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| 1 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth显示文摘The molecular links between extracellular signals and the regulation of localized protein synthesis in plant cells are poorly understood.Here,we show that in Arabidopsis thaliana,the extracellular peptide RALF1 and its receptor,the FERONIA receptor kinase,promote root hair(RH)tip growth by modulating protein synthesis.We found that RALF1 promotes FERONIA-mediated phosphorylation of elF4E1,a eukaryotic translation initiation factor that plays a crucial role in the control of mRNA translation rate.Phosphorylated elF4E1 increases mRNA affinity and modulates mRNA translation and,thus,protein synthesis.The mRNAs targeted by the RALF1-FERONIA-elF4E1 module include ROP2 and RSL4,which are important regulators of RH cell polarity and growth.RALF1 and FERONIA are expressed in a polar manner in RHs,which facilitate elF4E1 polar丨ocalization and thus may control local f?OP2 translation.Moreover,we demonstrated that high-level accumulation of RSL4 exerts negative-feedback regulation of RALF1 expression by directly binding the RALF1 gene promoter,determining the final RH size.Our study reveals that the link between RALF1-FERONIA signaling and protein synthesis constitutes a novel component regulating cell expansion in these polar growing cells. | Sirui Zhu Jose Manuel Estevez Hongdong Liao Yonghua Zhu Tao Yang Chiyu Li Yichuan Wang Lan Li Xuanming Liu Javier Martinez Pacheco Hongwei Guo Feng Yu | 2020 | Molecular Plant2020，13，5： | 3 |
| 4 | Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi显示文摘Arabidopsis heterotrimeric G 蛋白质控制防卫回答到 necrotrophic 和脉管的真菌。在 G 子单元显示损害的 agb1 异种提高了危险性到这些病原体。G/AGB1 形式一与任何一个一 Arabidopsis G 子单元(1/AGG1 和 2/AGG2 ) 更暗淡的 obligate。因此,我们现在证明 agg1 agg2 加倍异种象到 necrotrophic 真菌 Plectosphaerella cucumerina 的 agb1 植物一样易受影响。阐明 heterotrimeric G-protein-mediated 抵抗的分子的基础,我们与 P 在接种之上执行了 agb1-1 异种和野类型的植物的比较 transcriptomic 分析。cucumerina。和 metabolomic 研究,这分析证明 G-protein-mediated 抵抗独立于为抵抗要求到 necrotrophic 真菌的防御小径,例如发信号的水杨酸酸, jasmonic 酸,乙烯, abscisic 酸,和导出色氨酸的代谢物,当这些小径没在 agb1 和 agg1 agg2 异种被损害。尤其是,在 agb1 植物的许多调整 mis 的基因与房间墙功能被联系,它也是在 agg1 agg2 异种的盒子。生物化学的分析和 Fourier 变换红外线(FTIR ) 从 G 蛋白质异种的房间墙的光谱学比在野类型的植物,和那异种墙有类似的 FTIR spectratypes 的表明木糖内容在 agb1 和 agg1 agg2 异种是更低的,它不同于野类型的植物的。这里介绍的数据在 Arabidopsis 有免疫力的回答和房间墙作文的规定的控制建议 G 和 G1/2 子单元的正规功能。 | Magdalena Delgado-Cerezo Clara Sanchez-Rodriguez Viviana Escudero Eva Miedes Paula Virginia Fernandez Lucia Jorda Camilo Hernandez-Blanco Andrea Sanchez-Vallet Pawel Bednarek Paul Schulze-Lefert Shauna Somervilleg Jose Manuel Estevez Staffan Persson Antonio Molina | 2012 | Molecular Plant2012，5，1： | 3 |
| 5 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 6 | Filling the Gaps to Solve the Extensin Puzzle显示文摘Extensins (EXT ) 是高度重复的植物 O-glycoproteins 要求几 translational 以后修正(PTM ) 在植物房间墙中变得功能。首先,他们是连续脯氨酸残余上的 hydroxylated;然后 ? 他们是 hydroxyproline 上的 O-glycosylated ? 并且丝氨酸。在进 apoplast 的分泌物以后, O-glycosylated EXT 形成 inter-Tyr 和 intra-Tyr 连接组织的一个三度空间的网络。最近的研究在要求处理 EXT 的酶的机械的鉴定取得了重要进步,它包括 prolyl 4-hydroxylases, glycosyltransferases, papain 类型半胱氨酸 endopeptidases,和 peroxidases。EXT 充满植物纸巾 ? 并且在很快扩展根头发和花粉试管是特别地重要的,它以一种极的方式成长。在 EXT PTM 的小面值硬币影响快成长的房间,尽管位于这条规定下面的分子的机制是未知的。在这评论,我们在整个能分泌的小径,在房间墙中的 EXT 集会,和包含 Catharanthus roseus 房间表面传感器的可能的察觉到机制在我们 EXT 修正的理解加亮最近的进展像受体的 kinases ? 在在 apoplast 和血浆膜的细胞质的方面之间的接口定位了。 | Eliana Marzol Cecilia Borassi Mauro Bringas Ana Sede Diana Rosa Rodriguez Garcia Luciana Capece Jose M. Estevez | 2018 | Molecular Plant2018，11，5： | 2 |
| 7 | An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol显示文摘OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments. | Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui Jean-Pierre Armand ZHU Miansheng JU Liya | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 8 | Flexural Strength and Weibull Analysis of Bulk Metallic Glasses显示文摘The flexural strength reliability of bulk metallic glasses(BMGs) plates is analyzed using Weibull statistics.The Weibull modulus(m) and characteristic strength(σ_0) of the Zr_(48)Cu_(45)Al_7 BMG are 34 and 2630 MPa,respectively,which are much higher than the values of fine ceramics(m<30,σ_0< 1600 MPa).In particular,the m values obtained by flexural strength and compressive strength statistics of the Mg_(61)Cu_(28)Gd_(11)BMG are 5 and 33,respectively,indicating that the m values of BMGs are test method dependent,and only the m values obtained by flexural strength statistics can be used to make a convincible comparison with those of ceramics. | Jijun Zhang Diana Estevez Yuan-Yun Zhao Lishan Huo Chuntao Chang Xinmin Wang Run-Wei Li | 2016 | Journal of Materials Science & Technology2016，32，2： | 2 |
| 9 | Influence of increased environmental complexity on leg condition, performance, and level of fearfulness in broilers显示文摘 | Bizeray D I Estevez C Leterrier | 2002 | Poult Sci2002，81，： | 1 |
| 10 | Serum levels of soluble CD30 molecule in Hepatitis B virus infection显示文摘 | Monsalve F Romero-A T Estevez J | 2001 | Rev Med Chil2001，129，11： | 1 |
| 11 | Evaluation of Newcastle disease virus chimeras expressing the Hemagglutinin-Neuraminidase protein of velogenic strains in the context of a mesogenic recombinant virus backbone显示文摘 | Estevez C King D Seal B Yu Q | 2007 | Virus Res2007，129，2： | 1 |
| 12 | Evaluation of Newcas- tle disease virus chimeras expressing the Hemagglutinin-Neu- raminidase protein of velogenic strains in the context of a meso- genic recombinant virus backbone 显示文摘 | Estevez C King D Yu Qing-zhou | 2007 | Virus Res2007，129，： | 1 |
| 13 | Molecular biology of mammalian plasma membrane amino acid transporters 显示文摘 | Palacin M Estevez R Bertran J | 1998 | Physiol Rev1998，78，4： | 1 |
| 14 | M2AP: a minimalist mutual-authentication protocol for low-cost RFIE) tags显示文摘 | Peris-Lopez P Hernandez-Castro J C Estevez Tapiador J M | 2006 | Lecture Notes in Computer Science2006，4159，： | 1 |
| 15 | Cyclic guanosine 5'monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats显示文摘 | Estevez AG Kamaid A Thompson JA | 2002 | Neurosci Lett2002，326，3： | 1 |
| 16 | Normalized mutual information feature selection显示文摘 | ESTEVEZ P A TESMER M PEREZ C A | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，20，2： | 1 |
| 17 | A scalable parallel algorithm for training a hierarchical mixture of neural experts 显示文摘 | Estevez P A Paugam-Moisy H Puzenat D | 2002 | Parallel Computing2002，28，6： | 1 |
| 18 | Effect of PSC 833, verapare iland am iodarone on adriamycin toxicity in cultured rat cardiomyocytes显示文摘 | Estevez MD Wolf A Schramm U | 2000 | Toxicol In Vitro2000，14，1： | 1 |
| 19 | Mo-lecular biology of mammalian plasma membrane ami-no acid transporters显示文摘 | PALACIN M ESTEVEZ R BERTRAN J | 1998 | Physiological Reviews1998，78，4： | 1 |
| 20 | Mitral valve repalaeement in rheumatic patients: effects of chordal preservation 显示文摘 | Garcta-Fuster R Estevez V Gil O | 2008 | Ann Tho- rae Stag2008，86，2： | 1 |
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