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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Comment on: Statin use and risk of diabetes mellitus显示文摘In manuscript named 'Statin use and risk of diabetes mellitus' by Chogtu et al, authors defined that pravastatin 40 mg/dL reduced the risk of diabetes by 30% in West of Scotland Coronary Prevention study. In fact, pravastatin 40 mg/d L reduced coronary heart disease risk approximately 30% in mentioned study. | Mehmet Ali Eren Tevfik Sabuncu Hüseyin Karaaslan | 2016 | World Journal of Diabetes2016，7，8： | 2 |
| 3 | Enzymatic pre-preatment of cotton, part 1 : desizing and glucose generation in desiz- ing liquor显示文摘 | ANIS P DAVULCU A EREN H A | 2008 | Fibers & Textiles in Eastern Europe2008，16，4： | 1 |
| 4 | Polymerization of maleic an- hydride-modified plant oils with polyols显示文摘 | Eren T Selim H Wool R | 2003 | Journal of Applied Pol- ymer Science2003，90，： | 1 |
| 5 | Afterclearing by ozonation:a novel approach for disperse dyeing of polyester 显示文摘 | Eren H A | 2006 | Coloration Technology2006，122，6： | 1 |
| 6 | Removal of Titanium Impurities from Feldspar Ores by New Notation Collectors 显示文摘 | Celik M S Can I Eren R H | 1998 | Minerals Engineering1998，11，12： | 1 |
| 7 | Entrepreneurialaspirations,motivations, and their drivers显示文摘 | HESSELS J G ELD EREN M V T H U R IK R | 2008 | Small BusinessEconomics2008，31，3： | 1 |
| 8 | Simultaneous afterclearing and decolorisation by ozonation after disperse dyeing of polyester显示文摘 | Eren H A | 2007 | Coloration Technology2007，123，4： | 1 |
| 9 | Risk factors affecting outcome and morbidity in the surgical management of bronchiectasis显示文摘 | Eren S Esme H Avci A | 2007 | J Thorae Cardiovasc Surg2007，134，2： | 1 |
| 10 | One step hydroxybromina- tion of fatty acid derivatives显示文摘 | Eren Tarik Selim H Kusefoglu | 2004 | Eur J Lipid Sci Techn2004，106，1： | 1 |
| 11 | External torque application on antilock brake systems 显示文摘 | Eren H Goktan A O | 2001 | Proceedings of the Institution of Mechanical Engineers2001，215，7： | 1 |
| 12 | A rare cause of intestinal obstruction in the adult : Morgagni's hernia 显示文摘 | Eren S Gtimus H Okur A | 2003 | Hernia2003，7，2： | 1 |
| 13 | The effect of aprotinin on isehemia-reperfusion injury in an in situ normothermie ischemic lung model显示文摘 | Esme H Balci AE | 2003 | Eur J Cardiothorac Surg2003，23，1： | 1 |
| 14 | The factorsaffecting persistent pneumothorax and mortality in neonatalpneumothorax显示文摘 | Esme H Dogru O Eren S Korkmaz M Solak O | 2008 | Turk Pediatr2008，50，3： | 1 |
| 15 | Effects of dietary rosemary,rosemary volatile oil and vitamin E on broiler performance,meat quality and serum SOD activity显示文摘 | Yesilbag D Eren M Agel H | 2011 | British Poultry Science2011，52，4： | 1 |
| 16 | Effect of periodontal treatment on IL-1beta,IL-1ra,and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis 显示文摘 | Toker H Poyraz O Eren K | 2008 | J Clin Periodontol2008，35，6： | 1 |
| 17 | Two eases of Wegener's granulomatosis involving the pituitary显示文摘 | Roberts GA Eren E Sinclair H | 1995 | Clin Endocrinol(Oxf)1995，42，： | 1 |
| 18 | An experimental study on the bond strength between reinforcement bars and concrete as a function of concrete cover, strength and corrosion level 显示文摘 | YALCINER H EREN O SENSOY S | 2012 | Cement and Concrete Research2012，42，5： | 1 |
| 19 | Evaluation of macular changes after uncomplicated phacoemul- sification surgery by optical coherence tomography显示文摘 | Perente I Utine CA Ozturker C Cakir M Kaya V Eren H | 2007 | Cur Eye Res2007，32，3： | 1 |
| 20 | Which is the best technique for endometrial sampling? Aspiration (pipelle) versus dilatation and curettage (D&C) 显示文摘 | Demirkiran F Yavuz E Erene] H | 2012 | Arch Gynecol Obstet2012，286，5： | 1 |
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