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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 3 | Serum Hepcidin;a direct Link between anemia of inflammation and coronary artery atherosclerosis in patients with rheumatoid arthritis显示文摘 | Abdel K M EL-Barbary A M Essa S A | 2011 | J Rheuma- tol2011，38，10： | 1 |
| 4 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap 显示文摘 | Maeaskie L E Creamer N J Essa A M M Brown N L | 2007 | Biotechnology and Bioengineering2007，96，4： | 1 |
| 5 | Maximal thymectomy in children with myasthenia gravis显示文摘 | Essa M E1 Medany Y Hajjar W | 2003 | Eur J Cardlothorac Surg2003，24，2： | 1 |
| 6 | Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impair- ment,redox balance and Bel-2/Bax expression in experimental Par- kinson' s disease mice 显示文摘 | Kavitha M Nataraj J Essa MM | 2013 | Chem Biol Interact2013，206，2： | 1 |
| 7 | Maximal thymectomy in children with myasthenia gravis显示文摘 | Essa M Medany Y Hajjar W | 2003 | Eur J Cardiothorac Surg2003，24，2： | 1 |
| 8 | Cou- pled eleetrokinetics-adsorption technique for simultane- ous removal of heavy metals and organics from saline- sodic soil 显示文摘 | Lukman S Essa M H Mu'Azu N D Bukhari A | 2013 | The Scientific World Journal2013，2013，34： | 1 |
| 9 | Effects of introducing ducks into fish ponds on water quality, natural productivity and fish production together with the economic evaluation of the integrated and non-integrated systems显示文摘 | SOLIMAN A K EL-HORBEETY A A A ESSA M A R | 2000 | Aquaculture International2000，8，： | 1 |
| 10 | A new approach for the reeovery of preeious metals from solution and from leachates derived from electronic serap显示文摘 | Macaskie L E Creamer N J Essa A M M | | 0，，： | 1 |
| 11 | Predictors of outcome for myasthenia gravis after thymectomy 显示文摘 | El-Medany Y Hajjar W Essa M | 2003 | Asian Cardiovasc Thorac Ann2003，11，4： | 1 |
| 12 | Therapeutic Attenuation of Neuroinflammation and Apoptosis by Black Tea Theaflavin in Chronic MPTP/Probenecid Model of Parkinson's Disease显示文摘 | Anandhan A Essa M M Manivasagam T | 2013 | Ncurotox Res2013，23，2： | 1 |
| 13 | Characterization of rhodamine loaded PEG-PLGA nanoparticles (NPs): effect of poly( ethylene glycol) grafting density 显示文摘 | Essa S Rabanel J M HiIdgen P | 2011 | Int J Pharm2011，411，12： | 1 |
| 14 | A New Approach for the Recovery, of Precious Metals from Solution and fromLeach ates Derived from Electronic Scrap 显示文摘 | Macaskie L E Creamer N J Essa A M M | 2006 | Biotechnology and Bio-engineering2006，96，4： | 1 |
| 15 | Anesthetic implications for video assisted thoracoscopic thymectomy in myasthenia gravis显示文摘 | AL-Kattan K Hajjar W Essa M | 2007 | Middle East Anesthesiol2007，19，1： | 1 |
| 16 | Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells显示文摘 | Muthaiyah B Essa M M Chauhan V et O1 | 2011 | Neurochem Res2011，36，11： | 1 |
| 17 | Characterization of rhodamine loaded PEG-g-PLA nanoparticles (NPs): effect of poly(ethylene glycol) grafting density显示文摘 | Essa S Rabanel J M Hildgen P | | International Journal of Pharmaceutics0，411，12： | 1 |
| 18 | Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice显示文摘 | Kavitha M Nataraj J Essa MM | 2013 | Chem Biol Interact2013，206，2： | 1 |
| 19 | Neuroprotective effect of natural products against alzheimer'sdisease显示文摘 | Essa M M Vijayan R K Castellano-Gonzalez G et O1 | 2012 | Neurochem Res2012，37，9： | 1 |
| 20 | New least-square algorithm for model parameters estimation using self- potential anomalies显示文摘 | Abdelrahman E M Essa K S Abo-Ezz E R | 2008 | Computers & Geosciences2008，34，： | 1 |
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