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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 3 | What prognostic factors are important in duodenal adenocarcinoma显示文摘 | Faisal G B Michel M M Michael G S | 2000 | Arch Surg2000，135，1： | 1 |
| 4 | Antibiotic susceptibility pattern and multiple antibiotic resistances (MAR) calculation of extended spectrum 13-1actamase (ESBL) producing Escherichia coli and Klebsiella species in Pakistan 显示文摘 | Riaz S Faisal M Hasnain S | 2013 | African Journal of Biotechnology2013，10，33： | 1 |
| 5 | Changes in asphaltenes during ther- mal cracking of residual oils显示文摘 | LABABIDI HAITHAM M S SABTI HAWRAA M ALHU- MAIDAN FAISAL S | 2014 | Energy & Fuels2014，117，30： | 1 |
| 6 | A novel voltage sag source detection method using TFR technique显示文摘 | Mohamed A Shareef H Faisal M F | 2010 | Interna- tional Review of Electrical Engineering2010，5，5： | 1 |
| 7 | Risk- based maintenance (RBM): A quantitative approach for maintenance/ inspection scheduling and planning 显示文摘 | Khan Faisal I Haddara Mahmoud M | 2003 | Journal of Loss Prevention in the Process Industries2003，16，6： | 1 |
| 8 | Long term blocking of GABA-A receptor in locus coeruleus by bilateral microinfusion of picrotoxin reduced rapid eye movement sleep and increased brain Na-K ATPase activity in freely moving normally behaving rats显示文摘 | Kaur S Panchal M Faisal M | 2004 | Behav Brain Res2004，151，12： | 1 |
| 9 | PLGA-microsphere mediated clearance of bilirubin in temporarily hyperbilirubinemic rats: An alternate strategy for the treatment of experimental jaundice 显示文摘 | Ahmad N Arif K Faisal S M | 2006 | Biochimica et Biophysica Acta2006，1760，2： | 1 |
| 10 | Changes in photosynthetic activity, pigment composition, electrolyte leakage, lipid peroxidation, and antioxidant enzymes during ex vitro establishment of micropropagated Rauvolfia tetraph2lla plantlets 显示文摘 | Faisal M Anis M | 2009 | Plant Cell Tissue and Organ Culture2009，99，： | 1 |
| 11 | The impact of culture and sociological and psychological issues on muslim patients with breast cancer in Pakistan显示文摘 | Banning M Hafeez H Faisal S | 2009 | Cancer Nuts2009，32，4： | 1 |
| 12 | Interaction of Cadmium and Benzo pyrene in Mummichog (Fundulus heteroclitus):Effects on acute mortality显示文摘 | Hurk P Faisal M Roberts J M H | 1999 | Marine Environmental Research1999，46，15： | 1 |
| 13 | Identification of the molecules involved in zebra mussel (Dreissena polymorpha ) hemocytes host defense 显示文摘 | XU W FAISAL M | 2009 | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology2009，154，1： | 1 |
| 14 | Determi-nants of postoperative visual recovery in suprasellarmeningiomas显示文摘 | Galal A Faisal A Al-Werdany M | 2010 | Acta Neurochir(Wien)2010，152，1： | 1 |
| 15 | Heterogeneous photocatalytic degradation of an anthraquinone and a triphenylmethane dye derivative in aqueous suspensions of semiconductor显示文摘 | Tariq M A Faisal M Saquib M | 2008 | Dyes and Pigments2008，76，2： | 1 |
| 16 | The impact of culture and sociological and psychological issues on Muslim pa- tients with breast cancer in Pakistan显示文摘 | Banning M Hafeez H Faisal S et a/ | 2009 | Cancer Nurs2009，32，4： | 1 |
| 17 | Identification of multiple power quality disturbances using S-transform and rule based classification technique 显示文摘 | Faisal M F Mohamed A | 2009 | Journal ofAppliedSeiences2009，9，15： | 1 |
| 18 | Different techniques of transconjunctival cannulated vitrectomy versus conventional non-cannulated vitrectomy in various vitreoretinal disorders显示文摘 | Amin Faisal Ellakwa Sameh M Elgouhary Hammouda Ghoraba | 2013 | Clinical Ophthalmology (default)2013，，： | 1 |
| 19 | Unreamed femoral nailing injury显示文摘 | ABBAS D FAISAL M BUTTMS | 2000 | Int Care Injuted2000，31，： | 1 |
| 20 | Transdermal and topical delivery of anti-inflammatory agents using nanoemul- sion/microemulsion:An updated review 显示文摘 | Shakeel F Ramacan W Faisal M S | 2010 | Current Nano- science2010，6，2： | 1 |
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