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| 1 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 2 | T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism:implications for tubule formation显示文摘 | Mach F Schonbeck U Fabunmi R P | 1999 | Am J Pathol1999，154，1： | 1 |
| 3 | Role of the vascular endothelium in patients with angina pectoris or acute myocardial infarction with normal coronary arteries显示文摘 | Sztajzel J Mach F Righetti A | 2000 | Postgrad Med J2000，76，891： | 1 |
| 4 | Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes:a role for CD40 signaling in plaque rupture显示文摘 | Schonbeck U Mach F Sukhova G K | 1997 | Circ Res1997，81，3： | 1 |
| 5 | Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation显示文摘 | Arnaud C Mach F | 2005 | Arch Mal Coeur Vaiss2005，98，： | 1 |
| 6 | Elevation of creatine kinase in acute severe asthma in not cardiac origin 显示文摘 | Lovis C Mach F Unger PF | 2001 | Intensive Care Med2001，27，： | 1 |
| 7 | Immunosuppressive effects of statins 显示文摘 | MACH F | 2002 | At heroscler Suppl2002，3，1： | 1 |
| 8 | Insulin resist- ance: a proinflammatory state mediated by lipid-in- duced signaling dysfunction and involved in atheroscle- rotic plaque instability显示文摘 | Montecucco F Steffens S Mach F | 2008 | Mediators Inflamm2008，2008，： | 1 |
| 9 | Functional ligand is expressed on human vascular endothelial cells,and macrophages:implications for CD40-CD40 ligand signaling in atherosclerosis显示文摘 | Mach F Schonbeck U Sukhova G K | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 10 | New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor显示文摘 | Monteeucco F Mach F | 2008 | Clin Interv Aging2008，3，2： | 1 |
| 11 | Activation of monocyte / macrophage functions related to acute atheroma complication by ligation of CD40L induction of collagenase, stromelysin,and tissue factor显示文摘 | Mach F Schonbeck U Bonnefoy JY | 1997 | Circulation1997，96，2： | 1 |
| 12 | P Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-γ induced expression of the T cell active CXC chemokines IP-10,Mig and TAC in the human endothelia cells显示文摘 | Marx N Mach F Sauty A | 2005 | J Immunol2005，164，： | 1 |
| 13 | Reduction of atherosclerosis in mice by inhibition of CD40 signalling显示文摘 | SCHONBECK U SUKHOYA SK | 1998 | Nature1998，394，： | 1 |
| 14 | Ligand of CD40 activates interleukin 1beta-converting enzyme(caspase-1)activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta显示文摘 | Schinbeck U Mach F Bonnefoy JY | 1997 | J Biol Chem1997，272，19： | 1 |
| 15 | Reduction of atherosderosis in mice by inhibition of CD40 signalling显示文摘 | Mach F Schonbeck U Sukhova GK | 1998 | Nature1998，394，： | 1 |
| 16 | Role of Renin- Angiotensin system in inflammation, immunity and aging显示文摘 | Capettini LS Montecucco F Mach F | 2012 | Curt Pharm Des2012，18，7： | 1 |
| 17 | Generation of biologically active IL-1 beta by matrix metalloproteinases:a novel caspase-1-independent pathway of IL-1 beta processing显示文摘 | Schonbech U Mach F Libby P | 1998 | Immuno11998，161，7： | 1 |
| 18 | Atherosclerosis is an inflammatory disease显示文摘 | Montecucco F Mach F | 2009 | Semin Immunopathol2009，31，1： | 1 |
| 19 | DEAP-HUS:Deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome 显示文摘 | ZIPFEL P F MACHE C | 2010 | Pediatric Nephrol2010，25，： | 1 |
| 20 | Inflammation and atherosclerosis显示文摘 | Steffens S Mach F | 2004 | Herz2004，29，8： | 1 |
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