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| 1 | Microbiota and the gut-liver axis:Bacterial translocation,inflammation and infection in cirrhosis显示文摘Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota.In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria(i.e.,gram negative species)and a decrease in autochthonous familiae.Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences.We therefore described the features of the complex interaction between gut microbiota and cirrhotic host,the so called'gut-liver axis',with a particular attention to the acquired risk of bacterial translocation,systemic inflammation and the relationship with systemic infections in the cirrhotic patient.Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis. | Valerio Giannelli Vincenza Di Gregorio Valerio Iebba Michela Giusto Serena Schippa Manuela Merli Ulrich Thalheimer | 2014 | World Journal of Gastroenterology2014，20，45： | 43 |
| 2 | Follow-up of intestinal metaplasia in the stomach: When, how and why显示文摘Gastric cancer remains the second most frequent cause of cancer-related mortality in the world. Screening programs in some Asian countries are impractical in the majority of other countries worldwide. Therefore, follow-up of precancerous lesions is advisable for secondary gastric cancer prevention. Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy. The IM prevalence rate is significantly higher in patients with Helicobacter pylori (H. pylori) infection, in first-degree relatives of gastric cancer patients, in smokers and it increases with patient age. IM is the 'breaking point' in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression. Gastric cancer risk is higher in patients with incomplete-type IM, in those with both antral and gastric body involvement, and the risk significantly increases with IM extension over 20% of the gastric mucosa. Scheduled endoscopic control could be cost-effective in IM patients, depending on the yearly incidence of gastric cancer in IM patients, the stage of gastric cancer at diagnosis discovered at surveillance, and the cost of endoscopy. As a pragmatic behavior, yearly endoscopic control would appear justified in all IM patients with at least one of these conditions: (1) IM extension > 20%; (2) the presence of incomplete type IM; (3) first-degree relative of gastric cancer patients; and (4) smokers. In the remaining IM patients, a less intensive (2-3 years) could be proposed. | Angelo Zullo Cesare Hassan Adriana Romiti Michela Giusto Carmine Guerriero Roberto Lorenzetti Salvatore MA Campo Silverio Tomao | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 25 |
| 3 | Changes in nutritional status after liver transplantation显示文摘Chronic liver disease has an important effect on nutritional status, and malnourishment is almost universally present in patients with end-stage liver disease who undergo liver transplantation. During recent decades,a trend has been reported that shows an increase in number of patients with end-stage liver disease and obesity in developed countries. The importance of carefully assessing the nutritional status during the workup of patients who are candidates for liver replacement is widely recognised. Cirrhotic patients with depleted lean body mass(sarcopenia) and fat deposits have an increased surgical risk; malnutrition may further impact morbidity, mortality and costs in the post-transplantation setting. After transplantation and liver function is restored, many metabolic alterations are corrected,dietary intake is progressively normalised, and lifestyle changes may improve physical activity. Few studies have examined the modifications in body composition that occur in liver recipients. During the first 12 mo, the fat mass progressively increases in those patients who had previously depleted body mass, and the muscle mass recovery is subtle and non-significant by the end of the first year. In some patients, unregulated weight gain may lead to obesity and may promote metabolicdisorders in the long term. Careful monitoring of nutritional changes will help identify the patients who are at risk for malnutrition or over-weight after liver transplantation. Physical and nutritional interventions must be investigated to evaluate their potential beneficial effect on body composition and muscle function after liver transplantation. | Michela Giusto Barbara Lattanzi Vincenza Di Gregorio Valerio Giannelli Cristina Lucidi Manuela Merli | 2014 | World Journal of Gastroenterology2014，20，31： | 5 |
| 4 | Cirrhotic Patients Are at Risk for Health Care–Associated Bacterial Infections显示文摘 | Manuela Merli Cristina Lucidi Valerio Giannelli Michela Giusto Oliviero Riggio Marco Falcone Lorenzo Ridola Adolfo Francesco Attili Mario Venditti | 2010 | Clinical Gastroenterology and Hepatology2010，，11： | 3 |
| 5 | 自媒体在中国:对参与式新闻的初步观察与思考显示文摘自媒体在中国的实践和发展为'参与式新闻'的理论构建和实践提供了宝贵的素材。中国的参与式新闻有着自己的生态演进过程,传统媒体人的工作方式、身份、心态等也随着媒介生态的演进悄然发生改变;中国人的智慧使得新闻生产与再生产的机制灵活多样,形式活泼;中国自媒体的商业化还在进一步探索之中,商业操作与金融手段运用日趋成熟,潜力巨大;中国政府对自媒体的治理和运用为世界各国政府提供了宝贵经验。 | Alice Giusto 周慎 | 2017 | 传媒2017，，10： | 2 |
| 6 | 显示文摘 | Di Giusto DA King GC | 2004 | J Biol Chem2004，279，46： | 1 |
| 7 | Expression and function of Oatl and Oat3 in rat kidney exposed to mercuric chloride显示文摘 | Di Giusto G Anzai N Ruiz M L | 2009 | Arch Toxicol2009，83，： | 1 |
| 8 | Optical properties of interstellar grain aggregates显示文摘 | IAT M A SAIJA R GIUSTO A | 2004 | Journal of Quantitative Spectroscopy & Radiative Transfer2004，89，14： | 1 |
| 9 | Protease-Activated Receptor-2 Activation in Gastric Cancer Cells Promotes Epidermal Growth Factor Receptor Trans -Activation and Proliferation显示文摘 | Roberta Caruso Francesco Pallone Daniele Fina Valentina Gioia Ilaria Peluso Flavio Caprioli Carmine Stolfi Alessandra Perfetti Luigi Giusto Spagnoli Giampiero Palmieri Thomas T. MacDonald Giovanni Monteleone | 2006 | The American Journal of Pathology2006，，1： | 1 |
| 10 | Non-specific adsorption on antibody surfaces for immunosensing显示文摘 | Ahluwalia A Giusto G De Rossi D | 1995 | Mat Sei Engin C1995，，3： | 1 |
| 11 | Single base extension (SBE) with proofreading polymerases and phosphorothioate primers:improved fidelity in single-substrate assays显示文摘 | Di Giusto D King GC | 2003 | Nucleic Acids Res2003，31，3： | 1 |
| 12 | Conversion from twice-daily to once-daily tacrolimus administration in liver transplant patient显示文摘 | Medi M Di Menna S Giusto M | 2010 | Transplant Proc2010，42，4： | 1 |
| 13 | Antiviral activity of amantadine in elderly patients with chronic hepatitis C显示文摘 | Torre F Campo N Giusto R | 2001 | Gerontology2001，47，6： | 1 |
| 14 | Extracranial thrombotically active carotid plaque as a risk factor for ischemic stroke显示文摘 | Luigi Giusto Spagnoli Alessandro Mauriello | 2004 | Extracranial Plaque And Ischemic Stroke2004，292，122： | 1 |
| 15 | Transjugular Liver Biopsy: Comparison of Sample Adequacy with the Use of Two Automated Needle Systems显示文摘 | George Behrens Hector Ferral Deborah Giusto Jay Patel David H. Van Thiel | 2011 | Journal of Vascular and Interventional Radiology2011，，3： | 1 |
| 16 | A multi-factors approach for image quality assessment based on a human visual system model显示文摘 | GINESU G MASSIDDA F GIUSTO D D | 2006 | Signal Processing:Image Communication2006，21，4： | 1 |
| 17 | Lipid metabolism in vertebrate retinal rod outer segments 显示文摘 | Giusto N M Pasquare S J Salvador P I | 2000 | Prog Lipid Res2000，39，： | 1 |
| 18 | Nutritional status: its influ- ence on the outcome of patients undergoing liver transplantation 显示文摘 | Merli M Giusto M Gentili F | 2010 | Liver International2010，30，2： | 1 |
| 19 | Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3 beta pathway in synaptic endings from adult and aged rats显示文摘 | Uranga RM Giusto NM Salvador GA | | 0，，： | 1 |
| 20 | Activation of phosphoinositide-3 kinase/ Akt pathway by FeSO4 in rat cerebral cortex synaptic endings显示文摘 | Uranga RM Mateos MV Giusto NM | | 0，，： | 1 |
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