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| 1 | Oxidative and nitrosative stress enzymes in relation to nitrotyrosine in Helicobacter pylori-infected humans显示文摘AIM: To compare a possible relation between Helicobacter pylori(H. pylori) and the oxygen- and nitrogen radical system in humans. METHODS: Mechanisms for H. pylori to interfere with the oxygen and nitrogen radical system is of great importance for understanding of the H. pylori persistence and pathogenesis. Biopsies were obtained from the gastric wall of 21 individuals. Ongoing infection with H. pylori was detected using direct analyze from the biopsies using campylobacter-like organism test(CLO-test) and/or by using 14C-urea breath test. The individuals were divided in a negative H. pylori and a positive H. pylori group. Expression in the gastric mucosa of induc-ible nitric oxide syntase(iNOS), nicotinamide adenine dinucleotide phosphate-oxidase(NADPH-oxidase) myeloperoxidase(MPO), and nitrotyrosine were assessed by Western blotting.RESULTS: The individuals who undervent gastroscopy were divided in a H. pylori neg. [n = 13, m/f = 7/6, age(mean) = 39] and a H. pylori pos. group [n = 8, m/f = 5/3, age(mean) = 53]. Using western blot analysis iNOS was detected as a 130 kDa band. The iNOS expression was upregulated in the antrum of H. pylori infected individuals in comparison to the controls, mean ± SD being 12.6 ± 2.4 vs 8.3 ± 3.1, P < 0.01. There was a markedly upregulated expression of MPO in the antrum of H. pylori infected individuals in comparison to the control group without infection. In several of noninfected controls it was not possible to detect any MPO expression at all, whereas the expression was high in all the infected subjects, mean ± SD being 5.1 ± 3.4 vs 2.1 ± 1.9, P < 0.05. The NADPH-oxidase expression was analysed by detecting the NADPH-oxidase subunit p47-phox expression. P47-phox was detected as a 47 kDa band using Western blot, and showed a significantly higher expression of p47-phox in the antrum of the H. pylori infected individuals compared to the controls, mean ± SD being 3.1 ± 2.2 vs 0.3 ± 0.2, P < 0.01. Regarding nitrotyrosine formation, Western blot did not show any significant increase or decrease compared to controls, 7.0 ± 0.9 vs 6.9 ± 1.1, not significant.CONCLUSION: iNOS, MPO and NADPH-oxidase was up-regulated among H. pylori infected. Regarding nitrotyrosine no difference was found. This support an H. pylori related inhibition of radical formation. | Anders Elfvin Anders Edebo Peter Hallersund Anna Casselbrant Lars Fndriks | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 5 |
| 2 | Low birthweight, gestational age, need for surgical intervention and gram-negative bacteraemia predict intestinal failure following necrotising enterocolitis显示文摘 | Elfvin A Dinsdale E Wales PW | 2015 | Acta Paediatr2015，100，8： | 1 |
| 3 | Primary sensory afferents in the thymus of the guinea pig demonstrated with anterogradely transported horseradish peroxidase conjugates显示文摘 | | 1993 | Neurosci Lett1993，5，1： | 1 |
| 4 | Paramyosin in invertebrate muscles显示文摘 | ELFVIN M LECINE R J DEWEY M M | 1976 | Cell Biol1976，71，1： | 1 |
| 5 | A study of the extrinsic innervation of the guinea pig pylorus with the horseradish peroxidase tracing technique显示文摘 | Elfvin LG Lindh B | 1982 | J Comp Neurol1982，208，： | 1 |
| 6 | Breast feeding in women with type 1 diabetes:exploration of predictive factors显示文摘 | Sparud-Lundin C Wennergren M Elfvin A | | 0，，02： | 1 |
| 7 | Primary sensory afferents in the thymus of the guinea pig demonstrated with anterogradely transported horseradish peroxidase conjugates显示文摘 | Elfvin LG | 1993 | Neurosci Lett1993，5，1： | 1 |
| 8 | Effects of peripheral axotomy on neuropeptides and nitric oxide synthase in dorsal root ganglia and spinal cord of the guinea pig:an immunohistochemical study 显示文摘 | Rydh Rinder M Holmberg K Elfvin L G | 1996 | Brain Res1996，707，2： | 1 |
| 9 | Quantitative measurement of nitric oxide and hydrogen peroxide in HeIieobacter pylorV infected Mongolian gerbils in vivo显示文摘 | Elfvin A Edebo A B61in I | 2007 | Scandinavian Journal of Gastroenterology2007，42，10： | 1 |
| 10 | Paramyosin in invertebrate muscles显示文摘 | ELFVIN M LEVINE RJC DEWEY MM | 1976 | J Cell Biol1976，71，： | 1 |
| 11 | Paramyosin in invertebrate muscle identification and localization显示文摘 | Elfvin M Levine R J C Dewey M M | 1976 | Journal of Cell Biology1976，71，： | 1 |
| 12 | Primary sensory afferents in the thymus of the guineapig demonstrated with anterogradely transported horseradish peroxidase conjugates显示文摘 | Elfvin LG | 1993 | Neurosci Lett1993，5，1： | 1 |
| 13 | The expression of renin-angiotensin system components in the human gastric mucosa 显示文摘 | Hallersund P Elfvin A Helander HF | 2011 | J Renin Angioten- sin Aldosterone Syst2011，12，1： | 1 |
| 14 | Quantitative measurement of nitric oxide and hydrogen peroxide in Helicobacter pylori -infected Mongolian gerbils in vivo显示文摘 | Anders Elfvin Anders Edebo Ingrid B?lin Lars F?ndriks | 2007 | Scandinavian Journal of Gastroenterology2007，，10： | 1 |
| 15 | The expres- sion of renin-angiotensin system components in the hu- man gastric mucosa显示文摘 | Hallersund P Elfvin A Helander HF | 2011 | J Renin Angiotensin Aldosterone Syst2011，12，1： | 1 |
| 16 | The expression of renin-angiotensin system components in the human gastric mucosa显示文摘 | Hallersund P Elfvin A Helander HF | 2011 | J Renin Angiotensin Aldosterone Syst2011，12，： | 1 |
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