|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 2 | Population-based study of DNA image cytometry as screening method for esophageal cancer显示文摘AIM:To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esopha-geal squamous precancerous lesions.METHODS:This study was designed as a population-based screening study.A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong.However,only 452 subjects had results of liquid-based cytology,DNA-ICM and pathology.The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.RESULTS:Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%,86.36%,79.55% and 77.27%,respectively,which were better than that of liquid-based cytology (75%).Specifici-ties of DNA-ICM were 70.83%,84.07%,92.65% and 96.81%,but the specificity of liquid-based cytology was 91.91%.The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%,respectively.CONCLUSION:It is possible to use DNA-ICM tech-nique as a primary screening method for esophageal squamous precancerous lesions. | Lin Zhao,Wen-Qiang Wei,Xin-Qing Li,Guo-Qing Wang,Qi Shang,You-Lin Qiao,Department of Cancer Epidemiology,Cancer Institute/Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China De-Li Zhao,Department of Epidemiology,Feicheng People’s Hospital,Feicheng 271600,Shandong Province,China Chang-Qing Hao,Department of Endoscopy,Linzhou Cancer Hospital,Linzhou 456500,Henan Province,China Dong-Mei Lin,Qin-Jing Pan,Department of Pathology,Cancer Institute/Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China Fu-Hua Lei,Department of Pathology,Feicheng People’s Hospi-tal,Feicheng 271600,Shandong Province,China Jin-Wu Wang,Department of Pathology,Linzhou Cancer Hospi-tal,Linzhou 456500,Henan Province,China | 2012 | World Journal of Gastroenterology2012，18，4： | 15 |
| 3 | 美蓝染色放大电子结肠镜观察结肠息肉与组织病理学的关系显示文摘目的:研究美蓝染色后用放大电子结肠镜观察结肠息肉的微细结构类型与组织病理学的关系。方法:使用0.5%美蓝对电子结肠镜检查到有息肉的部位进行息肉及邻近的黏膜进行染色,然后用放大电子结肠镜观察。按Kudo’s标准记录正常结肠黏膜和息肉,然后行活检或息肉电切术,以便组织病理学评价。结果:本组共67人,普通电子结肠镜检查发现息肉180颗,经美蓝染色后又发现了1-3mm大小的息肉90颗,共计270颗息肉。放大结肠镜可明显提高腺瘤性病变的检出率,P<0.001。270颗病变的隐窝类型分为6种,呈Ⅱ型者2颗(0.7%);Ⅲ_s型203颗(75.2%);Ⅲ_L型49颗(18.1%),其中伴有轻、中度非典型增生者7颗;Ⅳ型11颗(4.1%),伴有轻度非典型增生者2颗、黏膜癌1颗(9.1%),Ⅴ_n共5颗(1.9%),伴有中度非典型增生者1颗,黏膜癌2颗(40%)。本组息肉均进行了电切术。结论:美蓝染色后用放大电子结肠镜可清晰地观察到结肠隐窝,其大小一致,呈圆形或椭圆形;诊断为腺瘤性息肉与病理组织学的符合率为96.7%,可明显提高息肉的检出率,并可鉴别电切息肉术后残留的基底部是否残留腺瘤组织或癌灶。 | Lu Su Hong-Zhen Pan Jing-Biao Weng Yi-Hua Xu Fang Chen Mei-Yan Hong Department of Digestive Endoscopy, The Worker’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China | 2003 | 世界华人消化杂志2003，11，8： | 8 |
| 4 | Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMEDECCO consensus显示文摘 | Bourreille A Ignjatovic A Aabakken L World Organisation of Digestive Endoscopy (OMED) and the European Crohn's and Colitis Organisation (ECCO) | 2009 | Endoscopy2009，41，7： | 1 |
| 5 | Nonvariceal upper gastrointestinal haemorrhage:guidelines显示文摘 | British Society of Gastroenterology Endoscopy Committee | 2002 | Gut2002，51，4： | 1 |
| 6 | Endoscopy显示文摘 | Gay G Delvaux M Rey J E The role of video capsule endoscopy in the diagnosis of digestive diseases: a review of current possibilities | 2004 | Endoscopy2004，36，4： | 1 |
| 7 | Reprocessing of flexible gastrointestinal endoscopy显示文摘 | American Society for Gastrointestinal endoscopy | 1996 | Gastrointestinal endoscopy1996，43，5： | 1 |
| 8 | Nonvariceal upper gastrointestinal haemorrhage:guidelines显示文摘 | British Society of Gastroenterology Endoscopy Committee | 2002 | Gut2002，51，4： | 1 |
| 9 | Report of a working party of the British Society of Gastroentorology Endoscopy Committee 显示文摘 | Cleaning and disinfection of equipment for gastrointestinal endoscopy | 1998 | Gut1998，42，6： | 1 |
| 10 | Bowel preparation for colonoscopy:European Society of Gastrointestinal Endoscopy(ESGE) guideline显示文摘 | Hassan C Bretthauer M Kaminski MF European Society of Gastrointestinal Endoscopy | 2013 | Endoscopy2013，45，2： | 1 |
| 11 | Multisociety guideline on reprocessing flexible gas- trointestinal endoscopes: 2011 显示文摘 | ASGE Quality Assurance Ln Endoscopy Committee Petersen BT Chennat J | 2011 | Gastrointest Endose2011，73，6： | 1 |
| 12 | A consensus document on bowel preparation before colonoscopy:prepared by a task force from the American Society of Colon and Rectal Surgeons(ASCRS),the American Society for Gastrointestinal Endoscopy(ASGE),and the Society of American Gastrointestinal and Endoscopic Surgeons(SAGES)显示文摘 | Wexner SD Beck DE Baron TH American Society of Colon and Rectal Surgeons American Society for Gastrointestinal Endoscopy Society of American Gastrointestinal and Endoscopic Surgeons | 2006 | Gastrointest Endosc2006，63，7： | 1 |
| 13 | Non-variceal upper gastrointestinal haemorrhage:guidelines显示文摘 | British Society of Gastrointerology Endoscopy Committee | 2002 | Gut2002，51，4： | 1 |
| 14 | Proctoring and hospital endoscopy privileges显示文摘 | | 1991 | Gastrointest Endosc1991，37，： | 1 |
| 15 | Sedation and anesthesia in GI endoscopy显示文摘 | Standards of Practice Committee of the American Society forGastrointestinal Endoscopy Lichtenstein DR Jagannath S | | 0，，： | 1 |
| 16 | Principles of Training in Endoscopy显示文摘 | American Society for Gastrointestinal Endoscopy | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 17 | Tentative guidelines for endoscopic di- agnosis and treatment of varicosity and variceal bleeding in digestive tract(2009) 显示文摘 | Committee of esophageal varieosity Society of digestive Endoscopy of Chinese Medical Association | 2010 | Chin J Gig Endosc2010，27，1： | 1 |
| 18 | Reprocessing of flexible gastrointestinal Endoscopes显示文摘 | Members of the American Society for Gastrointestinal Endoscopy Ad Hoc Committee on Disinfection | 1996 | Gastrointest Endosc1996，43，： | 1 |
| 19 | Non-vat-iceal upper gastrointestinal haemorrhage : guidelines显示文摘 | British Society of Gastroenterology Endoscopy Committee | 2002 | Gut2002，51，4： | 1 |
| 20 | A consensus document on bowel preparation before colonoscopy: prepared by a Task Force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons ( SAGES ) 显示文摘 | American Society of Colon and Rectal Surgeons (ASCRS) American Society for Gastrointestinal Endoscopy ( ASGE ) Society of American Gastrointestinal and Endoscopic Surgeons ( SAGES) | 2006 | Surg Endosc2006，20，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员