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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Can oil prices help estimate commodity futures prices? The cases of copper and silver显示文摘 | Gonzalo Cortazar Francisco Eterovic | 2010 | Resources Policy2010，，4： | 2 |
| 3 | On the Treatment of Inequality Constraints Arising from Contact Conditions in Finite Element Analysis 显示文摘 | Eterovic A L Bathe K J | 1991 | Com- puters and Structures1991，40，2： | 1 |
| 4 | Immunoprophylatic Intraresical Application of Bacillus Calmette - Gueirin after Transuretural Resection of Superficial Bladlder Cancer 显示文摘 | Davor L SitummA Eterovic D | 2003 | Croat Med J2003，44，： | 1 |
| 5 | On the treatment of inequality constraints arising from contact conditions in finite element analysis 显示文摘 | Eterovic A Bathe K J | 1991 | Computers and Structures1991，40，2： | 1 |
| 6 | Symptom presentation of acute myocardial infarction:influence of sex, age, and risk factors显示文摘 | Culic V Eterovic D Miric D | 2002 | Am Heart J2002，144，： | 1 |
| 7 | Correlation between symptomatology and site of acute myocardial infarction显示文摘 | Culic' V Miric' D Eterovic' D | 2001 | Int J Cardiol2001，77，23： | 1 |
| 8 | On the treatment ofinequality constraints arising from contact conditions infinite element analysis显示文摘 | ETEROVIC A BATHE K J | 1991 | Computers and Structures1991，40，2： | 1 |
| 9 | Epileptic patient compliancewith prescribed medical treatment 显示文摘 | Lusid I Titlid M Eterovic D | 2005 | Acta Med Croatica2005，59，1： | 1 |
| 10 | Planning of 131I therapy for graves disease based on the radiation dose to thy- roid follicular cells显示文摘 | Eterovic D Antunovie Z Markovic V | 2008 | J Nucl Med2008，49，12： | 1 |
| 11 | Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy 显示文摘 | Lueio -Eterovic AK Piao Y de Groot JF | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 12 | Symptom presentation of acute myocardial infarction:Influence of sex,age,and risk factors显示文摘 | Culic V Eterovic D Miric D | 2002 | Am Heart J2002，144，： | 1 |
| 13 | Immunoprophylatic Intraresical Application of Bacillus Calmette-Guérin after Transuretural Resection of Superficial Bladlder Cancer显示文摘 | Davor L Situmm A Eterovic D | 2003 | Croat Med J2003，44，： | 1 |
| 14 | Planning of 131Itherapy for graves disease based on the radiation dose to thyroidfollicular cells显示文摘 | Eterovic D Antunovic Z Markovic V | 2008 | J Nucl Med2008，49，12： | 1 |
| 15 | Thyroid echogenicity pre-dicts outcome of radioiodine therapy in patients withGraves disease显示文摘 | Markovic V Eterovic D | 2007 | J Clin Endocrin Metab2007，92，9： | 1 |
| 16 | Quantitative PCR analysis of the expression profile of gene related to multiple drug resistance in tumors of the central nervous system显示文摘 | Valera ET Lucio Eterovic AKB Neder L | 2007 | J Neurooncol2007，85，1： | 1 |
| 17 | Differentia/ expression of 12 bistone deacetylase (HDAC) genes in astrocytomas and normal Daniela Buglio显示文摘 | Lucio Eterovic AK Cortez MA Valera ET | 2008 | BMC Cancer2008，8，： | 1 |
| 18 | Immunoprophylalic intraresieal application of bacillus Calmette-Gurin after transurethral resection of superficial bladder cancer显示文摘 | Davor L Situmm A Eterovic D | 2003 | Croat Med J2003，44，2： | 1 |
| 19 | Can oil prices help esti- mate commodity futures prices? The cases of copper and silver 显示文摘 | Gonzalo Cortazar Francisco Eterovic | 2010 | Resources Policy2010，，35： | 1 |
| 20 | On the treatment of inequality constraints a- rising from contact conditions in finite element analysis显示文摘 | Eterovic A Bathe K J | 1991 | Comput- ers and Structures1991，40，2： | 1 |
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