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| 1 | Oxidative and nitrosative stress enzymes in relation to nitrotyrosine in Helicobacter pylori-infected humans显示文摘AIM: To compare a possible relation between Helicobacter pylori(H. pylori) and the oxygen- and nitrogen radical system in humans. METHODS: Mechanisms for H. pylori to interfere with the oxygen and nitrogen radical system is of great importance for understanding of the H. pylori persistence and pathogenesis. Biopsies were obtained from the gastric wall of 21 individuals. Ongoing infection with H. pylori was detected using direct analyze from the biopsies using campylobacter-like organism test(CLO-test) and/or by using 14C-urea breath test. The individuals were divided in a negative H. pylori and a positive H. pylori group. Expression in the gastric mucosa of induc-ible nitric oxide syntase(iNOS), nicotinamide adenine dinucleotide phosphate-oxidase(NADPH-oxidase) myeloperoxidase(MPO), and nitrotyrosine were assessed by Western blotting.RESULTS: The individuals who undervent gastroscopy were divided in a H. pylori neg. [n = 13, m/f = 7/6, age(mean) = 39] and a H. pylori pos. group [n = 8, m/f = 5/3, age(mean) = 53]. Using western blot analysis iNOS was detected as a 130 kDa band. The iNOS expression was upregulated in the antrum of H. pylori infected individuals in comparison to the controls, mean ± SD being 12.6 ± 2.4 vs 8.3 ± 3.1, P < 0.01. There was a markedly upregulated expression of MPO in the antrum of H. pylori infected individuals in comparison to the control group without infection. In several of noninfected controls it was not possible to detect any MPO expression at all, whereas the expression was high in all the infected subjects, mean ± SD being 5.1 ± 3.4 vs 2.1 ± 1.9, P < 0.05. The NADPH-oxidase expression was analysed by detecting the NADPH-oxidase subunit p47-phox expression. P47-phox was detected as a 47 kDa band using Western blot, and showed a significantly higher expression of p47-phox in the antrum of the H. pylori infected individuals compared to the controls, mean ± SD being 3.1 ± 2.2 vs 0.3 ± 0.2, P < 0.01. Regarding nitrotyrosine formation, Western blot did not show any significant increase or decrease compared to controls, 7.0 ± 0.9 vs 6.9 ± 1.1, not significant.CONCLUSION: iNOS, MPO and NADPH-oxidase was up-regulated among H. pylori infected. Regarding nitrotyrosine no difference was found. This support an H. pylori related inhibition of radical formation. | Anders Elfvin Anders Edebo Peter Hallersund Anna Casselbrant Lars Fndriks | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 5 |
| 2 | Expression of protease-activated- receptor 2 (PAR-2) in human esophageal mucosa显示文摘 | Inci K Edebo A Olbe L | 2009 | Scand J Gastroenterol2009，44，6： | 1 |
| 3 | Decreased Epi thelial Cytokine Responses in the Duodenal Mucosa of Helicobacter pylori-Infected Duodenal Ulcer Patients显示文摘 | Stromberg E Edebo A Svennerholm A M | 2003 | Clinical And Diag nostic Laboratory Immunology2003，10，1： | 1 |
| 4 | Performance of Rhizopus,Rhizomucor,and Mucor in ethanol production from glucose,xylose,and wood hydrolyzates显示文摘 | Millati R Edebo L and Taherzadeh M J | 2004 | Enzyme and Microbid Technology2004，，23： | 1 |
| 5 | Ethanol production from hexoscs,pentoses,and dilute-acid hydrolyzate by Mucor indicus显示文摘 | Sues A Millati R Edebo L and Taherzadeh M J | 2005 | FEMS Yeast Research2005，，67： | 1 |
| 6 | Esophageal barrier function and tight junction expression in healthy subjects and patients with gas- troesophageal reflux disease: functionality of esophageal mucosa ex-posed to bile salt and trypsin in vitro 显示文摘 | Bjorkman E V Edebo A Oltean M | 2013 | Stand J Gastroenterol2013，48，10： | 1 |
| 7 | A novel monoclonal antibody recognizing 13 ( 1-3 ) glucans in intact ceils of Candida and Cryptococcus显示文摘 | Kondori N Edebo L Mattsby-Bahzer I | 2008 | APMIS2008，116，10： | 1 |
| 8 | Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro 显示文摘 | Bj6rkman E Edebo A Oltean M | 2013 | Scand J Gastroenterol2013，48，10： | 1 |
| 9 | Quantitative measurement of nitric oxide and hydrogen peroxide in HeIieobacter pylorV infected Mongolian gerbils in vivo显示文摘 | Elfvin A Edebo A B61in I | 2007 | Scandinavian Journal of Gastroenterology2007，42，10： | 1 |
| 10 | Extraction and precipitation of chitosan from cell wall of Zygomycetes fungi by dilute sulfuric acid显示文摘 | Zamani A Edebo L Sjostrom B | 2007 | Biomacromolecules2007，8，12： | 1 |
| 11 | Magnification endoscopy for diagnosis of nonerosive reflux disease: a proposal of diagnostic criteria and critical analysis of observer variability显示文摘 | A. Edebo W. Tam M. Bruno A.-M. Van Berkel C. J?nson M. Schoeman G. Tytgat J. Dent L. Lundell | 2007 | Endoscopy2007，，03： | 1 |
| 12 | Expression of protease-activa- ted-receptor2 (PAR-2) in human esophageal mucosa 显示文摘 | Inci K Edebo A Olbe L | 2009 | Scand J Gastroenterol2009，44，6： | 1 |
| 13 | Expression of proteaseactivated-receptor 2(PAR-2)in human esophageal mucosa显示文摘 | Inci K Edebo A Olbe L | | 0，，06： | 1 |
| 14 | Expression of protease- activated-receptor 2 (PAR-2) in human esophageal mucosa 显示文摘 | Inci K Edebo A Olbe L | 2009 | Scand J Gastroenterol2009，44，6： | 1 |
| 15 | Comparison of different routes of vaccination for eliciting antibody responses in the human stomach显示文摘 | Johansson EL Bergquist C Edebo A | 2004 | Vaccine2004，22，： | 1 |
| 16 | Ethanol production from hexoses,pentoses,and dilute-acid hydrolyzate by Mucor indicus显示文摘 | Sues A Millati R Edebo L Taherzadeh M J | | 0，，6： | 1 |
| 17 | Performance of Rhizopus,Rhizomucor,and Mucor in ethanol production from glucose,xylose,and wood hydrolyzates显示文摘 | Millati R Edebo L Taherzadeh M J | | 0，，2： | 1 |
| 18 | Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro 显示文摘 | Bjorkman EV Edebo A Ohean M | 2013 | Scand J Gastroenterol2013，48，10： | 1 |
| 19 | Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease:functionality of esophageal mucosa exposed to bile salt and trypsin in vitro显示文摘 | Bjrkman EV Edebo A Oltean M | 2013 | Scand J Gastroenterol2013，48，10： | 1 |
| 20 | Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease:functionality of esophageal mucosa exposed to bile salt and trypsin in vitro显示文摘 | Bjo rkman EV Edebo A Oltean M | | 0，，10： | 1 |
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