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| 1 | 一氧化氮合酶基因治疗在心血管疾病中的应用显示文摘 | Alex F.Chen 缪朝玉 | 2002 | 中华心血管病杂志2002，30，2： | 4 |
| 2 | Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis显示文摘Ischemic heart diseases(IHDs)cause great morbidity and mortality worldwide,necessitating effective treatment.Salvianic acid A sodium(SAAS)is an active compound derived from the well-known herbal medicine Danshen,which has been widely used for clinical treatment of cardiovascular diseases in China.This study aimed to confirm the cardioprotective effects of SAAS in rats with myocardial infarction and to investigate the underlying molecular mechanisms based on proteome and transcriptome profiling of myocardial tissue.The results showed that SAAS effectively protected against myocardial injury and improved cardiac function.The differentially expressed proteins and genes included important structural molecules,receptors,transcription factors,and cofactors.Functional enrichment analysis indicated that SAAS participated in the regulation of actin cytoskeleton,phagosome,focal adhesion,tight junction,apoptosis,MAPK signaling,and Wnt signaling pathways,which are closely related to cardiovascular diseases.SAAS may exert its cardioprotective effect by targeting multiple pathways at both the proteome and transcriptome levels.This study has provided not only new insights into the pathogenesis of myocardial infarction but also a road map of the cardioprotective molecular mechanisms of SAAS,which may provide pharmacological evidence to aid in its clinical application. | Dan Jia Cheng-zhong Zhang Yan Qiu Xiao-fei Chen Lin Jia Alex F.Chen Yi-feng Chai Zhen-yu Zhu Jin Huang Chuan Zhang | 2019 | Acta Pharmacologica Sinica2019，40，12： | 4 |
| 3 | 量子点540诱导人皮肤成纤维细胞DNA双链断裂显示文摘目的探讨具有多聚乙烯基乙二醇(PEG)作为包被材料及无PEG包被的CdSe/ZnS(内芯/外壳)量子点540的DNA损伤特性。方法分别应用细胞毒性实验(MTS)和苔盼蓝法分析经量子点540处理后人皮肤成纤维细胞的存活率和增殖情况,γH2AX焦点形成及彗星实验探讨DNA损伤情况。结果8 nmol/L和80 nmol/L有PEG包被的量子点540处理细胞后,细胞生存率及生长趋势与阴性对照相比差异无统计学意义。而无PEG包被的量子点540在同样剂量下可引起细胞生存率及生长趋势的下降。同时,无PEG包被的量子点540可使细胞核内γH2AX焦点数量以及有γH2AX焦点的细胞数量增加,有彗尾的细胞数量增加,且尾相增大。结论量子点540在PEG的包被下无明显细胞毒性。在没有PEG包被的情况下,量子点540均表现出细胞毒性以及遗传毒性作用,可导致细胞DNA的双链断裂。 | 章晨 董正伟 沈筱筠 Frank F.Chen 杨军 | 2008 | 毒理学杂志2008，22，3： | 3 |
| 4 | 螺旋藻培养方法的初步探讨显示文摘螺旋藻(spirulina)是富含蛋白质、氨基酸和维生素等多种营养物质的新型食品,被称为‘21世纪的理想食品’。本文主要讨论螺旋藻的培养方法,尤其是光合异养条件下的培养规律,并对螺旋藻的工业化高细胞密度的培养进行了初步的探讨。 | 张义明 Steven F.Chen 郭祀远 李琳 | 1996 | 中国食品工业1996，，1： | 2 |
| 5 | Spontaneous tumour rupture and prognosis in patients with hepatocellular carcinoma显示文摘 | C.‐N.Yeh W.‐C.Lee L.‐B.Jeng M.‐F.Chen M.‐C.Yu | 2002 | Br J Surg2002，，9： | 2 |
| 6 | Safety and efficacy of two‐step peginterferon α‐2a treatment in patients of chronic hepatitis B with acute exacerbation显示文摘 | C.‐C.Chen P.‐C.Wang H.‐W.Chang C.‐F.Chen | 2012 | Journal of Viral Hepatitis2012，，3： | 1 |
| 7 | 查看详情显示文摘 | A.B.Mu(n)oz-García D.E.Bugaris M.Pavone J.P.Hodges A.Huq F.Chen H.-C.Loye and E.A.Carter | | 0，，15： | 1 |
| 8 | Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation显示文摘 | Hania A.Al‐Hallaq Loren K.Mell Julie A.Bradley Lucy F.Chen Arif N.Ali Ralph R.Weichselbaum Gillian M.Newstead Steven J.Chmura | 2008 | Cancer2008，，9： | 1 |
| 9 | STUDY ON THE TANTALIZING ON THE SURFACE OF TITANIUM ALLOY BY NET-SHAPE CATHODE GLOW DISCHARGING显示文摘A new net-shape cathode sputtering target which has a simple structure and a hig h sputtering was put forward. The multiple-structure made of alloying and coatin g layers of tantalum was achieved on the surface of TC4 (Ti6Al4V) using this met hod in double glow surface alloying process. The tantalized samples were investi gated by SEM, XRD and electrochemical corrosion method .Results show the complic ated tissue of pure tantalizing layer and diffusion layer was successfully forme d on the surface of TC4 with the method of net-shape cathode glow discharge, whi ch further improved the corrosion-resistance of TC4 and formed good corrosion-re sistant alloys. | F.Chen H.Zhou Y.F.Zhang J.D.Pan | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，3： | 1 |
| 10 | Studies on a kinetic model for butyric acid bioproduction by Clostridium butyricum显示文摘 | Q.Kong G.Q.He F.Chen H.Ruan | 2006 | Letters in Applied Microbiology2006，，1： | 1 |
| 11 | Simple water balance model for estimating runoff at different spatial and temporal scales显示文摘 | Schaake J.C V.I.Koren Q.Y.Duan K.Mitchell and F.Chen | | 0，，3： | 1 |
| 12 | Heterogeneous Investment Opportunities in Multiple-Segment Firms and the Incremental Value Relevance of Segment Accounting Data显示文摘 | Peter F.Chen Guo chang Zhang | | 0，，： | 1 |
| 13 | Solid-state alloying of Al-Mg alloys by accumulative roll-bonding:Microstructure and properties显示文摘In this study,a novel solid-state alloying approach was adopted to fabricate Al-Mg alloys with high Mg contents(C_(Mg)) by accumulative roll-bonding(ARB)of Al and Mg elemental materials to ultrahigh cycles.Experimental results showed that the degree of alloying increased with the increase of ARB cycles and a supersaturatedα-Al solid solution accompanied with nanoprecipitates was formed in the Al-Mg alloys by ARB to 70 cycles.The as-prepared Al-Mg alloys exhibited enhanced mechanical properties,with a maximum tensile strength of∼615 MPa and a tensile elongation of∼10%at C_(Mg)=13 wt.%.The high strength can be attributed to different mechanisms,namely solid solution strengthening,grain boundary strengthening,dislocation strengthening,and precipitation strengthening.The Al-Mg alloys showed increased work hardening with increasing C_(Mg),due to the enhanced formation of nanoprecipitates.Meanwhile,no obvious drop in the intergranular corrosion(IGC)resistance was found in the Al-Mg alloys with C_(Mg) up to 13 wt.%.Moreover,sensitization treatment was found to induce little decrease in the IGC resistance of the Al-Mg alloys with C_(Mg)≤13 wt.%.We found that the excellent IGC resistance was due to the suppression of grain boundary precipitation by the preferred formation of precipitates within the grains that were induced by ARB.Our study indicated the novelty of the present solid-state alloying approach to achieving a superior combination of high mechanical properties and IGC resistance in Al-Mg alloys. | X.M.Mei Q.S.Mei J.Y.Li C.L.Li L.Wan F.Chen Z.H.Chen T.Xu Y.C.Wang Y.Y.Tan | 2022 | Journal of Materials Science & Technology2022，，30： | 1 |
| 14 | 查看详情显示文摘 | F.Gao Y.Yuan K.F.Wang X.Y.Chen F.Chen J.Liu and Z.F.Ren | | 0，，： | 1 |
| 15 | 查看详情显示文摘 | F.Chen A.Xu G.Zhang Y.Li and S.Succi | | 0，，05： | 1 |
| 16 | A Modified I‐PCR to detect the factor VIII Inv22 for genetic diagnosis and prenatal diagnosis in haemophilia A显示文摘 | Z. H.HE S. F.CHEN J.CHEN W. Y.JIANG | 2012 | Haemophilia2012，，3： | 1 |
| 17 | Value Relevance of International Accounting Standards Harmonization:Evidence from A-and B-share Markets in China显示文摘 | Lin Z F.Chen | | 0，，02： | 1 |
| 18 | MicroRNA regulation of endothelial progenitor cell angiogenesis in diabetes显示文摘Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabetes that correlates inversely with its mortality rate.In addition,EPC angiogenic functions are severely impaired in diabetes.However,the molecular and cellular mechanisms underlying EPC dysfunction are poorly understood.Our current studies have focused on in vitro and in | Alex F.Chen | 2010 | 中国病理生理杂志2010，26，A10： | 1 |
| 19 | Piezoresistive Materials from Directed Shear‐Induced Assembly of Graphite Nanosheets in Polyethylene显示文摘 | J.‐R.Lu W.‐G.Weng X.‐F.Chen D.‐J.Wu C.‐L.Wu G.‐H.Chen | 2005 | Adv Funct Mater2005，，8： | 1 |
| 20 | 查看详情显示文摘 | Zeng Q Shi J Jiang G Yang M.Wang F.Chen J | | 0，，： | 1 |
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