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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Sonic band gaps in finite elastic media:surface states and localiza tion phenomena in linear and point defects显示文摘 | F R Mentero ele Espinosa Garcia-Pablos D | 1999 | Phys Rev Lett1999，82，15： | 1 |
| 3 | Simple but Effective Ferrocene Derivative as aRedox, Colorimetric,and Fluorescent Receptor forHighly Selective Recognition of Zn2+ Ions 显示文摘 | ZAPATA F CABALLERO A ESPINOSA A etal | 2007 | OrgLett2007，，9： | 1 |
| 4 | Immunostimulants for preventing respiratory tract infec- tion in children 显示文摘 | Del-Rio-Navarro BE Espinosa Rosales F Flenady V | 2006 | Cochrane Database Syst Rev2006，18，00： | 1 |
| 5 | Ultrasonic band gap in a periodic two-dimensional composite 显示文摘 | Montero de Espinosa F R | 1998 | Phys Rev Lett1998，80，： | 1 |
| 6 | Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus显示文摘 | Silvarifio R Sant F Espinosa G | 2011 | Lupus2011，20，7： | 1 |
| 7 | Immobilized redox mediators on anion exchange resins and their role on the reductive decolorization of azo dyes显示文摘 | CERVANTES F J GARCIA ESPINOSA A MORENO REY- NOSA M A | 2010 | Environmental Science and Technology2010，44，5： | 1 |
| 8 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nitens ( Deane & Maiden ) Maiden 显示文摘 | Munoz F Rnbilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 9 | Monitoring of heavy metals in topsoils, atmospheric particles and plant leaves to identify possible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microehemical Journal2007，86，： | 1 |
| 10 | Pharmacokinetics of an injectable long-acting parenteral formulation of doxycycline hyclate in pigs显示文摘 | Gutierrez L Ocampo L Espinosa F | 2014 | J Vet Pharmacol Ther2014，37，1： | 1 |
| 11 | Involvement of a Na^+/HCO3^- cotransporter in mouse sperm capacitation显示文摘 | Demarco I A Espinosa F Edwards J | 2007 | Boil Chem2007，278，9： | 1 |
| 12 | Coda wave: a review显示文摘 | HERRAIZ M ESPINOSA A F | 1987 | Pure Appl Geophys1987，125，4： | 1 |
| 13 | A chemical speciation of trace metals for fine urbanparticles 显示文摘 | Espinosa A J F Rodriguez M T De La Rosa F J B | 2002 | Atmospheric Environment2002，36，5： | 1 |
| 14 | Determination of Magnitudes and Relative Signs of1H?19F Coupling Constants through 1D-and 2D-TOCSY Experiments显示文摘 | Espinosa J F | 2013 | Journal of Organic Chemistry2013，78，12： | 1 |
| 15 | Epidemiological and clinical features of hMPV, RSV and RVs infections in young children显示文摘 | Manoha C Espinosa S Aho SL Huet F Pothier P | 2007 | J Clin Virol2007，38，3： | 1 |
| 16 | Characterization of wine yeasts by temperature gradient gel electrophoresis (TGGE) 显示文摘 | Hernan G S Espinosa J C Ubeda J F | 2000 | FEMS Microbiology Letters2000，193，： | 1 |
| 17 | Adaptive UAV Attitude EstimationEmploying Unscented Kalman Filter, FOAM and Low-Cost MEMSSensors显示文摘 | Marina H G Espinosa F Santos C | 2012 | Sensors2012，12，7： | 1 |
| 18 | Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water显示文摘 | Espinosa A C Mazari-Hiriart M Espinosa R MaruriAvidal L Méndez E Arias C F | 2008 | Water Res2008，42，1011： | 1 |
| 19 | An experimental investigation of deformation and fracture of nacre-mother of pearl显示文摘 | BARTHELA T F ESPINOSA H D | 2007 | Experimental Mechanics2007，47，： | 1 |
| 20 | Dual regulation of the T-type Ca^2+ current by serum albumin and β-estradiol in mammalian spermatogenic cens显示文摘 | Espinosa F Lopez-Gonzalez I Munoz-Garay C | 2000 | FEBS Lett2000，475，3： | 1 |
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