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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Accelerated degradation tests:Modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu C J | 1998 | Technometrics1998，40，： | 1 |
| 3 | Influence of nanofiltration on distribution system biostability显示文摘 | Escobar I Randall A | 1999 | AWWA1999，91，6： | 1 |
| 4 | Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation显示文摘 | Escobar J Frank J W Suryawan A | 2005 | American Journal of PhysiologFEndocrinology and Metabolism2005，288，： | 1 |
| 5 | Accelerated degradation tests:modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu J C | 1998 | Technometrics1998，40，2： | 1 |
| 6 | Novel robotic da Vinci instruments for lap aroendoscopic single-site surgery显示文摘 | Haber G P White M A Autorino R Escobar P F Kroh M D Chalikonda S | 2010 | Urology2010，76，： | 1 |
| 7 | Assimilable organic carbon (AOC) and biodegradable dissolved organic carbon (BDOC) : complementary measurements 显示文摘 | ESCOBAR I C RANDALL A A | 2001 | Wat Res2001，35，18： | 1 |
| 8 | Regulation of cardiac and skeletal muscle protein synthesis by individual branched chain amino acids in neonatal pigs显示文摘 | Escobar J Frank J W Suryawan A | 2006 | American Journal of PhysiologFEndocrinology and Metabolism2006，290，： | 1 |
| 9 | Bacterial growth in distri- bution systems Effect of assimilable organic carbon and biode- gradable dissolved organic carbon显示文摘 | Escobar I C Randall A A Taylor J S | 2001 | Environmental Science -Technology2001，35，17： | 1 |
| 10 | Determination of aflatoxin B1 in food and feedstuffs in Cuba (1990 through 1996) using an immunoenzymatic reagent kit (Aflacen)显示文摘 | Escobar A Regueiro OS | 2002 | Journal of Food Protection2002，65，1： | 1 |
| 11 | Dissipativity-based adaptive and robust control of UPS显示文摘 | Escobar G Stankovic A M | 2001 | IEEE Transactions on Industrial Electronics2001，48，2： | 1 |
| 12 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 13 | Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990-2000 显示文摘 | Chiavetta JA Escobar M Newman A | 2003 | CMAJ2003，169，8： | 1 |
| 14 | Evaluation of Sapindus Saponaria as a defaunating agent and its effects on different ruminal digestion parameters显示文摘 | Diaz A Avendano M Escobar A | 1993 | Livestock Research for Rural Development1993，，5： | 1 |
| 15 | Influence of NF on distribution system biostability 显示文摘 | ESCOBAR I C RANDALL A A | 1999 | AWWA1999，91，6： | 1 |
| 16 | Identification of suitable Copulas for bivariate frequency analysis of flood peak and flood volume data显示文摘 | Chowdhary H Escobar L A Singh V P | 2011 | Hydrology Research2011，42，23： | 1 |
| 17 | Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus显示文摘 | Cervantes M Gonzalez-Vidal MD Ruelas R Escobar A Morali G | 2002 | Arch Med Res2002，33，： | 1 |
| 18 | Determination of aflatoxins B1 in food and feedstuffs in Cuba using a immunoenzymatic regent kit显示文摘 | Escobar A Regueiro O S | 2002 | Journal of Food protection2002，65，： | 1 |
| 19 | Recovery of placer gold using the Knelson Concentrator显示文摘 | MEZA L A HARTMANN W ESCOBAR C A | 1994 | Innovations in Mineral Processing1994，，1： | 1 |
| 20 | (EMCA) 显示文摘 | Simpkins F Drake R Escobar PF A phase II trial of pa-clitaxel caAoplatin and bevacizumab in advanced and recurrentendometrial carcindipa | 2015 | Gynecol Oncol2015，136，2： | 1 |
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