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| 1 | Effects of interventions on oxidative stress and inflammation of cardiovascular diseases显示文摘Excessive oxidative stress and low-grade chronic inflammation are major pathophysiological factors contributing to the development of cardiovascular diseases (CVD) such as hypertension, diabetes and atherosclerosis. Accumulating evidence suggests that a compromised antioxidant system can lead to excessive oxidative stress in cardiovascular related organs, resulting in cell damage and death. In addition, increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis factor α, interleukin-6 and C-reactive protein, are closely related to morbidity and mortality of cardiovascular complications. Emerging evidence suggests that interventions including nutrition, pharmacology and exercise may activate expression of cellular anti-oxidant systems via the nuclear factor erythroid 2-related factor 2-Kelchlike ECH-associated protein 1 signaling pathway and play a role in preventing inflammatory processes in CVD. The focus of the present review is to summarize recent evidence showing the role of these anti-oxidant and anti-inflammatory interventions in cardiovascular disease. We believe that these findings may prompt new effective pathogenesis-oriented interventions, based on the exercise-induced protection from disease in the cardiovascular system, aimed at targeting oxidant stress and inflammation. | Sewon Lee Yoonjung Park Mozow Yusof Zuidema Mark Hannink | 2011 | World Journal of Cardiology2011，3，1： | 23 |
| 2 | Ischemia/reperfusion injury: The role of immune cells显示文摘Ischemia/reperfusion (I/R) injury is an inflammatory condition that is characterized by innate immunity and an adaptive immune response. This review is focused on the acute inflammatory response in I/R injury, and also the adaptive immunological mechanisms in chronic ischemic disease that lead to increased vulnerability during acute events, in relation to the cell types that have been shown to mediate innate immunity to an adaptive immune response in I/R, specifically myocardial infarction. Novel aspects are also highlighted in respect to the mechanisms within the cardiovascular system and cardiovascular risk factors that may be involved in the inflammatory response accompanying myocardial infarction. Experimental myocardial I/R has suggested that immune cells may mediate reperfusion injury. Specifically, monocytes, macrophages, T-cells, mast cells,platelets and endothelial cells are discussed with reference to the complement cascade, toll-like receptors, cytokines, oxidative stress, renin-angiotensin system, and in reference to the microvascular system in the signaling mechanisms of I/R. Finally, the findings of the data summarized in this review are most important for possible translation into clinical cardiology practice and possible avenues for drug development. | Mozow Y Zuidema | 2010 | World Journal of Cardiology2010，2，10： | 5 |
| 3 | Nasal absorption of alprenolol and metoprolol显示文摘 | Duchateau G Zuidema J | 1986 | Int JPharm1986，34，： | 1 |
| 4 | Different types of s^2 ion luminescence in compounds with eulytite structure显示文摘 | FOLKERTS H F ZUIDEMA J BLASSE G | 1996 | Chemical Physics Letters1996，249，： | 1 |
| 5 | Long term transhepatic intubation for hilar duct strictures显示文摘 | CAMERON J L GAYLER B W ZUIDEMA G D | 1976 | Annals Surgery1976，183，： | 1 |
| 6 | siRNA injection induces sequence-independent protection in Penaeus monodon against white spot syndrome virus显示文摘 | Westenberg M Heinhuis B Zuidema D | 2005 | Virus Research2005，114，12： | 1 |
| 7 | What do we know about rheumatoid arthritis patients' support needs for self-management? A scoping review显示文摘 | Zuidema RM Repping-Wuts H Evers AW | 2015 | Int J Nurs Stud2015，52，10： | 1 |
| 8 | Primary common duct stones显示文摘 | Saharia PC Zuidema GD Cameron JL | 1977 | Ann Surg1977，185，5： | 1 |
| 9 | Clinical aspects of diffuse cutaneous mastocytosis in children:two variants显示文摘 | Heide R Zuidema E Beishuizen A | 2009 | Dermatology2009，219，4： | 1 |
| 10 | The Effect of Aluminum on the Work Hardening and Wear Resistance of Hadfield Manganese Steel显示文摘 | Zuidema B K Subramanyam D K Leslie W C | 1987 | Metallurgical Transactions A1987，18，： | 1 |
| 11 | Factors influencing mortality in the treatment of pyogenic hepatic abscess显示文摘 | Pitt HA Zuidema GD | | Surg Gynecol Obstet0，140，2： | 1 |
| 12 | The clinical significance of retroperitoneal fibrosis显示文摘 | Koep L Zuidema GD | | 0，，03： | 1 |
| 13 | Modified polyurethane foam as a local hemostatic agent after dental extractions 显示文摘 | SELTEN M H BROEKMA F I ZUIDEMA J | 2013 | Ned Tijdschr Tandheelkd2013，120，78： | 1 |
| 14 | Nurse practitioners in the Northern Alberta Renal Program显示文摘 | Nhan J Zuidema S | 2007 | CANNTJ2007，17，2： | 1 |
| 15 | The prerention of upper gastroinstinal tractbleeding in pts in an intensive care unit显示文摘 | Zuidema G D Smith P L | 1981 | Su rg Gynecol Obstet1981，153，： | 1 |
| 16 | Residue analysis of veterinary drugs and growth-promoting agents显示文摘 | Stolker A A M Zuidema T FNielen M W | 2007 | TrAC Trends in Analytical Chemistry2007，26，10： | 1 |
| 17 | siRNA injection induces sequence independent protection in Penaeus monodon against white spot syndrome virus显示文摘 | WESTENBERG M HEINHUIS B ZUIDEMA D | 2005 | Virus Research2005，114，12： | 1 |
| 18 | Playing to win or pla- ying to play显示文摘 | Knoppers A Zuidema M Meyer B | 1989 | Sociology of Sport Journal1989，6，1： | 1 |
| 19 | The clinical significance of retroperitoneal fibrosis显示文摘 | Koep L Zuidema GD | 1977 | Surgery1977，81，： | 1 |
| 20 | Metabolism and depletion of nifursol in broilers 显示文摘 | ZUIDEMA T MULDER P P J RHIJIN J A | 2005 | Analytia Chimica ACTA2005，529，： | 1 |
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