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| 1 | Nuclearly Encoded Splicing Factors Implicated in RNA Splicing in Higher Plant Organelles显示文摘植物细胞器从二个独立 endosymbiosis 事件产生了。在整个进化历史,叶绿体和线粒体的紧密的控制被原子核获得了,它调整细胞器染色体表示和新陈代谢的大多数步。特别地,包括拼接的 RNA, RNA 成熟高度依赖于原子地编码的拼接的因素。在细胞器的大多数 introns 是组 II introns,其催化机制非常类似于原子 spliceosome 的。植物组 II introns 失去了能力到在 vivo 自我拼接并且作为余因子要求原子地编码的蛋白质。自从首先拼接,因素在叶绿体被识别超过 10 ? 年以前,许多另外的蛋白质被显示了涉及在叶绿体或线粒体至少一 introns 拼接。这些新蛋白质属于 RNA 有约束力的蛋白质的许多不同家庭并且在细胞器提供新卓见进 ribonucleoprotein 建筑群和 RNA 拼接机械。在这评论,我们描述怎么拼接的因素,由原子核编码了并且指向了到细胞器,在更高的植物细胞器参加 post-transcriptional 步骤基因表示。我们继续讨论潜力让这些因素调整细胞器基因表示。 | Andeol Falcon de Longevialle lan D. Small Claire Lurin | 2010 | Molecular Plant2010，3，4： | 11 |
| 2 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 3 | Impacts of El Nino-Southern Oscillation events on China's rice production显示文摘This paper aims to demonstrate the relationships between ENSO and rice production of Jiangxi province in order to identify the reason that ENSO might have little effect on Chinese rice production. Using a data set with measures of Jiangxi's climate and rice production,we find the reason that during 1985 and 2004 ENSO's well correlated with rainfall did not promote Chinese rice production. First,the largest effects of ENSO mostly occur in the months when there is no rice in the field. Second,there is almost no temperature effect. Finally,the monthly distribution of rainfall is almost the same in ENSO and neutral years because the largest effects are during months when there is the least rain. In addition,due to the high irrigation share and reliable and effective irrigation facilities of cultivated land,China's rice production is less climate-sensitive. | DENG Xiangzheng HUANG Jikun QIAO Fangbin Rosamond L. Naylor Walter P. Falcon Marshall Burke Scott Rozelle David Battisti | 2010 | Journal of Geographical Sciences2010，20，1： | 7 |
| 4 | Flavonols Protect Arabidopsis Plants against UV-B Deleterious Effects显示文摘 | Julia Emiliani Erich Grotewold María Lorena Falcone Ferreyra Paula Casati | 2013 | Molecular Plant2013，6，4： | 6 |
| 5 | Transition from wavelets to ripples in a laboratory flume with a diverging channel显示文摘An experimental investigation on the initiation and development of bed forms on a bed of fine silica sand was conducted under alluvial flow conditions in a laboratory flume with a diverging channel. The main aims of the study were to assess: i) the steepness of bed forms in the transition stage of development; and ii) the threshold height of wavelets (ηt) that triggered the start of ripple development. Detailed bed profile measurements were carried out using an acoustic Doppler probe, traversed longitudinally over the sediment bed at various experimentation times. The bed form dimensions were extracted from such bed profile records and analysed for the wavelet, transition and equilibrium stages. It was found that the steepness of ripples in the transition and equilibrium stages were similar, confirming predictions of previous mathematical model simulations. A lognormal distribution fitted the wavelet length data. The wavelet threshold height was estimated as ηt≈ 7 mm, or y+ ≈ 80 in wall units. Such a height magnitude suggested that ripple development could be triggered by the wavelets reaching the outer flow zone of a turbulent boundary layer. The ηt value obtained corresponded generally to the intersection point between two predictive equations for bed form dimensions. A formulation was developed to predict ηt as a function of the sediment grain size, which was confirmed for the fine sand used in this study. | William B. RAUEN Binliang LIN Roger A. FALCONER | 2008 | International Journal of Sediment Research2008，23，1： | 5 |
| 6 | Laparoscopic management of intra-abdominal infections:Systematic review of the literature显示文摘AIM: To investigate the role of laparoscopy in diagnosis and treatment of intra abdominal infections.METHODS: A systematic review of the literature was performed including studies where intra abdominal infections were treated laparoscopically.RESULTS: Early laparoscopic approaches have become the standard surgical technique for treating acute cholecystitis. The laparoscopic appendectomy has been demonstrated to be superior to open surgery in acute appendicitis. In the event of diverticulitis, laparoscopic resections have proven to be safe and effective procedures for experienced laparoscopic surgeons and may be performed without adversely affecting morbidity and mortality rates. However laparoscopic resection has not been accepted by the medical community as the primary treatment of choice. In high-risk patients, laparoscopic approach may be used for exploration or peritoneal lavage and drainage. The successful laparoscopic repair of perforated peptic ulcers for experienced surgeons, is demonstrated to be safe and effective. Regarding small bowel perforations, comparative studies contrasting open and laparoscopic surgeries have not yet been conducted. Successful laparoscopic resections addressing iatrogenic colonic perforation have been reported despite a lack of literature-based evidence supporting such procedures. In post-operative infections, laparoscopic approaches may be useful in preventing diagnostic delay and controllingthe source.CONCLUSION: Laparoscopy has a good diagnostic accuracy and enables to better identify the causative pathology; laparoscopy may be recommended for the treatment of many intra-abdominal infections. | Federico Coccolini Cristian Tranà Massimo Sartelli Fausto Catena Salomone Di Saverio Roberto Manfredi Giulia Montori Marco Ceresoli Chiara Falcone Luca Ansaloni | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 5 |
| 7 | Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review显示文摘Despite advances in the management of patients with locally advanced,non-metastatic rectal adenocarcinoma(LARC),prognosis remains largely unsatisfactory due to a high rate of distant relapse.In fact,currently available neoadjuvant protocols,represented by fluoropyrimidine-based chemo-radiotherapy(CT-RT)or short-course RT,together with improved surgical techniques,have largely reduced the risk of local relapse,with limited impact on distant recurrence.Available results of phaseⅢtrials with additional cytotoxic agents combined with standard CT-RT are disappointing,as no significant reduction in the risk of recurrence has been demonstrated.In order to improve the control of micrometastatic disease,integrating targeted agents into neoadjuvant treatment protocols thus offers a rational approach.In particular,the antiangiogenic agent bevacizumab has demonstrated synergistic activity with both CT and RT in pre-clinical and clinical models,and thusmay represent a suitable companion in the neoadjuvant treatment of LARC.Preliminary results of phase?Ⅰ-Ⅱclinical studies are promising and suggest potential clinical parameters and molecular predictive biomarkers useful for patient selection:treatment personalization is indeed the key in order to maximize the benefit while reducing the risk of more complex neoadjuvant treatment schedules. | Lorenzo Fornaro Chiara Caparello Caterina Vivaldi Virginia Rotella Gianna Musettini Alfredo Falcone Editta Baldini Gianluca Masi | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 8 | Electrostatic concentration of phosphate flotation concentrate显示文摘The concentration of phosphate flotation concentrate with P2O5 grade lower than the commercially acceptable phosphate quality was upgraded in the use of tribo-electrostatic technique. The concentration of the flotation concentrate stream was conducted under both triboelectrification and inductive charging mechanism. Mineralogical analysis reveals that the phosphate ore utilized was dominated mainly by fluorapatite, crandallite, wavellite, and with quartz as the major gangue mineral. Flotations concentrate of about 28.87% P2O5 was obtained from the reverse flotation technique, after conditioning the phosphate ore at 80% passing 150 lm under Lilafloat. Constant parameters such as à6 kV charging voltage, 25 kV separating voltage, inlet air, different charger rotary speed and splitter distances were investigated. Commercially accepted grade of 35.50% P2O5 was attained after the second stage of separation with a recovery of 12.26%, another phosphate product of 34.02% P2O5 and 85.19% was also recovered under the same condition. Single stage of separation also shows a significant increase in the grade of the product obtained, with 33.41% P2O5 and 84.07% recovery achievable. The practicability of tribo-electrostatic separation technique for upgrading flotation concentrates resulted in a significant increase in grade for <150 lm product that do not meet the viable grade. | Bada Samson Gcanga Sandi Falcon Lionel Falcon Rosemary Makhula Mpho | 2013 | International Journal of Mining Science and Technology2013，23，3： | 4 |
| 9 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 10 | 氯接触池中溶质输移与消毒过程的数值模拟显示文摘为使饮用水处理中氯接触池达到较高的掺混和消毒效率 ,提出一种数学模拟方法。采用二维水流动量方程和连续方程、自由氯的反应过程一阶动力学方程和细菌数量衰减过程的 Chick- Watson公式等组成的模型 ,计算了氯接触池中溶质输移与消毒过程。对 3种涡粘性湍流模型与 3种差分格式的不同组合下计算所得到的多组模拟结果进行了分析 ,并与试验数据进行了比较。研究表明 :通过数值方法对池内的水流紊动结构及自由氯输运、反应和细菌生灭等过程进行计算模拟 ,与仅依据不同设计方案所得滞留曲线进行评价的做法相比 ,更有利于比较内部细节的设计 。 | 王虹 邵学军 FALCONER RogerA. | 2004 | 清华大学学报(自然科学版)2004，44，6： | 3 |
| 11 | Cirrhotic Patients Are at Risk for Health Care–Associated Bacterial Infections显示文摘 | Manuela Merli Cristina Lucidi Valerio Giannelli Michela Giusto Oliviero Riggio Marco Falcone Lorenzo Ridola Adolfo Francesco Attili Mario Venditti | 2010 | Clinical Gastroenterology and Hepatology2010，，11： | 3 |
| 12 | The Severn Barrage and other tidal energy options:Hydrodynamic and power output modelling显示文摘Details are given herein of the current main proposals for tidal energy provision from the Severn Estuary, in the UK, with particular emphasis being focused on the Severn Barrage project, as originally promoted by the Severn Tidal Power Group. In particular, emphasis has focused on assessing the potential hydro-environmental impacts and power outputs of a barrage across the estuary, with an unstructured grid, high resolution, model being developed and applied to the estuary to assess the implications of each of five shortlisted proposed schemes on the hydrodynamic, geomorphologic, flood risk and faecal indicator organism changes within the estuary. An outline is given of recent research on power refinements to the model to assess the options for power generation. The results show that the Severn Barrage has the potential to reduce the tidal currents in a highly dynamic estuary. This leads to the reduction of suspended sediment loads (particularly upstream of the barrage), an increase of light penetration within the water column and, potentially, an increase in the benthic bio-diversity and the level of aquatic life in the estuary. The results also show that the Severn Barrage will reduce markedly the risk of flooding upstream of the barrage and to a lesser extent downstream of the structure. In contrast the alternative options have far less impact on flood risk changes. In addition to the Severn Barrage some results are shown herein for a typical lagoon option, namely the Fleming Lagoon. | Roger A. Falconer Reza Ahmadian | 2009 | Science China(Technological Sciences)2009，52，11： | 3 |
| 13 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 14 | Statistical analysis and concentration of iron ore using Longi LGS 500 WHIMS显示文摘A Longi LGS 500 wet high intensity magnetic separator(WHIMS) was used to concentrate a fine, low grade South African hematite ore. The ore was prepared into different size fractions and was subjected to changes in pulp density, magnetic field intensity and pulsation frequency which followed a 33 full factorial matrix. The concentrate mass yield and Fe grade were selected as the dependent responses to the changes. The analysis of variance(ANOVA) shows that the variables investigated are significant to the material's response to magnetic separation. This significance was in the order of magnetic field intensity followed by pulsation frequency and then pulp density. It was also noted that a single stage magnetic separation has a potential to upgrade a feed( 75 lm and 40% Fe) to a 55% Fe grade, as the pulsation frequency increases. In addition, the model predictions and actual data were in good agreement, reporting regression coefficients within acceptable ranges. | Makhula M.J. Falcon R.M.S. Bergmann C.P. Bada S.O. | 2016 | International Journal of Mining Science and Technology2016，26，5： | 2 |
| 15 | The Relationship between Magnetic Gradient and Magnetic Shear in Five Super Active Regions Producing Great Flares显示文摘We study the magnetic structure of five well-known active regions that produced great flares (X5 or larger). The six flares under investigation are the X12 flare on 1991 June 9 in AR 6659, the X5.7 flare on 2000 July 14 in AR 9077, the X5.6 flare on 2001 April 6 in AR 9415, the X5.3 flare on 2001 August 25 in AR 9591, the X17 flare on 2003 October 28 and the X10 flare on 2003 October 29, both in AR 10486. The last five events had corresponding LASCO observations and were all associated with Halo CMEs. We analyzed vector magne-tograms from Big Bear Solar Observatory, Huairou Solar Observing Station, Marshall Space Right Center and Mees Solar Observatory. In particular, we studied the magnetic gradient derived from line-of-sight magnetograms and magnetic shear derived from vector magne-tograms, and found an apparent correlation between these two parameters at a level of about 90%. We found that the magnetic gradient could be a better proxy than the shear for predicting where a major flare might occur: all six flares occurred in neutral lines with maximum gradient. The mean gradient of the flaring neutral lines ranges from 0.14 to 0.50 G km-1, 2.3 to 8 times the average value for all the neutral lines in the active regions. If we use magnetic shear as the proxy, the flaring neutral line in at least one, possibly two, of the six events would be mis-identified. | Hai-Min Wang Hui Song Ju Jing Vasyl Yurchyshyn Yuan-Yong Deng Hong-Qi Zhang David Falconer Jing Li | 2006 | Chinese Journal of Astronomy and Astrophysics2006，6，4： | 2 |
| 16 | 利用测评工具改进课堂教学——以物理学科为例显示文摘一直以来,一些由科学、数学和教育工作者组成的专业团体,呼吁要大力改革科学与数学教学。他们在报告中批评美国的科学和数学教学前后不连贯、内容过度重复、主题不突出,用他们的话说就是“泛而不精”。 | Dan MacIsaac Kathleen Falconer 吴维宁 | 2013 | 教育测量与评价(理论版)2013，，2： | 2 |
| 17 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 18 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 19 | 构建洪水精准数值模型显示文摘洪水是由大量降雨造成的一个自然过程,并且会导致水污染,很多地方因为洪水爆发之后的疫情,造成人员死亡,所以今后应该把水利、水文、流行病以及生物学结合在一起,各领域专家都参与到城市防洪工作中。 | Roger Falconer | 2018 | 中国防汛抗旱2018，28，2： | 2 |
| 20 | Development of an integrated model for assessing the impact of diffuse and point source pollution on coastal waters显示文摘 | YUAN D LIN B FALCONER R A | 2007 | Environmental Modelling & Software2007，22，： | 1 |
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