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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Serum Hepcidin;a direct Link between anemia of inflammation and coronary artery atherosclerosis in patients with rheumatoid arthritis显示文摘 | Abdel K M EL-Barbary A M Essa S A | 2011 | J Rheuma- tol2011，38，10： | 1 |
| 3 | Effects of introducing ducks into fish ponds on water quality, natural productivity and fish production together with the economic evaluation of the integrated and non-integrated systems显示文摘 | SOLIMAN A K EL-HORBEETY A A A ESSA M A R | 2000 | Aquaculture International2000，8，： | 1 |
| 4 | Anesthetic implications for video assisted thoracoscopic thymectomy in myasthenia gravis显示文摘 | AL-Kattan K Hajjar W Essa M | 2007 | Middle East Anesthesiol2007，19，1： | 1 |
| 5 | Neuroprotective effect of natural products against alzheimer'sdisease显示文摘 | Essa M M Vijayan R K Castellano-Gonzalez G et O1 | 2012 | Neurochem Res2012，37，9： | 1 |
| 6 | New least-square algorithm for model parameters estimation using self- potential anomalies显示文摘 | Abdelrahman E M Essa K S Abo-Ezz E R | 2008 | Computers & Geosciences2008，34，： | 1 |
| 7 | Shape and depth determinations from second moving average residual self-potential anomalies显示文摘 | Abdelrahman E M El-Araby T M Essa K S | 2009 | Journal of Geophysics and Engineering2009，，6： | 1 |
| 8 | Selective laser melting of A1Si10Mg alloy: process optimization and mechanical properties development显示文摘 | READ N WANG W ESSA K | 2015 | Materials & De- sign2015，，65： | 1 |
| 9 | Neuroprotective effect of natural products against Alzheimer's disease 显示文摘 | ESSA M M VIJAYAN R K CASTELLANO-GONZALEZ G | 2012 | Neurochem Res2012，37，9： | 1 |
| 10 | Diet rich in date palm fruits improves memory,learning and reduces beta amyloid in transgenic mouse model of Alzheimer′s disease显示文摘 | Subash S Essa MM Braidy N Awlad-Thani K Vaishnav R Al-Adawi R | 2015 | J Ayurveda Integr Med2015，6，2： | 1 |
| 11 | Monitoring Agricultural Land Degradation in Egypt Using MODIS NDVI Satellite Images 显示文摘 | Khalil A A Essa Y H Hassanein M K | 2014 | Na- ture & Science2014，12，8： | 1 |
| 12 | Borderline serous cystadenocarcinoma with coexistent angiosarcoma:an unusual form of ovarian carcinosarcoma显示文摘 | Pillay K Essa A S Chetty R | 2001 | Int J Surg Pathol2001，9，4： | 1 |
| 13 | Mathematical model for hermitized atmospheric dispersion in low winds with eddy diffusivities as linear functions of down wind distance 显示文摘 | ESSA K S M ELOTAIFY M S | 2007 | Meteorology and Atmospheric Physics2007，96，34： | 1 |
| 14 | Numerical simulation of sin gle and dual pass conventional spinning processes 显示文摘 | ESSA K HARTLEY P | 2009 | International Journal of Material Forming2009，2，4： | 1 |
| 15 | Full-scaletesting and analysis for blast-resistant d esig n 显示文摘 | M A JI A K BROW N J P U RG ESSA G S | 2008 | Jou rnalof A erospace Engineering2008，21，4： | 1 |
| 16 | Nenroprotective effect of natural products against alzheimer' s disease显示文摘 | Essa M M Vijayan R K Castellano-Gonzalez G | 2012 | Neurochem Res2012，37，9： | 1 |
| 17 | High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence显示文摘BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients. | Essa A Mohamed Nasra H Giama Abubaker O Abdalla Hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts | 2022 | World Journal of Gastroenterology2022，28，35： | 0 |
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