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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 3 | Modeling cortical cataractogenesis XX:In vitro effect of α-lipoic acid on glutathione concentration in lens in model diabetic cataractogenesis显示文摘 | Kilic F Handelman GJ Traber K Tsang K Packer L Trerithick JR | 1998 | Biochem Molec Bio Int1998，46，3： | 1 |
| 4 | Code validation for high-speed flow simulation over satellite launch vehicle 显示文摘 | Azevedo J L F Moraes P Jr | 1996 | Journal of Spacecraft and Rockets1996，30，1： | 1 |
| 5 | 查看详情显示文摘 | Hof F Craig S L Nuckolls C Rebek J Jr | | 0，，： | 1 |
| 6 | Application of face-gear drives in helicopter transmissions显示文摘 | Litvin L F Wang J C Bossler R B Jr | 1994 | Journal of Mechanical Design1994，116，3： | 1 |
| 7 | A simple reversed phase high-performance liquid chromatography method polysorbate 80 quantitation in monoclonal antibody drug products显示文摘 | ADAMO M DICK L W Jr QIU D F | 2010 | J Chromatogr B Analyt Technol Biomed Life Sci2010，878，21： | 1 |
| 8 | Isolation system for vibration control of stay cables显示文摘 | Inho H Jong S L Jr Spencer B F | 2009 | Journal of Engineering Mechanics2009，135，1： | 1 |
| 9 | The molecular structure of green fluorescent protein 显示文摘 | Yang F Moss L G Phillips G N Jr | 1996 | Nat Biotechnol1996，14，10： | 1 |
| 10 | Soil microbial biomass and selected soil enzyme activities effect of fertilization and cropping practices显示文摘 | Bolton H Jr Elliott L F Papendick R I | 1985 | Soil Bio Biochem1985，17，3： | 1 |
| 11 | Hypoxia induces cyclooxygenase-2 via the NF-kappa Bp65 transcription factor in human vascular endothelial cells 显示文摘 | SCHMEDTJE J F Jr JI Y S LIU W L | 1997 | J Biol Chem1997，272，1： | 1 |
| 12 | Crystal structure of bovine coronavirus spike pro- tein lectin domain 显示文摘 | Peng G Xu L Lin YL Chen L Pasquarella JR Holmes KV Li F | 2012 | J Biol Chem2012，287，41： | 1 |
| 13 | Dynamic model- ing of a dual clearance squeeze film damper:Part I test rigand dynamic model with one damper显示文摘 | Moraru L Keith T G Jr Dimofte F | 2003 | Tribology Trans- actions2003，46，2： | 1 |
| 14 | Methane emissions from rice paddies: a process study summary 显示文摘 | Sass R L Fisher F M Jr | 1997 | Nutrient Cycling in Agroecosystems1997，49，13： | 1 |
| 15 | Response of coastal fishes to the Gulf of Mexico oil disaster显示文摘 | Fodrie F J Heck Jr K L | 2011 | PloS one2011，6，21： | 1 |
| 16 | Phase behavior of CO2 and crude oil in low-temperature reservoirs显示文摘 | Orr F M Jr Yu A D Lien C L | 1981 | SPE Journal1981，21，4： | 1 |
| 17 | Advances in GML for geospatial applications显示文摘 | Lu C T Dos Santos Jr R F Sripada L N | 2007 | Journal of Computer Applications Geoinformatica2007，11，： | 1 |
| 18 | Bayesian statistical analysis of protein sidechain rotamer preferences显示文摘 | Dunbrack R L Jr Cohen F E | 1997 | Protein Sci1997，6，8： | 1 |
| 19 | Numerical method for convection-dominated diffusion problem based on combining the method of characteistics with finite element of finite difference procedures显示文摘 | DOUGLAS L JR RUSSELL T F | 1982 | SIAM J Numer Anal1982，19，5： | 1 |
| 20 | Two families of mixed finite elements for second order elliptic problems显示文摘 | F Breezi J Douglas Jr L D Marini | 1985 | Numer Math1985，47，： | 1 |
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