|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 甲醇/汽油混合燃料发动机非常规排放成分测量方法研究显示文摘对使用气相色谱仪检测甲醇/汽油混合燃料发动机排气中醇醛类排放方法进行了研究,优化选择了采样方法、载气流速、柱温等参数,证明安装PEG色谱柱的GC2010完全可以对甲醇/汽油混合燃料发动机排气中的醇、醛进行精确的检测分析。发动机尾气测试结果表明,汽油机燃用M10混合燃料时,排气中的甲醛中低负荷高达0.2 mg/L。此外,发动机燃用市售汽油和M10两种燃料时,排气中的甲醇、乙醇和乙醛量相差在10%左右,经三效催化转化器后,可以被控制到接近零排放的水平。 | 吕胜春 李晖 Eddy 祁东辉 刘圣华 | 2006 | 内燃机学报2006，24，1： | 32 |
| 2 | Liver natural killer cells: subsets and roles in liver immunity显示文摘肝代表常常由于它的唯一的地点和血供应暴露于许多导出勇气的抗原的一个前线免疫者机关。与在天生的豁免的一个占优势的角色,肝与各种各样的天生的有免疫力的房间,在天赋之中,杀手(NK ) 房间在主人辩护并且在维持有免疫力的平衡起重要作用被充实。肝的 NK 房间首先被描述为 ‘坑 cells’在在 1970 年代的老鼠肝。在老鼠和人的肝的 NK 房间的最近的研究显示出那二个不同 NK 房间子集,肝居民 NK 房间和常规 NK (cNK ) 房间,在这个机关是在场的。这里,我们在不同种类考察肝 NK 细胞子集,重游老鼠与在老鼠和人的肝的居民 NK 细胞有关的肝的坑细胞和加亮的最近的进步,并且也在肝免疫讨论 NK 细胞的双角色。 | Hui Peng Eddie Wisse Zhigang Tian | 2016 | Cellular & Molecular Immunology2016，13，3： | 34 |
| 3 | 乙醇汽油发动机排放特性研究显示文摘在一台JL368Q3多点电喷汽油机上,开展了乙醇汽油(不同掺混比)发动机排放特性的研究,并用GC 2010气相色谱仪测量了排气中未燃醇醛的排放浓度.试验结果表明:在发动机运转参数相同的条件下,燃用E10、E20(乙醇的体积分数分别为10%、20%)混合燃料时,发动机的CO和NOx排放有了较好的改善,降幅可分别达到15%和5%,但在高负荷时发动机的HC排放增加;乙醇汽油发动机排气中的醇醛排放随发动机的转速和负荷增加而增加,其中乙醛排放随燃料中乙醇含量的增加而增加;经过三效催化转化后,乙醇汽油发动机的醇醛在大部分工况下可以实现零排放. | 刘圣华 魏衍举 吕胜春 李晖 Eddy R.Cuty Clemente 祁东辉 | 2006 | 西安交通大学学报2006，40，7： | 25 |
| 4 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 5 | 封闭ERCC1基因表达对卵巢癌细胞耐药的影响显示文摘目的:探讨通过封闭ERCC1基因表达干扰DNA损伤修复路径及其对卵巢癌细胞对铂类药物耐药性的影响。方法:构建ERCC1基因反义表达载体,转染人卵巢癌细胞A2780及A2780/CF70,采用Northern杂交及Western Blot分析人卵巢癌细胞内ERCC1基因RNA及蛋白表达水平变化;利用荧光素酶报告基因系统观察宿主细胞对DNA损伤的修复作用;采用MTT实验研究细胞对铂类药物耐药性的影响。结果:卵巢癌细胞转染反义ERCC1基因后,ERCC1基因转录水平、蛋白表达水平明显下降。荧光素酶报告基因系统结果证明,宿主细胞的DNA修复活性下降。MTT实验表明,伴随ERCC1基因表达水平下降,细胞对顺铂的耐药性降低。结论:转染ERCC1反义基因显著影响宿主细胞的核苷酸切除修复,影响细胞对顺铂的耐药性。 | 李体远 Jing Jie Yu Eddie Reed | 2004 | 中国肿瘤生物治疗杂志2004，11，2： | 14 |
| 6 | 胰腺癌的手术治疗现状显示文摘整块切除是局限性胰腺癌的治疗方法之一。切除相关围手术期病死率低,但在某些高风险患者中其并发症发生率高达50%。随着围手术期治疗护理水平的提高,包括毗邻血管的可获得阴性切缘的根治性切除已在大型医院里实施,早前在胰腺手术中使用微创技术的结果表明其应用前景良好。最新的关于如何降低胰腺相关手术围手术期并发症的数据,在此也将得到讨论。 | Charles B.Kim Shuja Ahmed Eddy C.Hsueh 王卓路(编译) 李新营(编译) | 2013 | 中国普通外科杂志2013，22，9： | 14 |
| 7 | 电喷汽油机燃用醇汽油混合燃料的试验研究显示文摘研究了多点电喷汽油机燃用醇汽油混合燃料的性能。研究结果表明:在汽油机参数未做任何调整的情况下,醇汽油混合燃料发动机的动力性与汽油机相比有所降低,燃料经济性改善,有效热效率提高。随醇类燃料体积分数的增大,CO排放明显改善,THC排放略有升高,NOx排放的变化不明显。醇汽油混合燃料发动机的醛类排放物明显升高,汽油机的未燃甲醇排放较高,未燃乙醇排放变化不明显。 | 祁东辉 刘圣华 李晖 吕胜春 Eddy | 2007 | 内燃机工程2007，28，2： | 13 |
| 8 | 卵巢癌细胞ERCC1基因VIII外显子剪接变异及功能研究显示文摘目的 确认卵巢癌细胞ERCC1基因VIII外显子剪接变异的存在 ,探讨该剪接变异对ERCC1基因表达的作用及其对卵巢癌细胞对铂类药物耐药性的影响。方法 采用Northern杂交及RNA酶保护分析确认人卵巢癌细胞内ERCC1基因调控区在RNA水平存在剪接变异。分别构建野生型及缺失VIII外显子的ERCC1表达载体 ,转染中国仓鼠卵巢 4 3 3B细胞 ,采用Westernblot检测ERCC1表达水平研究该剪接变异对ERCC1基因表达水平的影响 ,采用MTT和细胞克隆形成实验研究该剪接变异细胞对铂类药物耐药性的影响。结果 卵巢癌细胞ERCC1基因VIII外显子存在剪接变异。Westernblot结果显示该剪接变异不显著影响ERCC1表达水平 ,但CHO 4 3 3B细胞MTT及细胞克隆形成实验表明 ,该剪接变异显著影响细胞对顺铂的耐药性。结论 本研究首次证明人卵巢癌细胞、组织ERCC1基因VIII外显子存在剪接变异 ,该变异不显著影响ERCC1基因的绝对表达水平 。 | 李体远 Jing Jie yu Eddie Reed | 2004 | 中国实验诊断学2004，8，4： | 8 |
| 9 | 新型化学反应法制备SiC/Al_2O_3复相陶瓷涂层显示文摘陶瓷涂层材料以其高硬度、耐腐蚀、耐高温、抗氧化等一系列优点,在航空航天、武器装备、核工业、石油化工等领域具有广阔的应用前景。SiC/Al2O3复相陶瓷在常温和高温下都具有较好耐磨性和化学稳定性,是一种极具工程应用前景的复合陶瓷材料。本研究采用优质陶瓷先驱体聚合物PCS,添加惰性填料SiC纳米颗粒和活性填料金属Al粉共同作用,克服了先驱体法制备陶瓷材料中存在较大体积收缩的缺点,在金属基体上制备了单层厚度可达50μm的致密SiC/Al2O3复相陶瓷涂层,复相陶瓷涂层中的SiC来自于先驱体PCS热解转化的SiC和添加的纳米SiC颗粒;其中的Al2O3来自于金属Al粉的氧化。该化学反应方法在金属基体上成功地制备出连续、致密的SiC/Al2O3复相陶瓷涂层,既简单又方便,表现出极大的应用潜力。 | 肖平 杨大祥 赵晓峰 Ian Shapiro Eddie Lopez Honorato 宋永才 | 2009 | 中国表面工程2009，22，6： | 6 |
| 10 | 香港大型体育赛事的发展特征及启示——以体育发展与管理机制分析为背景显示文摘采用文献资料法等,以体育发展与管理机制分析为背景,揭示香港大型体育赛事的发展特征。结果显示:香港以'M'品牌制度及支援计划为基础,强调大型体育赛事的可持续发展;以2008年奥运会马术比赛、2009年东亚运动会为契机,总结赛事实践经验;以赛马为特色,保持与发扬博彩赛事文化。据此提出对大陆体育发展的若干启示。 | Eddie T.C.Lam 范政 | 2015 | 上海体育学院学报2015，39，4： | 6 |
| 11 | Pancreaticoduodenectomy with vascular resection: margin status and survival duration显示文摘 | Jennifer F. Tseng M.D. Chandrajit P. Raut M.D. Jeffrey E. Lee M.D. Peter W. T. Pisters M.D. Jean-Nicolas Vauthey M.D. Eddie K. Abdalla M.D. Henry F. Gomez M.D. Charlotte C. Sun Dr.P.H. Christopher H. Crane M.D. Robert A. Wolff M.D. Douglas B. Evans M.D | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 6 |
| 12 | Intra-operative peritoneal lavage for colorectal cancer显示文摘Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery.Peritoneal lavage in colorectal surgery for cancer is not used in routine,and the prognostic significance of intraperitoneal free cancer cells(IPCC)remains unclear.Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce.However,positive IPCC might be the first step of peritoneal spread in colorectal cancers,which could lead to early specific treatments.Because of the important heterogeneity of IPCC determination in reported studies,no treatment have been proposed to patients why positive IPCC.Herein,we provide an overview of IPCC detection and its impact on recurrence and survival,and we suggest further multi-institutional studies to evaluate new treatment strategies. | Guillaume Passot Kayvan Mohkam Eddy Cotte Olivier Glehen | 2014 | World Journal of Gastroenterology2014，20，8： | 5 |
| 13 | Pattern response of dendritic cells in the tumor microenvironment and breast cancer显示文摘Breast cancer(BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development, including malignancy grade and patient prognosis, is influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological response. Among the immune response cells, dendritic cells(DCs) play a key role in the induction and maintenance of anti-tumor responses owing to their unique abilities for antigen cross-presentation and promotion of the activation of specific lymphocytes that target neoplasic cells. However, the tumor microenvironment can polarize DCs, transforming them into immunosuppressive regulatory DCs, a tolerogenicphenotype which limits the activity of effector T cells and supports tumor growth and progression. Various factors and signaling pathways have been implicated in the immunosuppressive functioning of DCs in cancer, and researchers are working on resolving processes that can circumvent tumor escape and developing viable therapeutic interventions to prevent or reverse the expression of immunosuppressive DCs in the tumor microenvironment. A better understanding of the pattern of DC response in patients with BC is fundamental to the development of specific therapeutic approaches to enable DCs to function properly. Various studies examining DCs immunotherapy have demonstrated its great potential for inducing immune responses to specific antigens and thereby reversing immunosuppression and related to clinical response in patients with BC. DCbased immunotherapy research has led to immense scientific advances, both in our understanding of the antitumor immune response and for the treatment of these patients. | Alessandra da Cunha Marcia A Michelin Eddie FC Murta | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 14 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 15 | Computer analysis of arbitrary reinforced concrete cross-section under bieccentric load | 刁波 叶英华 Siu-Shu Eddie LAM | 2000 | Progress in Natural Science:Materials International2000，10，4： | 5 |
| 16 | Improvement of carbon fiber surface properties using electron beam irradiation显示文摘Carbon fiber-reinforced advance composites have been used for structural applications,mainly on account of their mechanical properties.The main factor for a good mechanical performance of carbon fiber-reinforced com- posite is the interfacial interaction between its components,which are carbon fiber and polymeric matrix.The aim of this study is to improve the surface properties of the carbon fiber using ionizing radiation from an electron beam to obtain better adhesion properties in the resultant composite.EB radiation was applied on the carbon fiber itself before preparing test specimens for the mechanical tests.Experimental results showed that EB irradiation improved the ten- sile strength of carbon fiber samples.The maximum value in tensile strength was reached using doses of about 250 kGy.After breakage,the morphology aspect of the tensile specimens prepared with irradiated and non-irradiated car- bon fibers were evaluated.SEM micrographs showed modifications on the carbon fiber surface. | Eddy Segura PINO Luci Diva Brocardo MACHADO Claudia GIOVEDI | 2007 | Nuclear Science and Techniques2007，18，1： | 5 |
| 17 | Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models显示文摘AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein isothiocyanate(FITC)-dextran was measured to assess permeability across cell monolayers and rat colon tissues. Effects of plecanatide and dolcanatide on the integrity of tight junctions in Caco-2 and T84 monolayers and on the expression and localization of occludin and zonula occludens-1(ZO-1) were examined by immunofluorescence microscopy. Anti-nociceptive activity of these agonists was evaluated in trinitrobenzene sulfonic acid(TNBS)-induced inflammatory as well as in non-inflammatory partial restraint stress(PRS) rat models. Statistical significance between the treatment groups in the permeability studies were evaluated using unpaired t-tests.RESULTS Treatment of T84 and Caco-2 monolayers with lipopolysaccharide(LPS) rapidly increased permeability, which was effectively suppressed when monolayers were also treated with plecanatide or dolcanatide. Similarly, when T84 and Caco-2 monolayers were treated with LPS, cell surface localization of tight junction proteins occludin and ZO-1 was severely disrupted. When cell monolayers were treated with LPS in the presence of plecanatide or dolcanatide, occludin and ZO-1 were localized at the cell surface of adjoining cells, similar to that observed for vehicle treated cells. Treatment of cell monolayers with plecanatide or dolcanatide without LPS did not alter permeability, integrity of tight junctions and cell surface localization of either of the tight junction proteins. In rat visceral hypersensitivity models, both agonists suppressed the TNBS-induced increase in abdominal contractions in response to colorectal distension without affecting the colonic wall elasticity, and both agonists also reduced colonic hypersensitivity in the PRS model. CONCLUSION Our results suggest that activation of GC-C signaling might be involved in maintenance of barrier function, possibly through regulating normal localization of tight junction proteins. Consistent with these findings, plecanatide and dolcanatide showed potent antinociceptive activity in rat visceral hypersensitivity models. These results imply that activation of GC-C signaling may be an attractive therapeutic approach to treat functional constipation disorders and inflammatory gastrointestinal conditions. | Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 18 | Three Hundred and One Consecutive Extended Right Hepatectomies: Evaluation of Outcome Based on Systematic Liver Volumetry显示文摘 | Yoji Kishi Eddie K. Abdalla Yun Shin Chun Daria Zorzi David C. Madoff Michael J. Wallace Steven A. Curley Jean-Nicolas Vauthey | 2009 | Annals of Surgery2009，，4： | 4 |
| 19 | Dynamic responses of two buildings connected by viscoelastic dampers under bidirectional earthquake excitations显示文摘In this study,dynamic responses of two buildings connected by viscoelastic dampers under bidirectional excitations are extensively investigated.The two buildings are a 10-story building and a 16-story building,with the shorter building on the left.Viscoelastic dampers are installed at all fl oors of the shorter building.Equations of motion are formulated using a fractional derivative model to represent the viscoelastic dampers.Three cases are considered with mass eccentricities at 0,10% and-10% with respect to the dimensions of the buildings.The responses of the buildings are numerically predicted at different damper properties.The simulation results indicated that the maximum horizontal responses of the buildings without eccentricities are signifi cantly mitigated.However,torsional effects are adversely increased.For asymmetric buildings,the effectiveness of the connecting dampers is affected by building eccentricities.As a result,mass eccentricities must be taken into account in damper selection.When compared with vibrations induced by unidirectional excitations,bidirectional excitations can increase the responses of coupled asymmetric buildings.In addition,installing dampers only at the top fl oor of the shorter building may cause a sudden change in lateral stiffness of the taller building.Consequently,the story shear envelopes of the taller building are changed. | Z.D. Yang Eddie S.S. Lam | 2014 | Earthquake Engineering and Engineering Vibration2014，13，1： | 4 |
| 20 | 机器人在头颈外科中的应用--香港中文大学经验显示文摘目的:机器人手术目前已在头颈部多个区域得到了应用,本文探讨香港中文大学头颈外科机器人手术的经验。方法:回顾性分析2015年1月以来在香港中文大学耳鼻咽喉头颈外科开展的所有机器人头颈外科手术病例资料。结果:24例患者采用达芬奇S或达芬奇Xi系统进行了手术,21例患者使用新型柔性机器人达芬奇SP系统行了手术。均无二次手术等严重不良事件。已经发表的达芬奇SP系统手术的7例患者早期结果表明,通过达芬奇SP系统可以到达鼻咽、口咽部、下咽部、喉部和咽后淋巴结完成手术,不需中途改变手术方式,没有发生与使用该系统有关的严重不良事件或不良事件。结论:通过我们在香港中文大学的经验,我们认为采用达芬奇机器人系统进行经口手术或经耳后入路颈部手术是安全有效的。 | 陈英权 王维杨 梁发雅 黄晓明 Jason Y K Chan Eddy W Y Wong | 2018 | 临床耳鼻咽喉头颈外科杂志2018，32，14： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员