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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | 乳腺管状小叶癌E-cadherin/cate-nin的表达显示文摘 | Esposito N N Chivukula M Dabbs D J 魏兵(摘译) 步宏(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 8 |
| 3 | 树突状细胞自然杀伤细胞凝集素群受体1促进小鼠动脉粥样硬化的发展显示文摘动脉粥样硬化发展过程中的坏死核心形成与慢性炎症反应有关,其促进斑块发展加快和不稳定。然而,坏死与动脉粥样硬化发展之间的分子生物学联系机制尚未完全清楚。 | 刘莉 叶鹏 Haddad Y Lahoute C Clément M Laurans L Metghalchi S Lynda Z Giraud A Loyer X Vandestienne M Wain-Hobson J Esposito B Potteaux S Ait-Oufella H Tedgui A Mallat Z Taleb S | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Antioxidant activity and dietary fiber in durum wheat bran by-products显示文摘 | ESPOSITO F ARLOTTI G BONIFATI A M | 2005 | Food Research International2005，38，： | 1 |
| 5 | The pharmacology of methotrexate显示文摘 | Barnhart K Coutifaris C Esposito M | 2001 | Expert Opinion on Pharmacotherapy2001，2，3： | 1 |
| 6 | Bioconversion ofapple pomace into a nutritionally enriched substrate by Candida utilis andPleurotus ostreatus显示文摘 | VILLAS-BOAS S G ESPOSITO E MENDONCA M M | 2003 | World Journal of Microbiology&Biotechnology2003，19，： | 1 |
| 7 | Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency显示文摘 | VOS M ESPOSITO G EDIRISINGHE J N | 2012 | Science2012，336，6086： | 1 |
| 8 | Laparoscopic versus open inguinal hernia repair in pediatric patients: a systematic review显示文摘 | Esposito C St Peter SD Escolino M | 2014 | J Laparoendosc Adv Surg Tech A2014，24，11： | 1 |
| 9 | Dextran cross-linked gelatin microspheres as a drug delivery system显示文摘 | Cortesi R Esposito E Osti M | 1999 | European Journal of Pharmaceutical Sciences1999，47，2： | 1 |
| 10 | Left prefrontal activation during episodic remembering:An event-related fMRI study显示文摘 | JOHNSON M K D'ESPOSITO M | 1998 | NeuroReport1998，，9： | 1 |
| 11 | Antioxidant activity and dietary fiber in durum wheat br-an byproducts显示文摘 | Esposito F Arlottib G Bonifati A M | 2005 | Food Research International2005，38，： | 1 |
| 12 | A comparative analysis of methods for pruning decision trees显示文摘 | ESPOSITO M F D SEMERAROG | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，9，5： | 1 |
| 13 | University students' perceptions of the internet: An exploratory study 显示文摘 | D'ESPOSITO J E Gardner R M | 1999 | The Journal of Academic Librarianship1999，25，6： | 1 |
| 14 | A search for type 1 diabetes susceptibility genes in families from the united kingdom显示文摘 | MEIN C A ESPOSITO L DUNN M G | 1998 | Nat Genet1998，19，： | 1 |
| 15 | Weight loss reduces interleukin-18levels in obese women 显示文摘 | Esposito K Pontillo A Ciotola M | 2002 | Clin Ednocrinol Metab2002，87，10： | 1 |
| 16 | Radiological evaluation of marginal bone loss at tooth surfaces facing single Branemark implants 显示文摘 | Esposito M Ekestubbe A Grandahl K | 1993 | Clin Oral Implants Res1993，4，3： | 1 |
| 17 | Effects of frontal lobe damage on interference effects in working memory显示文摘 | Thompson-Schill S.L John J Marshuetz C Smith E.E D'Esposito M Kan I.P | | 0，，02： | 1 |
| 18 | Primary and secondary prevention of atherosclerosis:is there a role for antiox-idants显示文摘 | Paolisso G Esposito R D′Alessio MA Barbieri M | | 0，，04： | 1 |
| 19 | Cosci versus Summers tech- nique for crestal sinus lift:3-year results from a randomised con- trolled trial显示文摘 | Esposito M Cannizzaro G Barausse C | 2014 | Eur J Oral Implantol2014，7，2： | 1 |
| 20 | Treatment of viti- ligo with the 308 nm excimer laser 显示文摘 | Esposito M Soda R Costanzo A | 2004 | Clin Exp Dermatol2004，29，： | 1 |
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