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| 1 | Biomarkers in schizophrenia:A focus on blood based diagnostics and theranostics显示文摘Identifying biomarkers that can be used as diagnostics or predictors of treatment response(theranostics) in people with schizophrenia(Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include:(1) brain-derived neurotrophic factor;(2) inflammation and immune function;(3) neurochemistry;(4) oxidative stress response and metabolism;(5) epigenetics and micro RNA; and(6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, bloodoriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development. | Chi-Yu Lai Elizabeth Scarr Madhara Udawela Ian Everall Wei J Chen Brian Dean | 2016 | World Journal of Psychiatry2016，6，1： | 6 |
| 2 | The use of barley-straw to control general and blue-green algal growth in a derbyshire reservoir显示文摘 | EVERALL N C LEES D R | 1996 | Water Research1996，30，2： | 1 |
| 3 | The use of barley-straw to control general and blue-green algal growth in a Derbyshire reservoir显示文摘 | EVERALL N C LESS D R | 1996 | Water Research1996，30，2： | 1 |
| 4 | Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy 显示文摘 | EVERALL I VAIDA F KHANLOU N | 2009 | J Neurovirol2009，15，56： | 1 |
| 5 | The use of barley-straw to control general and blue-green algal growth in a derbyshire reservoir 显示文摘 | Everall N C Lees D R | 1996 | Water Research1996，30，2： | 1 |
| 6 | The identification and significance of chemicals released from decomposing barley straw during reservoir algal control显示文摘 | EVERALL N C LEES D R | 1997 | Water Research1997，31，3： | 1 |
| 7 | The identification and significance of chemicals released from decomposing barley straw during reservoir algal control显示文摘 | EVERALL N C LEES D R | 1997 | Water Research1997，31，3： | 1 |
| 8 | Two-dimensional as- sessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder 显示文摘 | Beasley CL Honavar M Everall IP | 2009 | Schizophr Res2009，115，23： | 1 |
| 9 | Food-poisoning due to staphylococcal enterotoxin E 显示文摘 | Morris CA Conway HD Everall PH | 1972 | Lancet1972，2，7791： | 1 |
| 10 | Modeling and measuring the effect of refraction on the depth resolution of confocal raman microscopy显示文摘 | EVERALL N J | 2000 | Appl Spectrosc2000，54，6： | 1 |
| 11 | The identification and significance of chemicals released from decomposing barley straw dur- ing reservoir algal control 显示文摘 | Everall N C Lees D R | 1997 | Water Res1997，31，3： | 1 |
| 12 | Creating a future: A study of resilience in suicidal female adolescents 显示文摘 | Everall R D Altrows K J Paulson B L | 2006 | Journal of Counseling & Development2006，，4： | 1 |
| 13 | Food-poisoning due to staphylococcal enterotoxin E显示文摘 | MORRIS C A CONWAY H D EVERALL P H | | Lancet0，300，： | 1 |
| 14 | Diminished somatostatin gene expression in individuals with HIV and major depressive disorder显示文摘 | Everall P Salaria S Atkinson J H | 2006 | HNRC Neurology2006，67，： | 1 |
| 15 | Confocal raman microscopy: why the depth resolution and spatial accuracy can be much worse than you think显示文摘 | EVERALL N J | 2000 | Appl Spectrosc2000，54，10： | 1 |
| 16 | Interaction of TiO2 Nano-Particles with Organic UV Absorbers显示文摘 | Egerton T Everall N Mattinson J | 2008 | Journal of Photochemistry & Photobiology A:Chemistry2008，193，1： | 1 |
| 17 | Depth profiling with confoeal raman microscopy显示文摘 | EVERALL N J | 2004 | Part I Spectrosc2004，19，10： | 1 |
| 18 | Neurologic complications of HIV disease and their treatment显示文摘 | Letendre SL Ellis RJ Everall I | 2009 | Top H1V Med2009，17，2： | 1 |
| 19 | The identification and significance of chemical released from decomposing barley straw during reservoir algal control显示文摘 | EVERALL N C LESS D R | 1997 | Water Research1997，31，3： | 1 |
| 20 | An electron microscopic study of basal melanocytes and high level clear cells(Langerhans cells) in vitiligo显示文摘 | Birbeck MS Breathnach AS Everall JD | 1961 | J Invest Dermatol1961，37，1： | 1 |
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