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| 1 | Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats显示文摘AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) injury.METHODS:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,i.p.given 15 min prior to gastric ischemia) were recruited.Gastric injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 min.Gastric tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and Ang-2.Vascular endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue homogenate.To assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and immunostained.Another set of experiments was run to study vascular permeability of the stomach using Evan's blue dye.RESULTS:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P < 0.05),VEGF(36.87 ± 2.71 pg/100 mg protein vs 48.4 ± 6.53 pg/100 mg protein,P < 0.05) and MCP-1 tissue level(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced congestion.Ang-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated animals.The administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were seen.CONCLUSION:AGM protects the stomach against I/R injury by reducing vascular permeability and inflammation.This protection is possibly mediated by Akt/PI3K. | Abeer A Al Masri Eman El Eter | 2012 | World Journal of Gastroenterology2012，18，18： | 4 |
| 2 | Alexithymia and Emotional Distress in Patients With Central Serous Chorioretinopathy显示文摘 | Rupert Conrad Nina Friederike Weber Matthias Lehnert Frank Gerhard Holz Reinhard Liedtke Nicole Eter | 2011 | Psychosomatics2011，，6： | 2 |
| 3 | Acute changes in neuromuscular excitability after exhaustive whole body vibration exercise as compared to exhaustion by squatting exercise显示文摘 | JORN RITTWEGER MARCUS MUTSCHELKNAUSS DI- ETER FELSENBERG | 2003 | Clin Physiol Func Imaging2003，23，： | 1 |
| 4 | The endocrinology of growth in carp and related species显示文摘 | ETER R E MARCHANT T A | 1995 | Aquaculture1995，129，14： | 1 |
| 5 | Citric and lactic acids as root canal irrigants in vitro显示文摘 | Eters OA Barbakow F | 2000 | J Endod2000，26，1： | 1 |
| 6 | In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat 显示文摘 | E1 Eter E A1 Tuwailiri A Hagar H | 2007 | J Gastroenterol Hepatol2007，22，11： | 1 |
| 7 | Safety and efficacy of a flexi-ble dosing regimen of ranibizumab in neovascular age-relatedmacular degeneration:the SUSTAIN study 显示文摘 | Holz FG Meyer C Eter N | 2011 | Ophthalmology2011，118，4： | 1 |
| 8 | Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis显示文摘 | Scott HM Chambers HF | 2001 | PNAS2001，98，14： | 1 |
| 9 | DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture显示文摘 | Eter N Spitznas M | 2002 | Br J Ophthalmol2002，86，11： | 1 |
| 10 | External beam radiotherapy for age-related macular degeneration causes transient objective changes in tear- film function显示文摘 | Eter N Schtiller H | 2001 | Graefes Arch Clin Exp Ophthalmol2001，239，： | 1 |
| 11 | FI8-PDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis 显示文摘 | HASLERUD T BRAUCKHOFF K REIS/ETER L | 2016 | Aeta Radiol2016，57，10： | 1 |
| 12 | A new technique for tear Film fluorophotometry显示文摘 | Eter N Gobbels M | 2002 | Br J Oph thalmol2002，86，6： | 1 |
| 13 | Social force model for pedestrian dynamics显示文摘 | Dirk Helbing P'eter Moln'ar | 1995 | Phys Rev E1995，51，5： | 1 |
| 14 | Radiotherapy for age-related macular degeneration:is there a benefit for classic C NV?显示文摘 | Eter N Schüller H Spitznas M | 2001 | Int Ophthalmol2001，24，： | 1 |
| 15 | Inhibition of proinflammatory cytokines by SCH79797, a selective protease - activated receptor 1 antagonist, protects rat kidney against ischemia- reperfusion injury显示文摘 | E1 Eter EA Aldrees A | 2012 | Shock2012，37，6： | 1 |
| 16 | Nuclear factor-kappaB inhibition by pyrrolidinedithiocarbamate attenuates gastric ischemia-reperfusion injury in rats显示文摘 | El Eter E Hagar HH Al-Tuwaijiri A | 2005 | Can J Physiol Pharmaeol2005，83，6： | 1 |
| 17 | Meyer CH Intraoeular pharmacokinetics of bevacizumab after a single intravitreal injection in humans 显示文摘 | Krohne TU Eter N Holz FG | 2008 | Am J Ophthalmol2008，146，： | 1 |
| 18 | The effect of Euryale ferox (makhana),an herb of aquatic origin,on myocardial ischemicreperfusion injury显示文摘 | Samarjit D Eter D Utpal R | 2006 | Molecular and Cellular Biochemistry2006，289，： | 1 |
| 19 | Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration显示文摘 | Akim K Nicholas MS Eter JS | | 0，，： | 1 |
| 20 | Mind the gap: Societal limits to public library ef- fectiveness 显示文摘 | Glorieux Ignace Kuppens Toon and Vandebroeck Di- eter | 2007 | Library & Information Science Research2007，29，2： | 1 |
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