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| 1 | Acute development of collateral circulation and therapeutic prospects in ischemic stroke显示文摘In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic transformation.We have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is achieved.Contrary to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact arteries.We believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein. | Eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota | 2016 | Neural Regeneration Research2016，11，3： | 19 |
| 2 | Strategies to prevent hypertrophic scar formation:a review of therapeutic interventions based on molecular evidence显示文摘Once scar tissues mature,it is impossible for the surrounding tissue to regenerate normal dermal tissue.Therefore,it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar formation.Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing.However,the underlying mechanisms of hypertrophic scar development are poorly understood.The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation,focusing on strategies excluding therapeutic agents of internal use.Treatment aimed at molecular targets,including cytokines,will be future options to prevent and treat hypertrophic scars.More basic studies and clinical trials,including combination therapy,are required to investigate the mechanisms and prevent hypertrophic scar formation. | Eri Shirakami Sho Yamakawa Kenji Hayashida | 2020 | Burns & Trauma2020，8，1： | 18 |
| 3 | Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients显示文摘AIM:To investigate the therapeutic efficacy and safety of continuous autotransfusion system(CATS) during liver transplantation of hepatocellular carcinoma patients.METHODS:Eighty-three hepatocellular carcinoma(HCC) patients who underwent liver transplantation with intraoperative CATS(n = 24,CATS group) and without(n = 59,non-CATS group) between April 2006 and November 2011 at the Liver Transplant Institute of Inonu University were analyzed retrospectively.Postoperative HCC recurrence was monitored by measuring alpha-fetoprotein(AFP) levels at 3-mo intervals and performing imaging analysis by thoracoabdominal multidetector computed tomography at 6-month intervals.Inter-group differences in recurrence and correlations between demographic,clinical,and pathological data were assessed by ANOVA and χ 2 tests.Overall and disease-free survivals were calculated by the univariate Kaplan-Meier method.RESULTS:Of the 83 liver transplanted HCC patients,89.2% were male and the overall mean age was 51.3 ± 8.9 years(range:18-69 years).The CATS and nonCATS groups showed no statistically significant differences in age,sex ratio,body mass index,underlying disease,donor type,graft-to-recipient weight ratio,Child-Pugh and Model for End-Stage Liver Disease scores,number of tumors,tumor size,AFP level,Milan and University of California San Francisco selection criteria,tumor differentiation,macrovascular invasion,median hospital stay,recurrence rate,recurrence site,or mortality rate.The mean follow-up time of the nonCATS group was 17.9 ± 12.8 mo,during which systemic metastasis and/or locoregional recurrence developed in 25.4% of the patients.The mean follow-up time for the CATS group was 25.8 ± 15.1 mo,during which systemic metastasis and/or locoregional recurrence was detected in 29.2% of the patients.There was no significant difference between the CATS and non-CATS groups in recurrence rate or site.Additionally,no significant differences existed between the groups in overall or disease-free survival.CONCLUSION:CATS is a safe procedure and may decrease the risk of tumor recurrence in HCC patients. | Sami Akbulut Cuneyt Kayaalp Mehmet Yilmaz Volkan Ince Dincer Ozgor Koray Karabulut Cengiz Eris Huseyin Ilksen Toprak Cemalettin Aydin Sezai Yilmaz | 2013 | World Journal of Gastroenterology2013，19，10： | 17 |
| 4 | Transport, signaling, and homeostasis of potassium and sodium in plants显示文摘Potassium(Kt) is an essential macronutrient in plants and a lack of Ktsignificantly reduces the potential for plant growth and development. By contrast, sodium(Nat),while beneficial to some extent, at high concentrations it disturbs and inhibits various physiological processes and plant growth. Due to their chemical similarities, some functions of Kt can be undertaken by Natbut Kthomeostasis is severely affected by salt stress, on the other hand. Recent advances have highlighted the fascinating regulatory mechanisms of Kt and Nattransport and signaling in plants. This review summarizes three major topics:(i) the transport mechanisms of Ktand Natfrom the soil to the shoot and to the cellular compartments;(ii) the mechanisms through which plants sense and respond to Ktand Natavailability; and(iii) the components involved in maintenance of Kt/Nathomeostasis in plants under salt stress. | Eri Adams Ryoung Shin | 2014 | Journal of Integrative Plant Biology2014，56，3： | 16 |
| 5 | 中西医结合治疗SARS的系统评价与Meta-分析显示文摘目的评价中西医结合治疗严重急性呼吸综合征(SARS)的疗效。方法作者检索了Cochrane图书馆、PubMed、中国生物医学文献数据库、中文期刊全文数据库、中国科技文献数据库、Cochrane协作网补充医学领域试验数据库和AMED截至2004年4月。纳入所有中西医结合治疗SARS与单用西医治疗比较的随机对照试验。根据随机分配方法、随机方案隐藏、盲法和意向治疗分析评价纳入研究的质量。对非随机的临床对照研究进行探索性分析。两名作者独立提取资料、评价质量及结局。用Meta分析方法对资料进行定量综合。结果共纳入8篇中西医结合与西医比较治疗共计488例SARS患者的随机对照试验。试验的方法学质量普遍较低。Meta分析表明:中西医结合疗法显著降低患者的病死率(相对获益系数RR0.32;5%可信区间0.12~0.91),并减少激素治疗SARS患者发生真菌感染(0.35;0.14~0.90)的可能性。同时,中西医结合疗法缩短发热的时间〔权重均数差-0.83(天);-1.30~-0.35〕、症状缓解时间(-1.23;-.09~-0.37])以及胸部X线异常的持续时间(-2.61;-3.74~-1.49)。对生活质量或激素用量差异无显著性。试验未报道中西医结合治疗的不良反应。结论中西医结合治疗SARS具有降低病死率、减少继发真菌感染、缩短症状及发热时间、减轻肺部炎症的效果。但由于试验的质量较低,现有的证据还不足以得出肯定的结论。 | 刘建平 Eri cManheimer 施毅 Christian Gluud | 2005 | 中国中西医结合杂志2005，25，12： | 11 |
| 6 | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA显示文摘Hepatitis B virus(HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host mi RNAs and may deregulate mi RNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viralderived mi RNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBVderived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBVinduced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics. | Kazuma Sekiba Motoyuki Otsuka Motoko Ohno Mari Yamagami Takahiro Kishikawa Tatsunori Suzuki Rei Ishibashi Takahiro Seimiya Eri Tanaka Kazuhiko Koike | 2018 | World Journal of Gastroenterology2018，24，21： | 10 |
| 7 | Low-grade myofibroblastic sarcoma of the palate显示文摘Low-grade myofibroblastic sarcoma(LGMS) is a rare,malignant tumor with myofibroblastic differentiation.Despite it being classified as a distinct entity by the World Health Organization,a few cases were reported in the oral and maxillofacial region.Here,a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate.Based on the histological and immunohistochemical features,a diagnosis of LGMS was established.The tumor was resected,and no recurrence was observed over 2 years.Although the tongue is the most preferred site for LGMS,it may occur in any region of the oral cavity. | Tomohiro Yamada Tomohide Yoshimura Naoya Kitamura Eri Sasabe Seiji Ohno Tetsuya Yamamoto | 2012 | International Journal of Oral Science2012，4，3： | 9 |
| 8 | Age-dependent eradication of Helicobacter pylori in Japanese patients显示文摘AIM:To determine the general risk factors affecting the failure rate of first-line eradication therapy in Japanese patients with Helicobacter pylori(H.pylori)infection.METHODS:The present study enrolled 253 patients who had an H.pylori infection,underwent gastroendoscopy,and were treated with H.pylori eradication therapy.Eradication therapy consisted of 30 mg lansoprazole plus 750 mg amoxicillin and 400 mg clarithromycin twice daily for 7 d.All of the patients underwent a 13 C urea breath test at least 1 mo after the completion of eradication therapy.The current study investigated the independent factors associated with successful H.pylori eradication using a multiple logistic regression analysis.RESULTS:The overall success rate in the patients was 85.8%.Among the general factors examined in the multivariate analyses,only having an age less than 50 years was found to be significantly associated with a poor response to H.pylori eradication.Moreover,side effects were the only clinical factors in the patients who were under 50 years of age that significantly influenced the poor response to H.pylori eradication.CONCLUSION:H.pylori-positive elderly patients should undergo eradication therapy.In addition,it is necessary to improve H.pylori eradication therapy in younger patients. | Satoshi Mamori Akihiro Higashida Fumiaki Kawara Katsuhiro Ohnishi Akihiko Takeda Eri Senda Cho Ashida Hajime Yamada | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 9 | Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”显示文摘MK615, a compound extracted from the Japanese apricot 'Prunus mume ' has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis appeared.Sorafenib was administered, but was not effective.Then, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects. | Takashi Hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 10 | The New Era of Organ Transplantation in China显示文摘 | Jie-Fu Huang Hai-Bo Wang Shu-Sen Zheng Yong-Feng Liu Bing-Yi Shi Zhong-Yang Shen Sheng-Shou Hu Qi-Fa Ye Wu-Jun Erie Xiao-Shun He Jing-Yu Chen Feng Huo Sing Du Jing Fan Yan-Hong Guo Zong-Jiu Zhang | 2016 | Chinese Medical Journal2016，，16： | 6 |
| 11 | Three global conditions for biodiversity conservation and sustainable use: an implementation framework显示文摘‘Nature and its vital contributions to people,which together embody biodiversity and ecosystem functions and services,are deteriorating worldwide’[1].The United Nations Convention on Biological Diversity(CBD)is intended to ensure conservation of biodiversity,its wise use,and sharing of benefits from use of genetic resources.Through it,the Strategic Plan(SP)for Biodiversity 2011-2020 was created to make progress toward a vision of humanity‘Living in Harmony with N ature’by 2050[2].W hen that vision is realized,biodiversity will be valued,conserved,restored,and wisely used,so it can maintain ecosystem services and sustain a healthy planet. | Harvey Locke Erie C.Ellis Oscar Venter Richard Schuster Keping Ma Xiaoli Shen Stephen Woodley Naomi Kingston Nina Bhola Bernardo B.N.Strassburg Axel Paulsch Brooke Williams James E.M.Watson | 2019 | National Science Review2019，6，6： | 6 |
| 12 | 不同土壤水势下贝莱斯芽孢杆菌B006菌剂对茄子的促生增产作用显示文摘为了明确水肥一体化灌溉系统中不同土壤水势条件下,施用芽孢杆菌B006菌剂对茄子生长及产量的促进作用,采用灌根法测定施用芽孢杆菌B006菌剂(1′107CFU·mL-1)对盆栽茄子幼苗生长的影响。在日光温室开展两因子、两水平交互田间小区试验,在土壤水势分别为-30 kPa和-40 kPa条件下,设置施用和不施用(对照)芽孢杆菌B006菌剂共4组处理。各处理均施用278.77 kg·hm-2化学肥料(N/P/K为17∶9∶34)。采用电子张力计监测土壤水势,采用水肥一体化自动灌溉系统进行灌溉。分别在移栽时和定植后30 d浇灌浓度为1×107CFU·mL-1的B006菌剂稀释液。35 d后测定茄子的株高、茎粗、叶绿素含量和地上部干质量,50 d后调查茄子开花数,每次施肥前测定土壤速效氮、磷、钾含量,收获期测定产量,收获后测定根长和根干质量。结果表明:施用B006菌剂处理的盆栽茄子株高、茎粗、根长和根干质量比对照分别提高了16.7%、20.7%、28.7%和67.0%。在日光温室大棚试验中,施用B006菌剂处理土壤的速效磷、速效钾含量均低于对照;土壤水势-30 kPa和-40 kPa条件下,施用B006菌剂处理的茄子产量比对照分别提高了24.5%和18.1%。当灌溉量从804.88 m3·hm-2减少到574.91 m3·hm-2时,施用B006菌剂的两处理之间产量无显著差异。综上所述,施用芽孢杆菌B006菌剂可以促进茄子对氮、磷、钾的吸收,提高肥料利用率,从而促进植物生长,甚至在少水灌溉条件下不降低茄子产量。 | 耿妍 郭荣君 张爱香 GOVRIN Eri Moshe 李世东 | 2020 | 农业资源与环境学报2020，37，3： | 5 |
| 13 | 贝莱斯芽胞杆菌B006对不同水肥条件下娃娃菜生长及软腐病防效的影响显示文摘贝莱斯芽胞杆菌B006是一株高效生防菌株,但其在不同水肥条件下的防病促生效果尚不明确。本研究通过盆栽试验测定了不同土壤含水量和施肥条件下B006菌剂对娃娃菜生长及对软腐病防效的影响,结果表明:在土壤含水量为14%、施肥量为3.57 g/kg土的条件下,播种时沟施5 g B006菌剂(菌含量为1×10^(7)CFU/g),出苗后浇灌B006菌悬液(3×10^(8)CFU/m L)可明显降低娃娃菜的发病率和病情指数,与相同条件下未施用B006菌剂处理相比,防效达77.4%。在日光温室开展土壤水势、施肥量及B006菌剂施用随机区组交互试验,结果表明:在土壤水势-50 kPa和追肥量1049.5 kg/hm^(2)(N/P/K=18/5/13)条件下,施用B006菌剂可以促进植株生长,与土壤水势和追肥量分别为-50 kPa×1499.3 kg/hm^(2)和-30 kPa×1499.3 kg/hm^(2)的处理相比,娃娃菜产量分别提高了8.6%和11.2%。综上所述,适当少水、少肥并施用贝莱斯芽胞杆菌B006菌剂可以明显控制娃娃菜软腐病的发生,促进植物生长,并显著提高娃娃菜产量。 | 耿妍 张世昌 郭荣君 张爱香 Govrin Eri Moshe 李世东 沈瑞清 罗明 | 2021 | 中国生物防治学报2021，37，3： | 4 |
| 14 | Debris flow susceptibility and propagation assessment in West Koyulhisar, Turkey显示文摘Turkey is highly prone to landslides because of the geological and geographic location.The study area,which is located in a tectonically active region,has been significantly affected by mass movements.Flow type landslides are frequently observed due to this location.This study aims at determining the source area and propagation of debris flows in the study area.We used the heuristic method to extract source areas of debris flow,and then used receiver operating characteristic(ROC)curve analysis to assess the performance of the method,and finally calculated the Area under curve(AUC)values being 83.64%and 80.39%for the success rate and prediction rate,respectively.We calculated potential propagation area and runout distance with Flow-R software.In conclusion,the obtained results(susceptibility map,propagation and runout distance)are very important for decisionmakers at the region located on an active fault zone,which is highly prone to natural disasters.The outputs of this study could be used in site selection studies,designing erosion prevention systems and protecting existing human-made structures. | Ali POLAT Dursun ERİK | 2020 | Journal of Mountain Science2020，17，11： | 4 |
| 15 | A case of very large intrahepatic bile duct adenoma followed for 7 years显示文摘A 70-year-old man was referred to our hospital due to abnormal liver function. A tumor of 92 mm × 61 mm was detected on ultrasound screening of the left liver lobe. Although the tumor was suspected to be intrahepatic bile duct carcinoma, he had chronic heart disease and was unable to undergo surgery. Therefore, he was followed without further testing. No increase in tumor serum markers or tumor size was observed for the subsequent 7 years. We continued to suspect intrahepatic bile duct carcinoma, and we decided to perform a tumor biopsy. Tumor biopsy findings indicated intrahepatic bile duct adenoma(BDA), which is a rare benign epithelial liver tumor typically ranging from 1 mm to20 mm. We herein report a case of very large BDA followed for 7 years. | Futa Koga Hiroto Tanaka Seigo Takamatsu Shinnichi Baba Hiroshi Takihara Akioko Hasegawa Eri Yanagihara Taro Inoue Toshihiro Nakano Chie Ueda Wataru Ono | 2012 | World Journal of Clinical Oncology2012，3，4： | 3 |
| 16 | Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats显示文摘AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced hepatotoxicity.METHODS:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg MTX.Eleven of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control group.Structural and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total bilirubin.RESULTS:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme activities[3.22(2.54-3.62)μmol/g and 69.22(61.13-100.88)U/g,P<0.05 and P<0.01vs model group respectively].CONCLUSION:MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress,and cytoprotective agents(NAC>AMF>ASC)may alleviate MTX hepatotoxicity. | Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 17 | Evaluation of an erosion-sediment transport model for a hillslope using laboratory flume data显示文摘Climate change can escalate rainfall intensity and cause further increase in sediment transport in arid lands which in turn can adversely affect water quality. Hence, there is a strong need to predict the fate of sediments in order to provide measures for sound erosion control and water quality management. The presence of microtopography on hillslopes influences processes of runoff generation and erosion, which should be taken into account to achieve more accurate modelling results. This study presents a physically based mathematical model for erosion and sediment transport coupled to one-dimensional overland flow equations that simulate rainfall-runoff generation on the rill and interrill areas of a bare hillslope. Modelling effort at such a fine resolution considering the flow connection between interrill areas and rills is rarely verified. The developed model was applied on a set of data gathered from an experimental setup where a 650 cm×136 cm erosion flume was pre-formed with a longitudinal rill and interrill having a plane geometry and was equipped with a rainfall simulator that reproduces natural rainfall characteristics. The flume can be given both longitudinal and lateral slope directions. For calibration and validation, the model was applied on the experimental results obtained from the setup of the flume having 5% lateral and 10% longitudinal slope directions under rainfall intensities of 105 and 45 mm/h, respectively. Calibration showed that the model was able to produce good results based on the R2(0.84) and NSE(0.80) values. The model performance was further tested through validation which also produced good statistics(R2=0.83, NSE=0.72). Results in terms of the sedigraphs, cumulative mass curves and performance statistics suggest that the model can be a useful and an important step towards verifying and improving mathematical models of erosion and sediment transport. | Anya Catherine CARGUELLES MinJae JUNG Kristine Joy BMALLARI GiJung PAK Hafzullah AKSOY Levent M KAVVAS Ebru ERIS JaeYoung YOON YoungJoon LEE SeonHwa HONG | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 18 | Noise Reduction and Surge Margin Improvement Using Tapered Diffuser Vane in a Centrifugal Compressor显示文摘Improvement of surge margin and reduction of interaction tone noise radiated from a centrifugal compressor with a vaned diffuser is discussed from experiments and CFD analyses.Two types of one-side tapered diffuser vanes,which are shroud-and hub-side tapered vanes,were used in the experiments.The height of the leading edge of the tapered vanes varied from 100% to 10%.Both types of tapered vanes are effective for the reduction of the interaction tone noise radiated from the compressor,because of the smaller interaction area between impeller-discharge flow and diffuser vane surface.Especially,the hub-side tapered diffuser vane suppresses the evolution of the leading-edge vortex,which causes reverse-flow in the diffuser passage.Furthermore,the hub-side tapered diffuser vane,which has an optimized diffuser leading edge shape,can improve the compressor pressure-rise characteristics at low-flow operation and can enlarge the surge margin. | Takashi Goto Eri Ohmoto Yutaka Ohta Eisuke Outa | 2010 | Journal of Thermal Science2010，19，1： | 3 |
| 19 | Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes显示文摘Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of insulin.Diabetic foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic patients.The aim of this study is to provide an evidence-based overview of diabetic foot complications.Due to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin lesions.In patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and amputations.Hyperglycemia compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound healing.In addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial resistance.As a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be overlooked.Issues associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed annually.Although antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation. | Tatjana Matijević Jasminka Talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec | 2023 | World Journal of Clinical Cases2023，11，8： | 2 |
| 20 | Greater Incidence of Delirium during Recovery from Sevoflurane Anesthesia in Preschool Boys显示文摘 | Jun Aono Wasa Ueda Kikyo Mamiya Eri Takimoto Masanobu Manabe | 1997 | Anesthesiology1997，，： | 2 |
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