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| 1 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 2 | Accelerated degradation tests:Modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu C J | 1998 | Technometrics1998，40，： | 1 |
| 3 | Accelerated degradation tests:modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu J C | 1998 | Technometrics1998，40，2： | 1 |
| 4 | Synthesis, characterization and catalytic behaviour of SAPO-11 obtained at low crystallization times and with low organic agent content显示文摘 | LOPEZ C M ESCOBAR V ARCOS M E NOBREGA L D YANEZ F GARACIA L V | 2008 | Catalysis Today2008，，： | 1 |
| 5 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 6 | Increased prevalence of gestational diabetes mellitus among women with diagnosed polycystic ovary syndrome: A population-based study 显示文摘 | Lo J C Feigenbaum S L Escobar G J | 2006 | Diabetes Care2006，29，： | 1 |
| 7 | Identification of suitable Copulas for bivariate frequency analysis of flood peak and flood volume data显示文摘 | Chowdhary H Escobar L A Singh V P | 2011 | Hydrology Research2011，42，23： | 1 |
| 8 | Improving the Oxidation Resistance of A1CrN Coatings by Tailoring Chromium Out-Diffusion显示文摘 | Escobar Galindo R Endrino J L Martinez R | 2010 | Spectrochimica Acta Part2010，1365，11： | 1 |
| 9 | Recovery of placer gold using the Knelson Concentrator显示文摘 | MEZA L A HARTMANN W ESCOBAR C A | 1994 | Innovations in Mineral Processing1994，，1： | 1 |
| 10 | Matrix metalloproteinase-9genedeletion facilitates angio genes is after myocardial infarction显示文摘 | Lindscy M L Escobar G P Dobrucki L W | 2006 | American journal of physiology2006，290，1： | 1 |
| 11 | Using accelerated lifetests results to predict product field reliability 显示文摘 | Meeker W Q Escobar L A Hong Y L | 2009 | Technomet-rics2009，51，2： | 1 |
| 12 | Accelerated degradation tests: Modeling and analysis显示文摘 | MEEKER W Q ESCOBAR L A LU J C | 1998 | Technometrics1998，40，2： | 1 |
| 13 | Analyses of genetic diversity in Cuban rice varieties using isozyme, RAPD and AFLP markers显示文摘 | Fuentes J L Escobar F Alvarez A | 1999 | Euphytica1999，109，： | 1 |
| 14 | Risk factors for non communicable diseases:methods and global results of the CARMEN program basal survey显示文摘 | Jadue L Vega J Escobar MC | 1999 | Rev Med Chil1999，127，8： | 1 |
| 15 | Zincpretreatment prevents hepatic stellate cells fromcadmium-produced oxidative damage 显示文摘 | Souza V Escobar Mdel C Bucio L | 2004 | Cell BiolToxicol2004，20，4： | 1 |
| 16 | Experimental design for a class of accelerated degradation tests显示文摘 | BOULANGER M ESCOBAR L A | 1994 | Technometrics1994，36，3： | 1 |
| 17 | Anterior capsule opacification: A histopathological study comparing different IOL styles 显示文摘 | Wemer L Pandey SK Escobar - Gomez M | 2000 | Ophthalmology2000，107，3： | 1 |
| 18 | Pharmacological management of acutely agitated schizophrenic patients 显示文摘 | San L Arranz B Escobar R | 2005 | Curr Pharm Des2005，11，19： | 1 |
| 19 | Accelerated Degradation Tests: Modeling and Analysis显示文摘 | MEEKER W Q ESCOBAR L A LU C J | 1998 | Techno- metrics1998，40，2： | 1 |
| 20 | Pharmacological mana- gement of acutely agitated schizophrenic patients 显示文摘 | SAN L ARRANZ B ESCOBAR R | 2005 | Curr Pharm Des2005，11，19： | 1 |
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