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| 1 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Depression symp-toms and hypothyroidism in a population- based study of mid-dle- aged Brazilian women 显示文摘 | GUIMARAES J M de S L BAIMA J | 2009 | J Affect Disord2009，117，12： | 1 |
| 3 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | Lima F Falco V De Baima J | 2001 | Med Sci Sports Exerc2001，33，8： | 1 |
| 4 | Hereditary corticosteroid- binding globuhn deficiency due to a missense mutation (Asp367Asn, CBG Lyon) in a Brazilian kindred 显示文摘 | Brunner E Baima J Vieira TC | 2003 | Clin Endo- crinol2003，58，6： | 1 |
| 5 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | LIMA F DE FALCO V BAIMA J | 2001 | Med Sci Sports Exerc2001，33，： | 1 |
| 6 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | Lima F De Falco V Baima J | 2001 | Mad Sci Sports Exert2001，33，8： | 1 |
| 7 | Impairment-driven cancer rehabilita- tion: an essential component of quality care and survivorship显示文摘 | Silver JK Baima J Mayer RS | 2013 | CA Cancer J Clin2013，63，5： | 1 |
| 8 | Effect of impact load and active load on bonemetabolism and body composition of adolescent athletes显示文摘 | Lima F Falco V De Baima J Carazzato JG Pereira RM | 2001 | Med Sci Sports Exerc2001，33，8： | 1 |
| 9 | Evidence for linkage between essential hypertension and a putative locus on human chromosome 17显示文摘 | Baima J Nicolaou M Schwartz F | 1999 | Hypertension1999，34，： | 1 |
| 10 | De-pression symptoms and hypothyroid ism in a population-based study of middle aged Brazilian women显示文摘 | Guimar Aes JM de Souza Lopes C Baima J | 2009 | J AffectDisord2009，117，12： | 1 |
| 11 | Depyression smptoms and hypoth- yroid ism in a Populationbased study of middle aged Brazilian women 显示文摘 | Guimar Aes JM de Souza LoPes C Baima J | 2009 | J Affect Disord2009，117，12： | 1 |
| 12 | Impairment-driven cancer rehabilita- tion: an essential component of quality care and survivorship 显示文摘 | Silver JK Baima J Mayer RS | 2013 | CA Cancer J Clin2013，63，5： | 1 |
| 13 | Impairment-driven cancer rehabilita- tion:an essential component of quality eare and survivorship 显示文摘 | Silver JK Baima J Mayer RS | 2013 | CA Cancer J Clin2013，63，5： | 1 |
| 14 | Depression symptoms and hypothyroidism in a population-based study of middle-aged Brazilian women显示文摘 | Guimaraes JM de Souza Lopes C Baima J | 2009 | J Affect Disord2009，117，12： | 1 |
| 15 | Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil显示文摘BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe disease.The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active IBD.We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD.AIM To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in Brazil.METHODS This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February 2017.The proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were examined.RESULTS The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,respectively.The most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least once.Discontinuations/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,respectively.The median time to first mild or no activity was 319(IQR:239-358)d for CD and 320(IQR:288-358)d for UC patients.At 9-12 mo,22.0%of CD and 20.0%of UC patients had active disease.CONCLUSION Although a marked proportion of active IBD patients achieved disease control within one year,the considerable time to achieve this outcome represents an unmet medical need of the current standard of care in a Brazilian real-world setting. | Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio Pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio Maria Chebli Maria de Lourdes Abreu Ferrari Julia F Campos Maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
| 16 | Liver biopsy for visceral leishmaniasis diagnosis in pregnancy: report of 2 cases显示文摘Visceral leishmaniasis(VL) or kala-azar is a zoonosis caused by intracellular protozoa of the Leishmania genus and is transmitted to humans by the bite of phlebotomine sandflies. It particularly affects cells in the phagocytic mononuclear system, accompanied by disturbances of cellular and humoral immunity. VL is potentially fatal and is characterized by fever, hepatosplenomegaly, diarrhea, epistaxis, jaundice, anemia, leucopenia, thrombocytopenia, hypoalbuminemia and hyperglobulinemia. Diagnostic suspicion is based on epidemiological, clinical and laboratory data and isconfirmed by detecting the parasite in infected tissue. Splenic aspiration is the most sensitive method, followed by bone marrow aspiration(BMA) by sternal puncture, liver biopsy and lymph node aspiration; but, due to safety concerns, BMA is the most recommended method. VL is included as a target disease by players in drug research and development. Severe liver dysfunction associated with VL is uncommon. We report two VL cases in pregnant women from Bauru, Sao Paulo state, Brazil, considered an endemic area. The first of them developed hepatic failure due to fulminant hepatitis. In both cases, BMA was unable to find the protozoan; thus, liver biopsy was the only means of making the diagnosis. | Talles Bazeia Lima Clarissa Ribeiro Villar Maria Aparecida Marchesan Rodrigues Júlio Pinheiro Baima Fábio da Silva Yamashiro Letícia Campos Franzoni Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro Lígia Yukie Sassaki | 2013 | World Journal of Clinical Infectious Diseases2013，3，2： | 0 |
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