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| 1 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Genetic divergence of a sym-patric lake-resident-anadromous three-spined stickleback Gasterosteusaculeatus species pair显示文摘 | Drevecky C J Falco R Aguirre W E | 2013 | Journal of Fish Biology2013，83，1： | 1 |
| 4 | Regression of primary gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma after eradication of Helicobacter pylori显示文摘 | Falco Jover G Martinez EgeaA Sanchez Cuenca J | 1999 | Rev Esp Enferm Dig1999，91，8： | 1 |
| 5 | Bounded constrained fihering for GPS/INS integration 显示文摘 | Einicke G Falco G Malos J | 2013 | IEEE Transactions on Automatic Control2013，58，1： | 1 |
| 6 | Tailoring the porosity of chemically activated hydrothermal carbons: influence of the precursor and hydrothermal carbonization temperature 显示文摘 | FALCO C MARCO-LOZAR J SALINAS-TORRES D | 2013 | Carbon2013，62，2013： | 1 |
| 7 | Sentinel lymph node: detection of micrometastases of melanoma in a molecular study 显示文摘 | Denninghoff VC Kahn AG Falco J | 2004 | Mol Diagn2004，8，： | 1 |
| 8 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | Lima F Falco V De Baima J | 2001 | Med Sci Sports Exerc2001，33，8： | 1 |
| 9 | An update of the systematic assessment of mechanical lumbar disc decompression with nucleoplasty显示文摘 | MANCHIKANI L FALCO F J BENYAMIN R M | 2013 | Pain Physician2013，16，2： | 1 |
| 10 | Percutane ous arterial embolization in the management of rectus sheath hematoma显示文摘 | RIMOLA J PERENDREU J FALCO J | 2007 | AJR Am J Roentgenol2007，188，： | 1 |
| 11 | Health risks of dietary intake of environmental pollutants by elite sportsmen and sportswomen 显示文摘 | FALCO G BOCIO B A LLOBET J M | 2005 | Food and Chemical Toxicology2005，，43： | 1 |
| 12 | Rubella infection in adult onset Still's disease显示文摘 | Escudero F J Len O Falco V | 2000 | Ann Rheum Dis2000，59，6： | 1 |
| 13 | Renewable Nitrogen-Doped Hydrothermal Carbons Derived from Microalgae显示文摘 | Falco C Sevilla M White R J | 2012 | ChemSusChem2012，5，9： | 1 |
| 14 | Human exposure to polychlorinated naphthalenes through the consumption of edible marine species 显示文摘 | Llobet J M Falco G Bocio A | 2007 | Chemosphere2007，66，6： | 1 |
| 15 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | LIMA F DE FALCO V BAIMA J | 2001 | Med Sci Sports Exerc2001，33，： | 1 |
| 16 | Transcriptionally active transposable elements in recent hybrid sugarcane显示文摘 | DE ARAUJO P G ROSSI M R JESUS E M SACCARO J R N L KAJIHARA D MASSA R DEFLIX J M DRUMMOND R D FALCO M C CHABREGAS S M ULIAN E C MENOSSI M VAN SLUYS M A | 2005 | The Plant Journal2005，44，： | 1 |
| 17 | Bounded con- strained filtering for GPS/INS integration显示文摘 | EIMCK G A FALCO G MALOS J T | 2012 | Automatic Control IEEE Transactions on2012，58，1： | 1 |
| 18 | PDC bit selection through cost prediction estimates using crossplots and sonic log data显示文摘 | MAIDLA E E DUMANS C F | 1993 | SPE/IADC 257331993，2，： | 1 |
| 19 | Concentrations of PCDD/PCDFs and PCBs in fish and seafood from the Catalan (Spain) market: estimated human intake 显示文摘 | Bocio A Domingo J L Falco G | 2007 | Environment International2007，33，2： | 1 |
| 20 | Design,synthesis and biological activity of acyl substituted 3 amino 5 methyl 1,4,5,7-tetrahydro pyrazolo pyridin-6 ones as potential hyp-notic drugs显示文摘 | Falco J L Lloveras M BuiraI | 2005 | Eur J Med Chem2005，40，： | 1 |
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