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| 1 | Comparison of one and three initial monthly intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion显示文摘AIM: To compare three initial monthly intravitreal ranibizumab(IVR) injections followed by pro re nata(PRN) dosing with one initial monthly IVR injections followed by PRN dosing for macular edema(ME) secondary to branch retinal vein occlusion(BRVO).METHODS: Forty-two eyes of 42 patients who had IVR injections for BRVO were retrospectively studied. Eighteen eyes received 1 initial IVR injection(1+PRN group) and 24 eyes received 3 monthly IVR injections(3+PRN). At 1, 3, 6 and 12mo; spectral-domain optical coherence tomography(SD-OCT) was performed. Central macular thickness(CMT), the integrity of the external limiting membrane(ELM), the presence of subretinal fluid, cyst size, the presence of inner segment/outer segment(IS/OS) defect were determined.RESULTS: At baseline the mean CMT was 521.3±153.2 μm in the 3+PRN group while it was 438.1±162.4 μm in 1+PRN group. At the final visit, mean CMT was 278.3±87.8 μm in the 3+PRN group and 285.2±74.2 μm in the 1+PRN group(P=0.079). The changes in CMT over the entire study period were also comparable in both groups(243±160 μm in the 3+PRN group, and 152.9±175.3 μm in the 1+PRN group; P=0.090). At baseline, best-corrected visual acuity(BCVA) was 0.92±0.60 logarithm of the minimal angle of resolution(logMAR) in the 3+PRN group, while it was 0.72±0.46 logMAR in the 1+PRN group. Final BCVA was 0.42±0.55 logMAR in the 3+PRN group and 0.38±0.50 logMAR in the 1+PRN group(P=0.979). Additionally, the BCVA changes from baseline to final visit were not significantly different(-0.50±0.45 logMAR in the 3+PRN group, and-0.33±0.39 logMAR in the 1+PRN group; P=0.255).CONCLUSION: No significant differences in the anatomical or functional results are found between 3+PRN and 1+PRN regimens in the patients receiving ranibizumab for ME secondary to BRVO. Intact IS/OS and baseline BCVA are good predictor of the visual gain, while baseline CMT is a good predictor of the anatomical gain. | Alper Halil Bayat Akin Cakir Seyma Gülcenur Ozturan Selim Bolükbasi Burak Erden Mustafa Nuri Elcioglu | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 6 |
| 2 | 比较雷珠单抗和贝伐珠单抗对新生血管AMD的疗效(英文)显示文摘目的:比较玻璃体内注射雷珠单抗与贝伐珠单抗对年龄相关性黄斑变性(age-related macular degeneration,AMD)的疗效,治疗方案必要时采用。方法:回顾性分析63例63眼(雷珠单抗治疗组35眼,贝伐珠单抗治疗组28眼)新确诊新生血管年龄相关性黄斑变性患者的资料。治疗12mo后随访,分析比较两组患者的最佳矫正视力(BCVA)和黄斑中心凹厚度(CFT)。采用双尾t检验和单因素方差分析比较两组最佳矫正视力和黄斑中心凹厚度的变化。结果:雷珠单抗治疗组35眼和贝伐珠单抗治疗组28眼均完成12mo随访,并记录数据。雷珠单抗治疗组最佳矫正视力均值增加0.1logMAR;相反,贝伐珠单抗治疗组最佳矫正视力均值下降0.06logMAR(P=0.01)。雷珠单抗治疗组13眼(37%)和贝伐珠单抗治疗组4眼(14%)最佳矫正视力至少增加0.3logMAR。雷珠单抗治疗组平均黄斑中心凹厚度减少41.6μm,贝伐珠单抗治疗组减少8.1μm(P=0.003)。两组平均注射次数是4.46次和4.11次(P>0.05)。结论:玻璃体内注射雷珠单抗组在视力和消水肿方面疗效优于贝伐珠单抗组。但是,两种药的疗效和安全性还需要随机的长期临床试验来验证。 | Huseyin Serdarogullari Muzaffer Ozturk Umur Kayhan Selim Bolukbasi Burak Erden Mustafa Elcioglu | 2014 | 国际眼科杂志2014，14，5： | 2 |
| 3 | Severe thrombocytopenia and alveolar hemorrhage represent two types of bleeding tendency during tirofiban treatment:Case report and literature review显示文摘 | ELCIOGLU O C OZKOK A AKPINAR T S | 2012 | Int J Hematol2012，96，： | 1 |
| 4 | Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease显示文摘 | Abdullah Ozkok Omer Celal Elcioglu Tahsin Cukadar Ali Bakan Gulsah Sasak Kadir Gokhan Atilgan Sabahat Alisir Mehmet Kanbay Adrian Covic Ali Riza Odabas | 2013 | International Urology and Nephrology2013，，2： | 1 |
| 5 | New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey显示文摘 | Beales PL Elcioglu N Woolf AS | 1999 | J Med Genet1999，36，6： | 1 |
| 6 | Hyperuricemia is associated with progression of IgA nephropathy显示文摘 | Bakan A Oral A Elcioglu OC | 2015 | Int Urol Nephrol2015，47，4： | 1 |
| 7 | New criteria for improved diagnosis of Bardet - Biedl syndrome : Results of a population survey显示文摘 | Beales PL Elcioglu N Woolf AS | 1999 | J Med Genet1999，36，6： | 1 |
| 8 | Crescentic glomerulonephritis due to IgA nephropathy or propylthiouracilinduced Mpo - Anca positive vasculitis?显示文摘 | Ozkok A Makbule Sirin B Celal Elcioglu 0 | 2013 | Ren Fail2013，35，6： | 1 |
| 9 | Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition-inflammation-atherosclerosis syndrome in patients with chronic kidney disease显示文摘 | Ozkok A Elcioglu OC Cukadar T | 2013 | Int Urol Nephrol2013，45，2： | 1 |
| 10 | Severe throm-bocytopenia and alveolar hemorrhage represent two typesof bleeding tendency during tirofiban treatment : case re-port and literature review显示文摘 | Elcioglu OC Ozkok A Akplnar TS | 2012 | Int J Hematol2012，96，3： | 1 |
| 11 | New criteria for improved diagnosis of Bardet-Biedl syndrome:results of a population survey显示文摘 | Beales PL Elcioglu N Woolf AS | 1999 | J Med Genet1999，36，： | 1 |
| 12 | Hyperuricemia is associated with progression of lgA nephropathy显示文摘 | Bakan A Oral A Elcioglu OC | 2015 | Int Urol Nephrol2015，47，4： | 1 |
| 13 | Severethrombocytopenia and alveolar hemorrhage represent twotypes of bleeding tendency during tirofiban treatment: casereport and literature review显示文摘 | Elcioglu OC Ozkok A Akpinar TS | 2012 | Int J Hematol2012，96，3： | 1 |
| 14 | Urinary bladder stone extraction and instruments compared in textbooks of Abul- Qasim Khalaf Ibn Abbas Alzahrawi (Albucasis) (930-1013) and Serefeddin Sabuncuoglu (1385-1470) 显示文摘 | ELCIOGLU O OZDEN H GUVEN G | 2010 | J Endourol2010，24，9： | 1 |
| 15 | New criteria for improved diagnosis of Bardet-Biedl syndrome : results of a population survey显示文摘 | Beales PL Elcioglu N Woolf AS Parker 1) Flinter FA | 1999 | J Med Genet1999，36，6： | 1 |
| 16 | Renalase: Another puzzle piece between hypertension and simple renal cysts显示文摘 | Elcioglu OC Afsar B Takir M | 2015 | lnt Urol Neph- rol2015，47，7： | 1 |
| 17 | A Rapp-Hodgkin like syndrome in three sibs: clinical, dental and dermatoglyphic study显示文摘 | Atasu M Akesi S Elcioglu N | 1999 | Clin Dysmorphol1999，8，2： | 1 |
| 18 | Molecular diagnosis of oculocutaneous albinism:new mutations in the OCA1-4genes and practical aspects显示文摘 | Rooryck C Morice-Picard F Elcioglu NH | 2008 | Pigment Cell Melanoma Res2008，21，5： | 1 |
| 19 | Common THoughts of Socrates and Yusuf Khass Hajib on WIsdom and VIrtue显示文摘 | Elcioglu Omur& Ozden Hilmi | 2004 | JISHIM2004，，3： | 1 |
| 20 | Severe thrombocytopenia and alveolar hemorrhage represent two types of bleeding tendency during tirofibantreatment:case report and literature review显示文摘 | Elcioglu OC Ozkok A Akpinar TS | 2012 | Hematol2012，96，3： | 1 |
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