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| 1 | Investigation into improving the efficiency and accuracy of CFD/DEM simulations显示文摘The Euler-Lagrange approach combined with a discrete element method has frequently been applied to elucidate the hydrodynamic behavior of dense fluid-solid flows in fluidized beds.In this work,the efficiency and accuracy of this model are investigated.Parameter studies are performed;in these studies,the stiffness coefficient,the fluid time step and the processor number are varied under conditions with different numbers of particles and different particle diameters.The obtained results are compared with measurements to derive the optimum parameters for CFD/DEM simulations.The results suggest that the application of higher stiffness coefficients slightly improves the simulation accuracy.However,the average computing time increases exponentially.At larger fluid time steps,the results show that the average computation time is independent of the applied fluid time step whereas the simulation accuracy decreases greatly with increasing the fluid time step.The use of smaller time steps leads to negligible improvements in the simulation accuracy but results in an exponential rise in the average computing time.The parallelization accelerates the DEM simulations if the critical number for the domain decomposition is not reached.Above this number,the performance is no longer proportional to the number of processors.The critical number for the domain decomposition depends on the number of particles.An increase in solid contents results in a shift of the critical decomposition number to higher numbers of CPUs. | Falah Alobaid Nabil Baraki Bernd Epple | 2014 | Particuology2014，12，5： | 5 |
| 2 | Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin显示文摘For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune response.Flagellin is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical application.Calcium phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and proteins.Flagellin-functionalized calcium phosphate nanoparticles were prepared and their immunostimuiatory effect on the innate immune system,i.e.the cytokine production,was studied.They induced the production of the proinflammatory cytokines IL-8(Caco-2 cells) and IL-1β(bone marrow-derived macrophages;BMDM) in vitro and IL-6 in vivo after intraperitoneal injection in mice.The immunostimulation was more pronounced than with free flagellin. | Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer Astrid Maria Westendorf Matthias Epple Huimin Yan | 2014 | Virologica Sinica2014，29，1： | 3 |
| 3 | Improvement,validation and application of CFD/DEM model to dense gas-solid flow in a fluidized bed显示文摘Dense gas-solid flow with solid volume fraction greater than 10%and at moderate Reynolds number is important in many industrial facilities such as fluidized beds.In this work,the Euler-Lagrange approach in combination with a deterministic collision model is applied to a laboratory-scale fluidized bed.The fluid-particle interaction is studied using a new procedure called the offset method,which results in several numbers of spatial displacements of the fluid grid.The proposed method is highly precise in determining porosity and momentum transfer,thus improving simulation accuracy.A validation study was carried out to assess the results using this in-house CFD/DEM code against 5-s operation of a Plexiglas spouted-fluidized bed,showing good qualitative correlation of solid distribution in the bed and acceptable quantitative agreement of pressure drops at different positions in the bed.In view of high computing cost,special emphasis is placed on effective program design,such as application of advanced detection algorithm for particle-particle/wall collisions,the multi-grid method and parallel calculation.In this context,the influence of increasing the processor number,up to 36,on calculation efficiency was investigated. | Falah Alobaid Bernd Epple | 2013 | Particuology2013，11，5： | 3 |
| 4 | Grinding in an air classifier mill ( I ) : Characterisation of the one-phase flow 显示文摘 | Toneva P Epple P Breuer M Peukert W Wirth K | 2011 | Powder Technology2011，211，1： | 1 |
| 5 | Antagonistic control of oxidative stress induced cell death in Arabidopsis by two related,plant-specific zinc finger proteins显示文摘 | EPPLE P MACK A A | | 0，，： | 1 |
| 6 | The Persistence and Transfer of Learning in Industrial Settings显示文摘 | Argote L Beckman S L Epple D | 1990 | Management Science1990，36，： | 1 |
| 7 | Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol 显示文摘 | Epple H J Kreusel K M Hanski C | 1997 | Ptlugers Arch1997，433，5： | 1 |
| 8 | Impact of cadmium on the mummichog Fundulus heteroclitus and the role of cadmium in suppressing heavy metal toxicity 显示文摘 | GILL T S EPPLE A | 1992 | Comp Biochem Physiol C1992，101，3： | 1 |
| 9 | Functional y graded materials for biomedical applications显示文摘 | Pompe W Worch H Epple M | | 0，，： | 1 |
| 10 | Overview of legacy systems in L-band andits influence on the future aeronautical communication system L- DACSI显示文摘 | Survey on the future development for con- on Vehicular Tech Epple U Schnell M | 2014 | IEEE Aerospace and Electronic Magazine2014，29，2： | 1 |
| 11 | Overview of legacy systems in L-band and its influence on the future aeronautical communication system L-DACS1 显示文摘 | EPPLE U SCHNELL M | 2014 | IEEE Aerospace and Electronic Magazine2014，29，2： | 1 |
| 12 | Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusarium oxysporum显示文摘 | Epple P Apel K Bohlmann H | 1997 | Plant Cell1997，19，： | 1 |
| 13 | Continuous synthesis of amorphous carbonated apatites显示文摘 | Tadic D Peters F Epple MC | 2002 | Biomaterials2002，23，12： | 1 |
| 14 | EST sreveal a multigene family for plant defensins in Arabidopsis thalian显示文摘 | EPPLE P APEL K BRIEKAERT H | 1997 | FEBS Litt1997，400，： | 1 |
| 15 | Empirical validation of building energy simulation programs显示文摘 | Lomas K J Epple H Martin C | 1997 | Energy & Building1997，26，3： | 1 |
| 16 | Comparative analysis of costs of total intravenous anaesthesia with propofol and remifentanil vs balanted anaesthesia with isoflurane and fentany显示文摘 | Epple J Kuhitz J Schmidt H | 2001 | Eur J Anaesthesiol2001，18，： | 1 |
| 17 | 显示文摘 | Dorozhkin S V Epple M | 2002 | Angew Chem Int Ed2002，41，17： | 1 |
| 18 | Correlation of T cell responseand bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a based Salmonella vaccines 显示文摘 | Aebischer T Bumann D Epple HJ | 2008 | Gut2008，57，8： | 1 |
| 19 | Organi- zational Learning curves : A method for investigating intra - plant transfer of knowledge acquired through learning by doing 显示文摘 | Dennis Epple Linda Argote and Rukmin Devadas | 1991 | ORGANIZATION SCIENCE1991，2，： | 1 |
| 20 | Biomimetic crystallization of apatite in a porous polymer matrix显示文摘 | Karsten Schwarz Matthias Epple | 1998 | Chem Eur J1998，10，： | 1 |
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