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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 3 | Development of an immunomagnetic capture reverse transcription-PCR assay for the detection of Norwalk virus显示文摘 | GILPATRICK S G SCHWAB K J ESTERS M K | 2000 | Journal of Virological Methods2000，90，1： | 1 |
| 4 | Density-based cluste- ring in spatial databases: the algorithm GDBSCAN and its applica- tions 显示文摘 | SANDER J ESTER M KRIEGEL H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 5 | A density-based algorithm for discovering clusters in large spatial databases with noise 显示文摘 | ESTER M KIEGEL H P | 1996 | International Conference on Knowledge Discovery and Data Mining1996，，2： | 1 |
| 6 | Fusarium oxysporum f sp benincasae, a new adaptation of Fusarium oxysporum to cucurbitaceous crop 显示文摘 | GERTAGH M ESTER A | 1985 | Mededelingen van Faculteit Landbou Wetenschappen Rijksuniversiteit Gent1985，50，3： | 1 |
| 7 | Density- based Clustering in Spatial Database: the Algorithm GDBSCAN and Its Applications 显示文摘 | Sander J Ester M Kriegel H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 8 | A Density-Based Algorithm for Discovering Clusters in Large Spatial Databases with Noise显示文摘 | ESTER M KRIEGEL H P SANDER J | 1996 | Kdd1996，96，： | 1 |
| 9 | Algorithms and Efficient DBMS Support显示文摘 | Ester M Frommelt A Kriegel H | 2000 | Data Mining and Knowledge Discovery2000，4，2： | 1 |
| 10 | Spatial data mining: database primitives, algorithms and efficient DBMS support显示文摘 | ESTER M FROMMELT A KRIEGEL H P | 2000 | Data Mining and Knowledge Disoovery2000，4，23： | 1 |
| 11 | Clustering and knowledge discovery in spatial databases显示文摘 | XU X ESTER M KRIEGEL H | 1997 | Vistas in Astronomy1997，41，3： | 1 |
| 12 | Development of a group- specific immtmoassay for sulfonamides application to bee honey analysis 显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，： | 1 |
| 13 | N on-covalent and semi-covalent molecularly imprinted polymers for selective on-line solid-phase extraction of 4 -nitrophenol from water samples 显示文摘 | Ester Caroa Masqu N Marce R M | 2002 | Chromatography A2002，963，12： | 1 |
| 14 | Density based clustering in spatial databases:the algorithm GDBSCAN and its applications显示文摘 | Sander J Ester M Kriegel H P | 1998 | Data Mining and Knowledge Discovery1998，2，2： | 1 |
| 15 | Treatment of IgA nephropathy with ACE inhibitors:A Randomized and Controlled Trial显示文摘 | Praga M Eduardo G Ester G | 2003 | J Am Soc Nephrol2003，14，6： | 1 |
| 16 | Novel enrofloxacin imprinted polymer applied to the solid-phase extraction of fluorinated quinolones from urine and tissue samples显示文摘 | Ester Caro Rosa M Marce | 2006 | Analytica Chimica Acta2006，562，： | 1 |
| 17 | Statistical model-based change detection in moving video 显示文摘 | Aach T Kaup A Ester R M | 1993 | Signal Process- ing1993，31，2： | 1 |
| 18 | Density-based Subspace Clustering in Heterogeneous Networks显示文摘 | Boden B Ester M Seidl T | 2014 | Machine Learning and Knowledge Discovery in Databases2014，8724，： | 1 |
| 19 | Consumer Acceptance of Electron-Beam Irradiated Ready-to-Eat Poultry Meats显示文摘 | JOHNSON ADRIENNE M ESTERS Reynolds A | | 0，，： | 1 |
| 20 | The involvement of cysteine proteases and pretease inhibitor genes in the regulation of programmed cell death in plants显示文摘 | MAZAL S Beatrice B Massimo D Ester M Alex L | | 0，，： | 1 |
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