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| 1 | Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats显示文摘Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury(SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein(GFAP) and S100 calcium-binding protein B(S100B)(astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats(aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases(first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. | Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da Silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier Carlos Alberto Saraiva Goncalves Carlos Alexandre Netto Regis Gemerasca Mestriner | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 2 | Coordinated control of cell Ca2 + loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-Typo Ca2 + current显示文摘 | Trafford AW Diaz ME Eisner DA | 2001 | Circ Res2001，88，： | 1 |
| 3 | Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess 显示文摘 | Eisner JR Barnett MA Dumesic DA | 2002 | Fertil Stefil2002，77，1： | 1 |
| 4 | The control of Ca^2+ release from the sarcoplasmic reticulum: regulation versus autoregulation显示文摘 | Eisner DA Trafford AW Diaz ME | 1998 | Cardiovasc Res1998，74，： | 1 |
| 5 | Sarcoplasmic reticulum calcium fluctuation is the key to cardiac alternans显示文摘 | Diaz ME Neill SCO Eisner DA | 2004 | Circ Res2004，94，： | 1 |
| 6 | Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess显示文摘 | Eisner JR Barnett MA Dumesic DA | 2002 | Fertil Steril2002，77，： | 1 |
| 7 | The effects of membrane potential,SR Ca^2+ content and RyR responsiveness on systolic Ca^2+ ahemans in rat ventricular myocytes 显示文摘 | Li Y Diaz ME Eisner DA | 2009 | J Physiol2009，587，6： | 1 |
| 8 | A mechanism for the effects of caffeine on Ca2+release during diastole and systole in isolated rat ventricular myocytes 显示文摘 | 8,O′Neill Eisner DA | 1990 | JPhysiol1990，430，： | 1 |
| 9 | Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition显示文摘 | Overend CL Eisner DA O Neill SC | 2001 | Circ Res2001，88，2： | 1 |
| 10 | The control of Ca release from the sarcoplasmic reticulum: regulation versus autoregulation显示文摘 | Eisner DA Trafford AW Diaz ME | 1998 | Cardiovasc Res1998，38，： | 1 |
| 11 | What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis显示文摘 | Eisner DA Kashimura T | 2009 | J Mol Cell Cardiol2009，46，4： | 1 |
| 12 | Increased adiposity infemale rhesusmonkeys exposed to androgen excess during early gestation显示文摘 | Eisner JR Dumesic DA Kemnitz JW | 2003 | ObesityResearch2003，11，： | 1 |
| 13 | Oscillations of intracellular Ca2+ in mammalian cardiac muscle显示文摘 | Orchard CH Eisner DA Allen DG | 1983 | Nature1983，304，5928： | 1 |
| 14 | Regulation of intracellular and mitochondrial sodium in health and disease 显示文摘 | Murphy E Eisner DA | 2009 | Circ Res2009，104，3： | 1 |
| 15 | Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys 显示文摘 | Eisner JR Dumesic DA Kemnitz JW Abbott dh | 2000 | Clin Endocrinal Metab2000，85，： | 1 |
| 16 | Sarcoplasmic reticulum calcium con- tent fluctuation is the key to cardiac altemans 显示文摘 | Diaz ME OcNeill SC Eisner DA | 2004 | Circ Res2004，94，11： | 1 |
| 17 | Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess显示文摘 | Eisner JR Barnett MA Dumesic DA | 2002 | Fertil Steril2002，77，1： | 1 |
| 18 | Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans显示文摘 | Diaz ME ONeill SC Eisner DA | 2004 | Circ Res2004，94，5： | 1 |
| 19 | Sarcoplasmic reticulum Ca^2 + and heart failure :roles of diastolic leak and Ca^2 + transport 显示文摘 | Bets DM Eisner DA Valdivia HH | 2003 | Circ Res2003，93，6： | 1 |
| 20 | Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes显示文摘 | Diaz ME Eisner DA ONeill SC | 2002 | Circ Res2002，91，7： | 1 |
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