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| 1 | Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of microribonucleic acids显示文摘5-flurouracil(5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer(CRC).Despite significant progress in the treatment of CRC during the last decades,5-FU drug resistance remains the most important cause of failure in CRC therapy.Resistance to 5-FU is a complex and multistep process.Different mechanisms including microsatellite instability,increased expression level of key enzyme thymidylate synthase and its polymorphism,increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells.Recently,microribonucleic acids(miRNA)and their alterations were found to have a crucial role in 5-FU resistance.In this regard,the miRNA-mediated mechanisms of 5-FU drug resistance reside among the new fields of pharmacogenetics of CRC drug response that has not been completely discovered.Identification of the biological markers that are related to response to 5-FU-based chemotherapy is an emerging field of precision medicine.This approach will have an important role in defining those patients who are most likely to benefit from 5-FU-based chemotherapy in the future.Thereby,the identification of 5-FU drug resistance mechanisms is an essential step to predict and eventually overcome resistance.In the present comprehensive review,we will summarize the latest knowledge regarding the molecular determinants of response to 5-FU-based chemotherapy in CRC by emphasizing the role of miRNAs. | Amirsaeed Sabeti Aghabozorgi Mostafa Moradi Sarabi Reza Jafarzadeh-Esfehani Shabnaz Koochakkhani Marziyeh Hassanzadeh Soudabeh Kavousipour Ebrahim Eftekhar | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 3 |
| 2 | 具核梭杆菌与结直肠癌的研究进展显示文摘结直肠癌(colorectal cancer,CRC)是世界范围内较为高发的恶性肿瘤,近几年,我国的CRC发病率明显升高。大量研究表明微生物在CRC发生发展中发挥重要作用。具核梭杆菌(Fusobacteriumnucleatum,FN)是一种口腔中常见的革兰阴性菌,常累及牙周疾病。但越来越多的研究发现,在CRC组织中,FN的感染率增加,且FN感染与CRC的发生发展有关。因此,本文对FN与CRC的相关研究进展进行综述,以期为CRC的早期诊断、高危人群的识别和治疗提供新的视角。 | 郭术楠 汪庚明 | 2020 | 沈阳医学院学报2020，22，2： | 0 |
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