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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Pituitary adenylate cyclase-acti- vating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice 显示文摘 | Markovics A Kormos V Gaszner B | 2012 | Neurobiology of Disease2012，45，： | 1 |
| 3 | Massive sul- fide deposits discovered at 14°45rN, Mid-Atlantic Ridge显示文摘 | Batuev B N Krotov A G Markov V F | 1994 | British Ridge Newsletter1994，6，： | 1 |
| 4 | Synthesis of reversible logic circuits 显示文摘 | Shende V V Prasad A K Markov I L | 2003 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2003，22，6： | 1 |
| 5 | Production of nitride and carbonitride powders from inorganic azides by self-propagating high-temperature synthesis显示文摘 | Amosov A P Bichurov G V Markov Y M | 1997 | Refractories and Industrial Ceramics1997，38，11： | 1 |
| 6 | Massive sulfide deposits discovered at 14° 45' N, Mid Atlantic Ridge 显示文摘 | Batuev B N Krotov A G Markov V F | 1994 | British Ridge Newsletter1994，6，： | 1 |
| 7 | Ultrasound screaning for Down syndrome and other chromosomal abnormalities by fetal nuchal translucency measarement between 11 - 14 weeks of gestation 显示文摘 | Dimitrova V Markov D Chernev T | 2005 | Akush Ginekol (sofiia)2005，44，1： | 1 |
| 8 | Propagation of blast waves in a combustible gas显示文摘 | Korobeinikov V P Levin V A Markov V V | 1972 | Astronautica Acta1972，17，45： | 1 |
| 9 | Ultrasound screening for Down syndrome and other chromosomal abnormalities by fetal nuchal translucency measurement between 11-14 weeks of gestation显示文摘 | Dimitrova V Markov D Chernev T | 2005 | Akush Ginekol(Sofiia)2005，44，1： | 1 |
| 10 | Inelastic strain relaxation in the Ge quantum dot array显示文摘 | Talochkin A B Markov V A Mashanov V I | 2007 | Applied Physics Letters2007，91，9： | 1 |
| 11 | New effective method for analysis of the component composition of enzyme complexes from Trichoderma reesei显示文摘 | Markov A V Gusakov A V Kondratyeva E G | 2005 | Biochemistry (Moscow)2005，70，6： | 1 |
| 12 | Surface hydro-phobic amino acid residues in cellulase molecules as a structural fac-tor responsible for their high denim-washing performance显示文摘 | GUSAKOV A V SINITSYN A P MARKOV A V | 2000 | Enzymeand Microbial Technology2000，27，9： | 1 |
| 13 | Fixing design errors with counterexamples and resynthesis 显示文摘 | Chang K H Markov I L Bertacco V | 2008 | IEEE Transaction on CAD2008，27，1： | 1 |
| 14 | Pressure Broadening of the Rotational Line of Oxygen at 425 GHz显示文摘 | Krupnov A F Golubiatnikov G Y Markov V N | | 0，，02： | 1 |
| 15 | Asquare-root-free matrix decomposition method for energy- efficient least square computation on embedded systems 显示文摘 | Zhang C X Liu L Xu W Y Owall V Markovic D | 2014 | IEEE Embedded Systems Letters2014，6，4： | 1 |
| 16 | Nonpolar GaN Grown on Si by Hydride Vapor Phase Epitaxy Using Anodized Al Nanomask显示文摘 | Polyakov A Y Markov A V Mezhennyi M V | 2009 | Appl Phys Lett2009，94，02： | 1 |
| 17 | Synthesis of reversible logic circuits 显示文摘 | Shende V V Prasad A K Markov I L | 2003 | IEEE Trans on Circuits and Systems-I2003，22，6： | 1 |
| 18 | Occupational Exposures to Blood and Body Fluids among Health Care Workers at University Hospitals显示文摘 | v Ljiljana MarkoviC - DeniC Milos BrankoviC Na- tas a MaksimoviC | 2013 | Srp Arh Ce- lok Lek2013，141，1112： | 1 |
| 19 | Synthesis of reversi- ble logic circuits 显示文摘 | Shende V V Prasad A K Markov I L | 2003 | IEEE Trans on Circuits and Systems I2003，22，6： | 1 |
| 20 | Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid detivatives显示文摘 | LOGASHENKO E B SALOMATINA O V MARKOV A V | 2011 | ChemBioChem2011，12，5： | 1 |
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