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| 1 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 4 | Effects of herbivory on the reproductive effort of 4 prairie显示文摘 | Erica S Kate L B Johannes M H K | 2002 | BMC Ecology2002，2，： | 1 |
| 5 | American Employer Salary Surveys and labor Economics Research: Issues and Contributions显示文摘 | Groshen Erica L | 1996 | Annales d''Economie et de Statistique1996，，4142： | 1 |
| 6 | ( + )-And (-)-borneol: efficacious positive modulators of GABAaction at human recombinant ell,82 2L GABAA receptors 显示文摘 | Renee E Granger Erica L Campbell Graham A R Johnston | 2005 | Bio- chem Pharmaco12005，69，： | 1 |
| 7 | Identication of bronchioalveolar stem cells in normal lung and lung cancer显示文摘 | Kim CF Erica L Jackson AE | 2005 | Cell2005，121，6： | 1 |
| 8 | Gene therapy for diabetes:metabolic effects of helperdependent adenoviral exendin 4 expression in a diet-induced obesity mouse model显示文摘 | Susan L S Erica V G Vijay Y | 2008 | Mol Ther2008，16，11： | 1 |
| 9 | Synthesis and characterization of xylan-coated magnetite microparticles 显示文摘 | Amanda K Andriola Silva Erica L da Silva Elquio E Oliveira | 2007 | lnternational Journal of Pharmaceutics2007，334，： | 1 |
| 10 | Different farming and water regimes in Italian rice fields affect ar- buscular mycorrhizal fungal soil communities 显示文摘 | ERICA L MARTA V ALGUACIL M M | 2011 | Eco- logical Applications2011，21，5： | 1 |
| 11 | Investigating the Antimalarial Action of 1,2 ,4-Trioxolanes with Fluorescent ChemicalProbes显示文摘 | Carmony L H Erica M W L Sumit S M | 2011 | J Med Chem2011，54，23： | 1 |
| 12 | Partnership in a Dynamic Production System with Unobservable Actions and Non-contractible Output 显示文摘 | Erica L Plambeck Terry A Taylor | 2006 | Management Science2006，52，10： | 1 |
| 13 | Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer显示文摘 | Carla F Bender Kim Erica L | 2005 | Cell2005，121，： | 1 |
| 14 | Improved ablation resis- tance of C-C composites using zirconium diboride and boron carbide显示文摘 | Erica L Corral Luke S Walker | 2010 | J Eur Ceram Soc2010，30，11： | 1 |
| 15 | Sell the plant?the impact of contract manufacturing on innovation,capacity,and profitability显示文摘 | Taylor Terry A | 2005 | Management Science2005，51，1： | 1 |
| 16 | MDR1(ABCB1) G1199A(Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents显示文摘 | Erica L Matthew H Crouthamel H | 2009 | Cancer Chemother Pharmacol2009，64，23： | 1 |
| 17 | Plasticity of marrow-derived stem cells显示文摘 | Erica L H Li C Diane S K | 2003 | Blood2003，102，： | 1 |
| 18 | Genetic effects on women's positive mental health:Do marital relation- ships and social support matter? 显示文摘 | Erica L Spotts N L Pedersen J M | 2005 | Journal of Family Psychology2005，19，3： | 1 |
| 19 | Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthasel显示文摘 | Daoyan Wei Erica L Richardson | 2005 | Cancer Res2005，63，5： | 1 |
| 20 | On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development 显示文摘 | Heike W Erica M Marco T Jeff A L Detlef W | 2010 | Development2010，137，： | 1 |
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