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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Comparative uterine effects on ovariectomized rats after repeated treatment with different vaginal estrogen formulations显示文摘 | Juan López-Belmonte Concepción Nieto José Estevez Juan L. Delgado Jaime Moscoso del Prado | 2012 | Maturitas2012，，4： | 1 |
| 3 | Lipid nutrition of marine fish during early development:current status and future directions显示文摘 | Sargent J R McEvoy L A Estevez A Bell J G Bell M V Henderson R J Tocher D R | 1999 | Aquaculture1999，179，： | 1 |
| 4 | Lipid nutrition of marine fish during during early development:current status and future directions显示文摘 | Sargent J McEvoy L Estevez A | 1999 | Aquaculture1999，179，： | 1 |
| 5 | Growth, survival, lipid composition and pigmentation of turbot ( Scophtha/mus maximus ) larvae fed live-prey enriched in arachidonic and eicaosapentaenoic acids 显示文摘 | Estevez A McEvoy L A Bell J G | 1999 | Aquaculture1999，180，： | 1 |
| 6 | Isolation and partial characterization of turbot immunoglobulins显示文摘 | Estevez J Leiro J Sanmartin M L | | 0，，： | 1 |
| 7 | Lipid nutrition of marine fish during early development: current status and future directions 显示文摘 | SARGENT J MCEVOY L ESTEVEZ A | 1999 | Aquaculture1999，179，： | 1 |
| 8 | Growth,survival,lipid composiiton and pigmentation of turbot Scophthalmus maximus larvae fed live-prey enriched in arachidonic and eicosapentaenoic acids 显示文摘 | Estevez A McEvoy L A Bell J G et cd | 1999 | Aquaculture1999，180，： | 1 |
| 9 | Weekly docetaxel as neoadjuvant chemotherapy for stage Ⅱ and Ⅲ breast cancer:efficiency and correlation with biological markers in a phase Ⅱ,multicentrestudy显示文摘 | ESTEVEZ L G CUEVAS J M ANTON A | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 10 | Lipid nutrition of marine fish during early development: current status and future directions显示文摘 | Sargent J McEvoy L Estevez A | 1999 | Aquaculture1999，179，14： | 1 |
| 11 | Fiber concentrates from apple pomace and citrus peel as potential fibre sources for food en- richment显示文摘 | FIGUEROLA F HURTADO M L ESTEVEZ A M | 2005 | Food Chem2005，91，： | 1 |
| 12 | Custom cerium oxide nanoparticles protect against a rice radical mediated autoimmune degenerative disease in the brain 显示文摘 | Heckman K L DeCoteau W Estevez A Reed K J Costanzo W Sanford D Leiter J C Clauss J Knapp K Gomez C Mullen P Rathbun E Prime K Marini J Patchefsky J Patchefsky A S Hailstone R K Erli- chman J S | 2013 | ACS Nano2013，7，10： | 1 |
| 13 | Prepara tion and Properties of Biodegradable Starch-clay Nano- composites显示文摘 | CHUNG Y L ANSARI S ESTEVEZ L | 2010 | Carbohydrate Polymers2010，79，2： | 1 |
| 14 | Growth, sur- vival, lipid composition and pigmentation of turbot (Scophthalmus maximus) larvae fed live-prey enriched in Arachidonic and Eicosapentaenoic acids显示文摘 | Estevez A Mcevoy L A Bell J G | 1999 | Aquacul- ture1999，180，34： | 1 |
| 15 | Lipid nutrition of ma- rine fish during early development : current status and future direc- tions显示文摘 | Sargent J R McEvoy L A Estevez A | 1999 | Aquaculture1999，179，14： | 1 |
| 16 | Optimising lipid nutrition in first-feeding flatfish larvae显示文摘 | Bell J G McEvoy L A Estevez A | 2003 | Aquaculture2003，227，14： | 1 |
| 17 | Evaluation of pathologic nipple discharge with ductoscopy 显示文摘 | Hunerbein M Estevez Schwarz L Schneider U | 2003 | J Am Coll Surg2003，197，： | 1 |
| 18 | Increased produc- tion of interleukin 8 in primary human monocytes and in hu- man epithelial and endothelial cell lines after dengue virus chal- lenge显示文摘 | BOSCH I XHAJA K ESTEVEZ L | 2002 | Journal of Virology2002，76，11： | 1 |
| 19 | Modified singular manifold expansion:application to the Boussinesq and Mikhailov-Shabat systems显示文摘 | Estevez P G Gordoa P R Alonso L M | 1993 | J Phys A:Math Gen1993，26，8： | 1 |
| 20 | Non - toxic poly ( ethylene terephthalate)/clay nano- composites with enhanced barrier properties 显示文摘 | HAYRAPETYAN S KELARAKIS A ESTEVEZ L | 2012 | Poly- mer2012，53，2： | 1 |
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