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| 1 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 2 | Analysis and Design of Direct Power Control (DPC) for a Three Phase Synchronous Rectifier via Output Regulation Subspaces显示文摘 | Gerardo Escobar Aleksandar M Stankovic Carraso Juan M | 2003 | IEEE Trans on Power Electronics2003，18，3： | 1 |
| 3 | An adaptive controller in stationary reference frame for DSTATCOM in unbalanced operation显示文摘 | Gerardo Escobar Aleksandar M Stanlcovic Paolo Mattavelli | 2004 | IEEE Trans on Industrial Electronics2004，51，2： | 1 |
| 4 | Analysis and Validation for an Inverter-side Current Controller in LCL Grid-connected Power Systems显示文摘Transformerless grid-connected inverters offer greater efficiencies when transferring power from renewable energy sources to the electrical grid.If the grid-inverter connection is done with an LCL filter,high attenuation of switching harmonics is achieved while preserving a small-size output filter.However,damping must be included in the controller to assure closed-loop stability.This paper proposes a reference computation methodology for the inverter-side current feedback in a photovoltaic(PV)generation system connected to the grid through an LCL filter.Theoretical analysis of the closed-loop system stability and of the steady-state performance are presented as well as experimental validation of the closed-loop performance.The feedback controller includes active damping and relies on a resonant control structure which improves the ability of dealing with grid harmonic distortion.The controller uses a reduced set of measurements,which requires the inverter-side current and grid voltage only,and assures a power factor close to unity. | Jose MSosa Panfilo R.Martinez-Rodriguez Gerardo Escobar Gerardo Vazquez Andres A.Valdez-Fernandez Juan F.Martinez-Garcia | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，2： | 1 |
| 5 | Analysis and design of direct power control (DPC) for a three-phase synchronous rectifier via output regulation subspaces显示文摘 | Gerardo Escobar Aleksandar M Stankovic Juan M Carraso | 2003 | IEEE Trans on Power Electronics2003，18，3： | 1 |
| 6 | Direct torque control of induction motors: stability analysis and performance improvement显示文摘 | Romeo Ortega Nikita Barabanov Gerardo Escobar Valderrama | 2001 | IEEE AC2001，46，8： | 1 |
| 7 | Direct torque control of induction motors: stability analysis and performance improvement显示文摘 | Nikita Barabanov Gerardo Escobar Valderrama | 2001 | IEEE transactions on automatic control2001，46，8： | 1 |
| 8 | Analysis and design of direct power control (DPC) for a three phase synchronous rectifier via output regulation subspaces显示文摘 | Gerardo Escobar Aleksandar M | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
| 9 | A Hamiltonian Viewpoint in the Modeling of Switching Power Converters显示文摘 | GERARDO Escobar ARJAN J vander Schaft ROMEO Ortega | 1999 | Automatica1999，35，3： | 1 |
| 10 | A hamiltonian viewpoint in the modeling of switching power converters显示文摘 | Gerardo Escobar Arian J van der Schaft Romeo Ortega | 1999 | Automatica1999，35，3： | 1 |
| 11 | Dissipativity-base Adaptive and Robust Control of UPS in Unbalanced Operation显示文摘 | Gerardo Escobar Valderrama Aleksandar M Stankovic Paolo Mattavelli | 2003 | IEEE Transaction on Power Electronics2003，18，4： | 1 |
| 12 | Interconnection and damping assignment passivity-based control of port-controlled Hamiltonian systems显示文摘 | Romeo Ortega Arjan van der Schaft Bernhard Maschke Gerardo Escobar | 2002 | Automatica2002，，4： | 1 |
| 13 | Interconnection and damping assignment passivity -based control of port - controlled Hamihonian systems 显示文摘 | Romeo Ortega Arian van der Schaftb Bernhard Maschkec Gerardo Escobar | 2002 | Automatica2002，，38： | 1 |
| 14 | Model based current mode control design and experimental validation for a 3φ rectifier under unbalanced grid voltage conditions显示文摘This paper addresses the control design and the experimental validation of a current mode control for a three phase voltage source rectifier. The proposed control law is able to fulfill the voltage regulation and the current tracking control objectives despite of unbalanced and distorted grid voltages. The proposed control law consists of two loops, which are referred as inner tracking loop and the outer voltage regulation loop. The inner loop is designed to provide damping to the system, which also includes and adaptive mechanism. The construction of the current reference is based on the positive component detection of thegrid voltage. Therefore, the current produced by the power rectifier is proportional to the fundamental component of the grid voltage, despite of the presence of unbalanced grid voltages. The voltage regulation loop is designed as a proportional-integral controller, which is aimed to regulate the DC output voltage to a desired level. Finally, experimental results are obtained in an experimental prototype of2 kW to evaluate the performance of the proposed controller. | P.R.MARTíNEZ-RODRIGEZ Jose M.SOSA Samuel ITURRIAGA-MEDINA Gerardo ESCOBAR Gerardo VáZQUEZ-GUZMáN Andres A.VALDEZ-FERNáNDEZ | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，4： | 1 |
| 15 | Analysis and design of direct power control (DPC) for a three phase synchronous rectifier via output regulation subspaces显示文摘 | Escobar Gerardo Stankovic A M Carrasco J M | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
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