|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of stem cells in repair of liver injury:Experimental and clinical benefit of transferred stem cells on liver failure显示文摘Although the liver has a high regenerative capacity,as a result of massive hepatocyte death,liver failure occurs. In addition to liver failure,for acute,chronic and hereditary diseases of the liver,cell transplantation therapies can stimulate regeneration or at least ensure sufficient function until liver transplantation can be performed. The lack of donor organs and the risks of rejection have prompted extensive experimental and clinical research in the field of cellular transplantation. Transplantation of cell lineages involved in liver regeneration,including mature hepatocytes,fetal hepatocytes,fetal liver progenitor cells,fetal stem cells,hepatic progenitor cells,hepatic stem cells,mesenchymal stem cells,hematopoietic stem cells,and peripheral blood and umbilical cord blood stem cells,have been found to be beneficial in the treatment of liver failure.In this article,the results of experimental and clinical cell transplantation trials for liver failure are reviewed,with an emphasis on regeneration. | Mukaddes Esrefoglu | 2013 | World Journal of Gastroenterology2013，19，40： | 14 |
| 2 | Experimental and clinical evidence of antioxidant therapy in acute pancreatitis显示文摘Oxidative stress has been shown to play an important role in the pathogenesis of acute pancreatitis (AP). Antioxidants, alone or in combination with conventional therapy, should improve oxidative-stress-induced organ damage and therefore accelerate the rate of recovery. In recent years, substantial amounts of data about the efficiency of antioxidants against oxidative damage have been obtained from experiments with rodents. Some of these antioxidants have been found beneficial in the treatment of AP in humans; however, at present there is insufficient clinical data to support the benefits of antioxidants, alone or in combination with conven-tional therapy, in the management of AP in humans. Conflicting results obtained from experimental animals and humans may represent distinct pathophysiological mechanisms mediating tissue injury in different species. Further detailed studies should be done to clarify the exact mechanisms of tissue injury in human AP. Herein I tried to review the existing experimental and clinical studies on AP in order to determine the efficiency of antioxidants. The use of antioxidant enriched nutrition is a potential direction of clinical research in AP given the lack of clues about the efficiency and safety of antioxidant usage in patients with AP. | Mukaddes Esrefoglu | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 4 | Adrenomed ullin reduces antioxidant defense system and enhances kid- ney tissue damage in cadmium and lead exposed rats 显示文摘 | Yurekli M Esrefoglu M Ilker Dogru M | 2009 | Environmental Toxicology2009，24，3： | 1 |
| 5 | Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats显示文摘 | Taslidere E Esrefoglu M Elbe H | 2014 | Exp Lung Res2014，40，2： | 1 |
| 6 | Ultrastructural clues for the protective effect of ascorbic acid and n-acetylcysteine against oxidative damage on caerulein-induced pancreatitis显示文摘 | Esrefoglu M Gul M Ates B | 2006 | Pancreatology2006，6，5： | 1 |
| 7 | Adrenomedullin fails to reduce cadmium induced oxidative damage in rat liver显示文摘 | ESREFOGLU M GU L M DOGRU M I | 2007 | Exp Toxicol Pathol2007，58，5： | 1 |
| 8 | Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats显示文摘 | Yurekli M Esrefoglu M Dogru MI | 2009 | Environ Toxicol2009，24，3： | 1 |
| 9 | Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis显示文摘 | Esrefoglu M | 2012 | Hepat Mon2012，12，3： | 1 |
| 10 | Serum interleukin-2,interleukin-6,tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet's disease显示文摘 | Akdeniz N Esrefoglu M Keles MS | 2004 | Ann Acad Med Singapore2004，33，： | 1 |
| 11 | Ultrastructural findings and tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression in psoriasis patients before and after oral cyclosporin A therapy显示文摘 | Esrefoglu M Gul M Seyhan M | 2006 | Ultrastruct Pathol2006，30，1： | 1 |
| 12 | Amelioration of streptozotocin-induced diabetic nephropathy by melatonin,quercetin,and resveratrol in rats显示文摘 | ELBE H VARDI N ESREFOGLU M | 2015 | Human&Experimental Toxicology2015，34，1： | 1 |
| 13 | Oxidative stress and benefits of antioxidant a- gents in acute and chronic hepatitis显示文摘 | Esrefoglu M | 2012 | Hepat Mon2012，12，3： | 1 |
| 14 | Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats显示文摘 | TASLIDERE E ESREFOGLU M ELBE H | 2014 | Exp Lung Res2014，40，2： | 1 |
| 15 | Ultrastructural findings and tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression in psoriasis patients before and after oral cyclosporin A therapy显示文摘 | Esrefoglu M Gul M | 2006 | Ultrastruct Pathol2006，30，1： | 1 |
| 16 | Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination 显示文摘 | Esrefoglu M Ara C | 2010 | Ultrastrnctural Pathology2010，34，5： | 1 |
| 17 | Melatonin and CAPE arc able to prevent the liver from oxidative damage in rats: an ultra- structural and biochemical study 显示文摘 | Esrefoglu M Iraz M Ares B | 2012 | Uhrastructural Pathology2012，36，3： | 1 |
| 18 | The Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Rats显示文摘 | Sacid Coban Fahrettin Yildiz Alpaslan Terzi Behcet Al Dincer Ozgor Cengiz Ara Alaattin Polat Mukaddes Esrefoglu | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 19 | Effects ofmel- atonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in rats显示文摘 | Esrefoglu M Gul M Parlakpinar H | 2005 | Fund Clin Pharmacol2005，19，3： | 1 |
| 20 | The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis显示文摘 | Karincaoglu Y Batcioglu K Erdem T Esrefoglu M Genc M | 2005 | J Oral Pathol Med2005，34，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员