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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 3 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 4 | Software- defined networking: A comprehensive survey显示文摘 | KREUTZ D RAMOS F M V VERISSIMO P E | 2015 | Proceedings of the IEEE2015，103，1： | 1 |
| 5 | Biological nitrogenand phenol removal from saline industrial wastewater bysubmerged fixed-film reactor显示文摘 | Ramos A F Gomez M A Hontoria E | 2007 | Journal of Hazardous Materials2007，142，1： | 1 |
| 6 | Reduced- dimension blind space - time 2 - D Rank receivers for DS - CDMA communication systems 显示文摘 | CHEN Y F ZOLTOWSKI M D RAMOS J | 2000 | IEEE Trans on Signal Process2000，48，： | 1 |
| 7 | Influence of skimmed milk concentrate replacement by dry dairy products in a low fat set-type yoghurt model system显示文摘 | Guzaman-Gonzalez M Morals F Ramos M | 1999 | Journal of Science Food and Agriculture1999，，79： | 1 |
| 8 | Short and long term effects of malnutrition in rats during lactation on the body weight of offspring显示文摘 | Passos M C F Ramos C F Moura E G | 2000 | Nutrition Research2000，20，11： | 1 |
| 9 | Study of the slow batch pyrolysis of mixtures of plastics, tyres and forestry biomass wastes显示文摘 | PARADELA F PINTO F RAMOS A M | 2009 | Journal of Analytical and Applied Pyrolysis2009，85，12： | 1 |
| 10 | Effect of Some Compatibilizing Agents on Clay Dispersion of Polypropylene-clay Nanocomposites 显示文摘 | Lopez-Quintanilla M L Sanchez-Valdes S Ramos de Valles L F | 2006 | J Appl Polym Sei2006，100，： | 1 |
| 11 | Congenital renal arteriovenous malformation:the value of magnetic resonance imaging for dignosis and intravascular management显示文摘 | Miranda-Utrera N Pamplona -Casamayor M Guerrero -Ramos F | 2010 | Actas Urol Esp2010，34，2： | 1 |
| 12 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 13 | Leptin serum concentration, food intake and body weight in rats whose mothers were exposed to malnutrition during lactation 显示文摘 | Teixeira C V Passos M C F Ramos C D F | 2002 | The Journal of Nutritional Biochemistry2002，13，： | 1 |
| 14 | Generalized extremal optimization for solving complex optimal design problems显示文摘 | Sousa F L Vlassov V Ramos F M | 2003 | Lecture Notes in Computer Science2003，2723，6： | 1 |
| 15 | Production of an Extracellular Polysaccharide with Emulsifier Properties by Penicillium citrinum 显示文摘 | CAMARGO-DE-MORAIS M M RAMOS S A F PIMENTEL M C B | 2003 | World J Microbiol &Biotechnol2003，19，2： | 1 |
| 16 | Computational analysis of ligand recognition sites of homo-and heteropentameric5-HT3 receptors显示文摘 | Moura Barbosa A J De Rienzo F Ramos M J | 2010 | Eur J Med Chem2010，45，11： | 1 |
| 17 | Heart-lung interactions with different ventilatory settings during acute lung in- jury and hypovolaemia: an experimental study显示文摘 | da Silva Ramos F J de Oliveira E M Park M | 2011 | Br J Anaesth2011，106，3： | 1 |
| 18 | Optimization of operational planning for wind/hydro hybrid water supply systems显示文摘 | VIEIRA F RAMOS H M | 2009 | Renewable Energy2009，34，3： | 1 |
| 19 | Effect of some compatibilizing agents on clay dispersion of polypropyleneclay nanocomposites 显示文摘 | Lopez-Quintanilla M L Sanchez-Valdes S Ramos de Valle L F | 2006 | Journal of Applied Polymer Science2006，100，6： | 1 |
| 20 | Effect of Some Compatibilizing Agents on Clay Dispersion of Polypropylene-Clay Nanocomposites显示文摘 | Lopez-Quintanilla M L Sanchez V S Ramos de Valle L F | | Journal of Applied Polymer Science0，100，： | 1 |
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