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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 3 | Abundance of IFN - alpha and IFN - gamma mRNA in blood of resistant and susceptible chick- ens infected with Marek' s disease virus (MDV)or vaccinated with turkey herpesvirus and MDV inhibition of subsequent induction of IFN gene transcription 显示文摘 | Quere P Rivas C Ester K | 2005 | Arch Virol2005，150，3： | 1 |
| 4 | Density-based cluste- ring in spatial databases: the algorithm GDBSCAN and its applica- tions 显示文摘 | SANDER J ESTER M KRIEGEL H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 5 | Values and Work: Empirical Findings and Theoretical Perspective 显示文摘 | ROE R A ESTER P | 1999 | Applied Psychology :An International Review1999，48，1： | 1 |
| 6 | A density-based algorithm for discovering clusters in large spatial databases with noise 显示文摘 | ESTER M KIEGEL H P | 1996 | International Conference on Knowledge Discovery and Data Mining1996，，2： | 1 |
| 7 | A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid phase extraction显示文摘 | Ester C MRM C P A G | 2004 | Journal of chromatography B2004，813，12： | 1 |
| 8 | Density- based Clustering in Spatial Database: the Algorithm GDBSCAN and Its Applications 显示文摘 | Sander J Ester M Kriegel H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 9 | A Density-Based Algorithm for Discovering Clusters in Large Spatial Databases with Noise显示文摘 | ESTER M KRIEGEL H P SANDER J | 1996 | Kdd1996，96，： | 1 |
| 10 | Spatial data mining: database primitives, algorithms and efficient DBMS support显示文摘 | ESTER M FROMMELT A KRIEGEL H P | 2000 | Data Mining and Knowledge Disoovery2000，4，23： | 1 |
| 11 | Development of a group- specific immtmoassay for sulfonamides application to bee honey analysis 显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，： | 1 |
| 12 | Density based clustering in spatial databases:the algorithm GDBSCAN and its applications显示文摘 | Sander J Ester M Kriegel H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 13 | Values and work:empirical findings and theoretical perspective显示文摘 | Roe R A Ester P | 1999 | Apllied psychology:an international review1999，48，1： | 1 |
| 14 | Knowledge discovery in large SPATIAL database: focusing techniques for etticient class identification 显示文摘 | Ester M Kriegel H P Xu X | 1995 | Advances in Spatial Patabases1995，，： | 1 |
| 15 | Abundance of IFN-alpha and IFN-gamma mRNA in blood of resistant and susceptible chickens infected with Marek' s disease virus(MDV)or vaccinated with turkey herpesvirus;and MDV inhibition of subsequent induction of IFN gene transcription显示文摘 | QUERE P RIVAS C ESTER K | 2005 | Arch Virol2005，150，3： | 1 |
| 16 | Abundance oi IPN-al- pha and 1FN-gamma mRNA in blood of resistant and susceptible chickens infected with Marek's disease vi- rus (MDV) or vaccinated with turkey herpesvirus;and MDV inhibition of subsequent induction of IFN gene transcription显示文摘 | Ouere P Rivas C Ester K | 2005 | Arch Virol2005，150，3： | 1 |
| 17 | Towards an effective cooperation of the user and the computer for classification显示文摘 | Ankerst M Ester M H P K | | 0，，： | 1 |
| 18 | Density-based clustering in spatial databases:The algorithm GDBSCAN and its applications显示文摘 | J Sander M Ester H P Kriegel | 1998 | Data Mining and Knowledgo Discovery1998，2，2： | 1 |
| 19 | Object detection with discriminative- ly trained part-based models 显示文摘 | FELZENSZWALB P F GIRSHICK R B MCALL- ESTER D | 2010 | IEEE Transactions on Knowledge and Data Engineering2010，32，9： | 1 |
| 20 | Density-based clustering in spatial databases:the algorithm GDBSCAN and its applications显示文摘 | Sander J Ester M Kriegel H P | 1998 | Data mining and knowledge discovery1998，2，2： | 1 |
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