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| 1 | Diagnostic non-invasive model of large risky esophageal varices in cirrhotic hepatitis C virus patients显示文摘AIM To build a diagnostic non-invasive model for screening of large varices in cirrhotic hepatitis C virus(HCV) patients. METHODS This study was conducted on 124 post-HCV cirrhotic patients presenting to the clinics of the Endemic Medicine Department at Mansoura University Hospital for evaluation before HCV antiviral therapy: 78 were Child A and 46 were Child B(score ≤ 8). Inclusion criteria for patients enrolled in this study was presence of cirrhotic HCV(diagnosed by either biopsy or fulfillment of clinical basis). Exclusion criteria consisted of patients with other etiologies of liver cirrhosis, e.g., hepatitis B virus and patients with high MELD score on transplant list. All patients were subjected to full medical record, full basic investigations, endoscopy, and computed tomography(CT), and then divided into groups with no varices, small varices, or large risky varices. In addition, values of Fibrosis-4 score(FIB-4), aminotransferase-to-platelet ratio index(APRI), and platelet count/splenic diameter ratio(PC/SD) were also calculated.RESULTS Detection of large varies is a multi-factorial process, affected by many variables. Choosing binary logistic regression, dependent factors were either large or small varices while independent factors included CT variables such coronary vein diameter, portal vein(PV) diameter, lieno-renal shunt and other laboratory noninvasive variables namely FIB-4, APRI, and platelet count/splenic diameter. Receiver operating characteristic(ROC) curve was plotted to determine the accuracy of non-invasive parameters for predicting the presence of large esophageal varices and the area under the ROC curve for each one of these parameters was obtained. A model was established and the best model for prediction of large risky esophageal varices used both PC/SD and PV diameter(75% accuracy), while the logistic model equation was shown to be(PV diameter ×-0.256) plus(PC/SD ×-0.006) plus(8.155). Values nearing 2 or more denote large varices.CONCLUSION This model equation has 86.9% sensitivity and 57.1% specificity, and would be of clinical applicability with 75% accuracy. | Hatem Elalfy Walid Elsherbiny Ashraf Abdel Rahman Dina Elhammady Shaker Wagih Shaltout Ayman Z Elsamanoudy Bassem El Deek | 2016 | World Journal of Hepatology2016，8，24： | 5 |
| 2 | Is toxoplasmosis a potential risk factor for liver cirrhosis?显示文摘Objective:To document Toxoplasma gondii(T.gondii) antibody status in patients with liver disease,blood samples were taken from 180 hepatic patients and 180 healthy controls.Methods:Toxoplasma IgG antibody was detected using enzyme-linked immunosorbent assay and histopathological assessment of liver biopsy METAVIR score was applied.Results:Anti-T.gondii IgG antibodies were found in 32.8%of patients and in 22.2%of controls(P=0.02).Toxoplasma seropositivity was significantly associated with lymphadenopathy,history of blood transfusion and reflex impairment in patients.Chronic hepatitis C virus(HCV)and chronic HCV-related cirrhosis groups compared to chronic HBV and chronic HBV-related cirrhosis groups expressed significantly higher prevalence of T.gondii seropositivity(odds ratio(OR) =4;95%confidence interval(CI):1.3-12.6;P=0.013,OR=4.8;95%CI:1.5-14.9;P=0.006,respectively).Within the chronic HCV group,T.gondii seropositivity significantly associated disease evolution as regards to METAVIR histopathological system for fibrosis and inflammation(OR=19.4;95%CI:2.3-165.2;P=0.0008,OR=0.29;95%CI:0.1-0.8;P=0.01,respectively).Albumin,international normalized ratio(INR) and platelets count were the laboratory parameters significantly altered in Toxoplasma-positrvc chronic HCV patients(P=0.00 l,0.03,0.04,respectively).Child-Pugh scoring for cirrhosis in chronic HCV group placed the majority of seropositive patient in class C with significant statistical difference compared to Child A reference group(OR= 0.08;95%67:0.01-0.5;P=0.003).Conclusions:Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution,suggesting that cirrhotic patients may thus form a risk group for toxoplasmosis. | Abeer Abd El-Rehim El-Henawy Ahmed Abdel-Razik Sahar Zakaria Dina Elhammady Niveen Saudy Manar Sobh Azab | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 4 |
| 3 | Interrelationship between Toll-like receptors and infection after orthotopic liver transplantation显示文摘Early microbial recognition by the innate immune system is accomplished by Toll-like receptors(TLRs),with resultant initiation of a pro-inflammatory response against infecting organisms.In spite of presence of an abundance of Toll-like receptors on the surface of the liver,gut bacteria does not elicit an inflammatory reaction in healthy individuals due to tolerance to these TLRs,suggesting that the inflammatory responses seen in the liver are the result of breakdown of this tolerance.While orthotopic liver transplantation is often life saving in many instances,death following this procedure is most commonly due to infection that occurs in up to 80%of transplant recipients,most commonly due to microbial causes in up to 70%of cases and viral infections in 20%,while fungal infections affect only 8%of cases.The probability of acquiring infection following hepatic transplantation is heightened due to affection of the innate immune defense mechanisms of the host following this procedure.Single nucleotide polymorphisms of TLRs have been associated with increased likelihood of either development of post-transplant infection or eradication of infecting organism.However,conflicting reports from other studies reveal that prevalence of this single nucleotide polymorphism is not increased in infected patients. | Mahmoud El-Bendary Mustafa Naemattalah Ahmed Yassen Naser Mousa Dina Elhammady Ahmed M Sultan Mohamed Abdel-Wahab | 2020 | World Journal of Transplantation2020，10，6： | 3 |
| 4 | Selective ophthalmic artery infusion of chemotherapy for advanced intrao- cular retinoblastoma: initial experience with 17 tumors显示文摘 | Petersou EC Elhammady MS Quintero-Wolfe S | 2011 | J Neurosurg2011，114，： | 1 |
| 5 | Cervical sub arachnoid catheter placement for continuous cerebrospinal flu iddrainage: a safe and efficacious alternative to the classic lure bar cisterndrian 显示文摘 | Farhat HI Elhammady MS Lenvi AD | 2011 | Neurosurgrey2011，68，1： | 1 |
| 6 | Minimally invasive anterolateral approaches for the treatment of back pain and adult degenerative deformity显示文摘 | Benglis DM Elhammady MS Levi AD | 2008 | Neurosurgery2008，63，3： | 1 |
| 7 | Effect of oxidized regenerated cellulose (Interceed) on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells显示文摘 | Gago LA Saed G Elhammady E | | 0，，4： | 1 |
| 8 | Effect of oxidized regenerated cellulose(interceed)on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells显示文摘 | Gago LA Saed G Elhammady E | 2006 | Fertil Steril2006，86，4： | 1 |
| 9 | Programme for improving emotional and cognitive changes in patients under renal dialysis in Egypt显示文摘 | Awadalla H I El--Ateek A M Elhammady M M | 2008 | East Mediterr Health J2008，14，3： | 1 |
| 10 | Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum显示文摘 | Freeman ML Saed GM Elhammady EF | 2003 | Fertil Steril2003，80，2： | 1 |
| 11 | Effect of oxidized regenerated cellulose(Interceed)on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells显示文摘 | GAGO L A SAED G ELHAMMADY E | 2006 | Fertil Steril2006，86，4： | 1 |
| 12 | Endoscopic fenestra- tion of middle fossa arachnoid cysts: a technical description and case series 显示文摘 | Elhammady MS Bhatia S Ragheb J | 2007 | Pediatr Neurosurg2007，43，3： | 1 |
| 13 | Endoscopic fen- estration of middle fossa araehnoid cysts: a technical description and case series显示文摘 | ELHAMMADY M S BHATIA S RAGHEB J | 2007 | Pediatr Neurosurg2007，43，3： | 1 |
| 14 | Onyx embolization of carotid-cavernous fistulas显示文摘 | Elhammady MS Wolfe SQ Farhat H | 2010 | Neurosurgery2010，112，： | 1 |
| 15 | Onyx embolization of carotid-cavernous fistulas: Clinical article显示文摘 | Elhammady M S Wolfe S Q Farhat H | 2010 | J Neurosurg2010，112，3： | 1 |
| 16 | Onyx embolizationof carotid-cavernous fistulas 显示文摘 | Elhammady MS Wolfe SQ Farhat H | 2010 | J Neurosurg2010，112，3： | 1 |
| 17 | Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjur ed peritoneum显示文摘 | Freeman ML Saed GM Elhammady EF | | 0，，2： | 1 |
| 18 | Expres sion of transforming growth factor beta is oform mRNA in in jured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum显示文摘 | Freeman ML Saed GM Elhammady EF | 2003 | Fertil Steril2003，80，2： | 1 |
| 19 | Selective ophthalmic artery infusion of chemotherapy foradvanced intraocular retinoblastoma:initial experience with17 tumors显示文摘 | Peterson EC Elhammady MS Quintero-Wolfe S | 2011 | Neurosurg2011，114，6： | 1 |
| 20 | Altered fatty acid profile of polar lipids in maize seedlings in response to excess copper显示文摘 | Chaffai R Elhammadi M A Seybou T N | 2007 | J Agron Crop Sci2007，193，： | 1 |
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