|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pentoxifylline in hepatopulmonary syndrome显示文摘AIM:To determine the effects of pentoxifylline(PTX) on clinical manifestations and evaluate arterial blood gas data in hepatopulmonary syndrome(HPS) in children.METHODS:In a pilot study of 10 children with chronic liver disease,who had HPS,20 mg/kg/d PTX was administered for 3 mo.Clinical data and arterial blood gas parameters were evaluated at baseline,the end of the treatment period,and 3 mo after drug discontinuation.RESULTS:Six patients could tolerate PTX,while four patients experienced complications.Among patients who could tolerate PTX,there was a significant increase in arterial oxygen pressure(PaO 2)(P = 0.02) and oxygen saturation(SaO 2)(P = 0.04) and alveolar-arterial oxygen gradient(P = 0.02) after 3 mo of treatment.Significant decreases in PaO 2(P = 0.02) and alveolararterial oxygen gradient(P = 0.02) were also seen after drug discontinuation.CONCLUSION:PTX may improve PaO 2,SaO 2 and alveolar-arterial oxygen gradient in the early stage of HPS. | Hamid Reza Kianifar Maryam Khalesi Eftekhar Mahmoodi Monavar Afzal Aghaei | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 2 | Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of microribonucleic acids显示文摘5-flurouracil(5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer(CRC).Despite significant progress in the treatment of CRC during the last decades,5-FU drug resistance remains the most important cause of failure in CRC therapy.Resistance to 5-FU is a complex and multistep process.Different mechanisms including microsatellite instability,increased expression level of key enzyme thymidylate synthase and its polymorphism,increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells.Recently,microribonucleic acids(miRNA)and their alterations were found to have a crucial role in 5-FU resistance.In this regard,the miRNA-mediated mechanisms of 5-FU drug resistance reside among the new fields of pharmacogenetics of CRC drug response that has not been completely discovered.Identification of the biological markers that are related to response to 5-FU-based chemotherapy is an emerging field of precision medicine.This approach will have an important role in defining those patients who are most likely to benefit from 5-FU-based chemotherapy in the future.Thereby,the identification of 5-FU drug resistance mechanisms is an essential step to predict and eventually overcome resistance.In the present comprehensive review,we will summarize the latest knowledge regarding the molecular determinants of response to 5-FU-based chemotherapy in CRC by emphasizing the role of miRNAs. | Amirsaeed Sabeti Aghabozorgi Mostafa Moradi Sarabi Reza Jafarzadeh-Esfehani Shabnaz Koochakkhani Marziyeh Hassanzadeh Soudabeh Kavousipour Ebrahim Eftekhar | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 3 |
| 3 | Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: Results of a colonoscopy based study显示文摘AIM: To estimate the prevalence of colorectal cancer (CRC) in patients with long lasting colonic symptoms undergoing total colonoscopy; and to establish clinical features predicting its occurrence. METHODS: This prospective study was carried out in Imam Hospital, Tabriz University of medical sciences, Iran. Continuous patients with long lasting lower gastrointestinal tract symptoms who had the criteria of a colonoscopy were included. The endoscopist visualized the caecum documented by a photo and/or a specimen from terminal ileum. RESULTS: Four hundred and eighty consecutive symptomatic patients [mean age (SD): 42.73 (16.21)] were included. The prevalence of colorectal neoplasia was 15.3% (34 subjects) and 37.7% (181 subjects) had a completely normal colon. Adenomatous polyps were detected in 56 (11.7%) patients, in 12.3% of men and 10.9% of women. The mean age of the patients with a polyp was significantly higher than the others (49.53 ± 14.16 vs 41.85 ± 16.26, P = 0.001). Most of the adenomatous polyps were left sided and tubular; only 22.5% of polyps were more than 10 mm. Cancer was detected in 16 (3.6%) of our study population, which was mostly right sided (57.2%). The mean age of patients with cancer was significantly higher than the others (60.25 ± 8.26 vs 42.13 ± 16.08, P < 0.005) and higher than patients with polyps [60.25 (8.26) vs 49.53 (1.91) (P < 0.0005)]. None of the symptoms (diarrhea, abdominal pain, rectal bleeding, constipation, altering diarrhea and constipation, history of cancer, known irritable bowel disease, history of polyp and fissure or family history of cancer) were predictors for cancer or polyps, but the age of the patient and unexplainedanemia independently predicted cancer. CONCLUSION: Less advanced patterns and smaller sizes of adenomas in Iran is compatible with other data from Asia and the Middle East, but in contrast to western countries. Prevalence of colonic neoplasia in our community seems to be lower than that in western population. Colonic symptoms are not predictors for polyps or cancer but unexplained anemia and elder age can predict CRC. | Yousef Bafandeh Manoochehr Khoshbaten Amir Taher Eftekhar Sadat Sara Farhang | 2008 | World Journal of Gastroenterology2008，14，10： | 2 |
| 4 | Polyunsaturated fatty acids and DNA methylation in colorectal cancer显示文摘Colorectal cancer(CRC) has been designated a major global problem, especially due to its high prevalence in developed countries. CRC mostly occurs sporadically(75%-80%), and only 20%-25% of patients have a family history.Several processes are involved in the development of CRC such as a combination of genetic and epigenetic alterations. Epigenetic changes, including DNA methylation play a vital role in the progression of CRC. Complex interactions between susceptibility genes and environmental factors, such as a diet and sedentary lifestyle, lead to the development of CRC. Clinical and experimental studies have confirmed the beneficial effects of dietary polyunsaturated fatty acids(PUFAs) in preventing CRC. From a mechanistic viewpoint, it has been suggested that PUFAs are pleiotropic agents that alter chromatin remodeling,membrane structure and downstream cell signaling. Moreover, PUFAs can alter the epigenome via modulation of DNA methylation. In this review, we summarize recent investigations linking PUFAs and DNA methylationassociated CRC risk. | Mostafa Moradi Sarabi Reza Mohammadrezaei Khorramabadi Zohre Zare Ebrahim Eftekhar | 2019 | World Journal of Clinical Cases2019，7，24： | 2 |
| 5 | Postoperative sciatic and femoral nerve palsy with reference to leg lengthening and medialization / lateralization of the hip joint following to total hip arthroplasty显示文摘 | Nercessian OA Piccoluga F Eftekhar NS | 1994 | Clin Orthop Relat Res1994，304，7： | 1 |
| 6 | Surgical simulation software for insertion of pedicle screws显示文摘 | Eftekhar B Ghodsi M Ketabchi E | | 0，，： | 1 |
| 7 | Effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles显示文摘 | Eftekhar M Rahmani E Eftekhar T | 2012 | Int J Fertil Steril2012，6，： | 1 |
| 8 | Correlations between crude oil composition and produced water quulity:A multivariate analysis approach显示文摘 | Eftekhar Dadkhah M qye G | 2013 | Ind Eng Chem Res2013，52，17： | 1 |
| 9 | Postpar- tum evaluation of stress urinary incontinence amongprimipa- ras显示文摘 | Eftekhar T Hajibaratali B Ramezanzadeh F | 2006 | Int J GynecolObstet2006，94，2： | 1 |
| 10 | Diagnostic accuracy of dil- atation and curettage for abnormal uterine bleeding显示文摘 | Yarandi F Izadi-Mood N Eftekhar Z | 2010 | J Obstet Gynaecol Res2010，36，5： | 1 |
| 11 | Postpartum evaluation of stress urinary incontinence among primiparas显示文摘 | Eftekhar T Hajibaratali B Ramezanzadeh F | 2006 | Int J Gynaecol Obstet2006，94，2： | 1 |
| 12 | Outcomes and recurrence rates in chronic subdural haematoma显示文摘 | Amirjamshidi A Abouzari M Eftekhar B | 2007 | Br J Neurosurg2007，21，3： | 1 |
| 13 | Indications for the use of temporary arterial occlusion during aneurysm repair:an institutional experience显示文摘 | Eftekhar B Morgan MK | | 0，，： | 1 |
| 14 | Predicting health-related quality of life by using a health promotion model among Iranian adolescent girls:A structural equation modeling approach显示文摘 | Mohamadian H Eftekhar H Rahimi A | 2011 | Nursing&Health Sciences2011，13，2： | 1 |
| 15 | Indications for the use of temporary arterial occlu- sion during aneurysm repair:an institutional experience显示文摘 | Eftekhar B Morgan MK | 2011 | Clin Neurosci2011，18，7： | 1 |
| 16 | Digestion of feed amino acids in the rumen and intestine of steers measured using a mobile nylon bag technique显示文摘 | Taghizadeh A Danesh Mesgaran M Valizadeh R Eftekhar Shahroodi F Stanford K | 2005 | Journal of Dairy Science2005，88，5： | 1 |
| 17 | Experience with low friction arthroplasty:a statistical review of early results and complications显示文摘 | Eftekhar NS Stinchfield FE | 1973 | Clin Orthop1973，95，： | 1 |
| 18 | Comparative study of total hip arthroplasty between younger and older patients显示文摘 | Kobayashu S Eftekhar NS Terayama K | 1997 | Clin Orthop1997，，339： | 1 |
| 19 | Evaluation of clini-cal factors influencing pregnancy rate in frozen embryo trans-fe显示文摘 | Eftekhar M Rahmani E Pourmasumi S | 2014 | Iran J Reprod Med2014，12，7： | 1 |
| 20 | Transfer of blastocysts derived from frozen-thawed cleavage stage embryos improved ongoing pregnancy显示文摘 | Eftekhar M Aflatoonian A Mohammadian F | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员