,mostly as LDL) is associated with WAT dysfunction and related risk factors for T2D in our cohort,this relation was strengthened in regression analysis by lower plasma proprotein convertase subtilisin/kexin type 9(PCSK9).This supports a central role for upregulated pathway of LDLR and/or other receptors regulated by PCSK9 such as cluster of differentiation 36(CD36) in LDL-induced anomalies.Targeting receptor-mediated uptake of LDL into WAT may reduce WAT inflammation,WAT dysfunction,and related risk for T2D without increasing the risk for CVD. | May Faraj | 2020 | The Journal of Biomedical Research2020，34，4： | 2 |
| 5 | Information Technology and the Changing Fabric of Organization显示文摘 | Raymond F. Zammuto Terri L. Griffith Ann Majchrzak Deborah J. Dougherty Samer Faraj | 2007 | Organization Science2007，，5： | 2 |
| 6 | “It is what one does”: why people participate and help others in electronic communities of practice显示文摘 | M. McLure Wasko S. Faraj | 2000 | Journal of Strategic Information Systems2000，，2： | 2 |
| 7 | Empirical relationship for frequency content parameters of earthquake ground motions 显示文摘 | Rathje E M Faraj F Russell S | 2004 | Earthquake Spectra2004，20，1： | 1 |
| 8 | Anterior instrumentation for the treatment of spinal tuberculosis 显示文摘 | Faraj AA | 1999 | J Bone Joint Surg (Am)1999，81，9： | 1 |
| 9 | The use of a hook-plate in the management of acremieclavicular injuries:report of ten cases显示文摘 | Faraj AA Ketzer B | 2001 | Acta Orthop Belg2001，67，： | 1 |
| 10 | Coordinating Expertise in Soft- ware Development Teams 显示文摘 | FARAJ S SPROULL L | 2000 | Management Science2000，46，12： | 1 |
| 11 | Penetration injury of the hindfoot following intramedullary nail fixation of a tibial fracture显示文摘 | Faraj AA Johnson VO | 2002 | Acta Orthop Belgica2002，68，2： | 1 |
| 12 | Why Should We Share? Examining Social Capital and Knowledge Contribution In Elec~'onic Networks of Practice显示文摘 | Wasko M M Faraj S | 2005 | MIS Quarterly2005，29，1： | 1 |
| 13 | Coordinating expertise in software development teams 显示文摘 | FARAJ S SPROULL L | 2000 | Management Science2000，46，12： | 1 |
| 14 | Why Should I Sharing? Examining Social Capital and Knowledge Contribution in Electronic Networks of Practice显示文摘 | Wasko M M Faraj S | 2005 | MIS Quarterly2005，29，1： | 1 |
| 15 | Arthroscopic findings in the knee of pre-adolescent children:report of 23 cases显示文摘 | Faraj AA Schilders E Martens M | 2000 | Arthroscopy2000，16，8： | 1 |
| 16 | 'It Is What One Does' :Why PeopleParticipate and Help Others in Electronic Communities of Practice 显示文摘 | MclurewaskoM Faraj S | 2000 | The Journal of Strategic Information Systems2000，9，2： | 1 |
| 17 | Boundary Work in Knowledge Teams显示文摘 | Faraj S Yan A | 2009 | Journal of Applied Psychology2009，94，3： | 1 |
| 18 | Anterior instrumentation for the treatment of spinal tuberculosis显示文摘 | Faraj AA | | 0，，： | 1 |
| 19 | An industry foundationclasses web-based collaborative construction computerenvironment : WISPER显示文摘 | Faraj I Alshawi M Aouad G | 2000 | Automation in Construction2000，10，1： | 1 |
| 20 | Does position of syndesmotic screw affect functional and radiologieal outcome in ankle fractures?显示文摘 | Kukreti S Faraj A Miles JN | 2005 | Injury2005，36，9： | 1 |
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