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| 1 | Micro air vehicle-motivated computational biomechanics in bio-flights:aerodynamics,flight dynamics and maneuvering stability显示文摘Aiming at developing an effective tool to unveil key mechanisms in bio-flight as well as to provide guidelines for bio-inspired micro air vehicles(MAVs) design,we propose a comprehensive computational framework,which integrates aerodynamics,flight dynamics,vehicle stability and maneuverability.This framework consists of(1) a Navier-Stokes unsteady aerodynamic model;(2) a linear finite element model for structural dynamics;(3) a fluidstructure interaction(FSI) model for coupled flexible wing aerodynamics aeroelasticity;(4) a free-flying rigid body dynamic(RBD) model utilizing the Newtonian-Euler equations of 6DoF motion;and(5) flight simulator accounting for realistic wing-body morphology,flapping-wing and body kinematics,and a coupling model accounting for the nonlinear 6DoF flight dynamics and stability of insect flapping flight.Results are presented based on hovering aerodynamics with rigid and flexible wings of hawkmoth and fruitfly.The present approach can support systematic analyses of bio- and bio-inspired flight. | Hao Liu Toshiyuki Nakata Na Gao Masateru Maeda Hikaru Aono Wei Shyy | 2010 | Acta Mechanica Sinica2010，26，6： | 8 |
| 2 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 3 | Greater Incidence of Delirium during Recovery from Sevoflurane Anesthesia in Preschool Boys显示文摘 | Jun Aono Wasa Ueda Kikyo Mamiya Eri Takimoto Masanobu Manabe | 1997 | Anesthesiology1997，，： | 2 |
| 4 | Near wake vortex dynamics of a hovering hawkmoth显示文摘Numerical investigation of vortex dynamics innear wake of a hovering hawkmoth and hovering aerody-namics is conducted to support the development of abiology-inspired dynamic flight simulator for flapping wing-based micro air vehicles.Realistic wing-body morphologiesand kinematics are adopted in the numerical simulations.The computed results show 3D mechanisms of vortical flowstructures in hawkrnoth-like hovering.A horseshoe-shapedprimary vortex is observed to wrap around each wing duringthe early down- and upstroke; the horseshoe-shaped vortexsubsequently grows into a doughnut-shaped vortex ring withan intense jet-flow present in its core,forming a downwash.The doughnut-shaped vortex rings of the wing pair eventu-ally break up into two circular vortex tings as they propagatedownstream in the wake.The aerodynamic yawing and roll-ing torques are canceled out due to the symmetric wing kine-matics even though the aerodynamic pitching torque showssignificant variation with time.On the other hand,the time-varying the aerodynamics pitching torque could make thebody a longitudinal oscillation over one flapping cycle. | Hikaru Aono Wei Shyy Hao Liu | 2009 | Acta Mechanica Sinica2009，25，1： | 2 |
| 5 | Epidemiology of Degenerative Lumbar Scoliosis: A Community-Based Cohort Study显示文摘 | Shizuo Jimbo Tetsuya Kobayashi Kiyoshi Aono Yuji Atsuta Takeo Matsuno | 2012 | Spine2012，，20： | 2 |
| 6 | Effect of antipsychotic replacement with quetiapine on the symptoms and quality of life of schizophrenic patients with extrapyramidal symptoms 显示文摘 | Taniguchi T Sumitani S Aono M | 2006 | Hum Psychopharmacol Clin Exp2006，21，7： | 1 |
| 7 | Reduction of dental plaque deposition in humans by oolong tea extract显示文摘 | Ooshima T Minami T Aono W | 1994 | Caries Res1994，28，3： | 1 |
| 8 | Fitting a woven-cloth model to a curved surface: mapping algorithms显示文摘 | AONO M BREEN D E WOZNY M J | 1994 | Computer Aided Design1994，26，4： | 1 |
| 9 | Sot-get derived mesoporous silica films using amphiphilic triblock copolymers显示文摘 | KITAZAWA N NAMBA H AONO M | 2003 | Journal of Non-crystalline Solids2003，332，： | 1 |
| 10 | A novel role for defensins in intesti- nal homeostasis: regulation of IL-1beta secretion 显示文摘 | Shi J Aono S Lu W | 2007 | J Im- munol2007，179，： | 1 |
| 11 | Characteristics of lipid and fatty acid of marine gastropod Turbo cornutus : High levels of arachidonic and n -3 docosapentaenoic acid显示文摘 | Hiroaki Saito Hideaki Aono | 2014 | Food Chemistry2014，，： | 1 |
| 12 | Molecular and functional char- acterization of bovine β-delensin-1 显示文摘 | Aono S Li C Zhang G | 2006 | Veterinary Immu nology and Immunopathology2006，113，1： | 1 |
| 13 | Crystallo-graphic characterization and NO2 gas sensing property of LnFeO3 prepared by thermal decomposition of Ln--Fe hexacyanocomplexes, Ln[Fe(CN)6]·nH2O, Ln=La, Nd, Sm, Gd, and Dy显示文摘 | Aono H Traversa E Sakamoto M Sadaoka Y | | 0，，02： | 1 |
| 14 | Lithocholic acid side-chain cleavage to produce 17-keto or 22-aldehyde steroids by Pseudomonas putida strain ST-491 grown in the presence of an organic solvent, diphenyl ether显示文摘 | Suzuki Y Doukyu N Aono R | 1998 | Biosci Biotechnol Biochem1998，62，11： | 1 |
| 15 | Influence of superoxide generating system, vitamin E, and superoxide dismutase on radiation consequences显示文摘 | Inouye B Aono K Iida S | 1979 | Physiol Chem Phys1979，11，2： | 1 |
| 16 | Wireless secret key genera-tion exploiting reactance domain scalar response of multipath fading channels显示文摘 | AONO T HIGUCHI K OHIRA T | | 0，，11： | 1 |
| 17 | Propofol improves recovery from paraquat acute toxicity in vitro and in vivo显示文摘 | J. Ariyama H. Shimada M. Aono H. Tsuchida K.-I. Hirai | 2000 | Intensive Care Medicine2000，，7： | 1 |
| 18 | Effect of ooplast activation on the development of oocytes following nucleus transfer in cattle显示文摘 | Kono T Sotomaru Y Aono F | 1994 | Theriogenology1994，41，： | 1 |
| 19 | Data embedding algorithms for geometrical and non-geomelrical targets in three-dimensional polygo- nal models显示文摘 | Ohbuchi R Masuda H Aono N | 1998 | Computer Commtmicafion1998，21，15： | 1 |
| 20 | Complete genome sequence and comparative analysis of Shewanella violacea, a psychrophilic and piezophilic bacterium from deep sea floor sediments显示文摘 | AONO E BABA T ARA T | 2010 | Mol Biosyst2010，6，7： | 1 |
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